The loss of Genome Maintenance Mechanisms (GMM) is one of the most important aspects of human carcinogenesis being related to 90% of the deaths from cancer and several genetic syndromes are known to be associated to GMM disfunction. Ontocancro compiles gene pathways involved in GMM comprising DNA repair mechanisms, cell cycle, apoptosis and senescence. That kind of information is scattered in the scientific literature and in databases. Due to the large heterogeneity of the data from these databases and the absence of a specialized tool in GMM is difficult to build models involving these pathways. Ontocancro aims to facilitate GMM modeling by providing an integrated source of information.
Universidade Federal de Santa Maria, Brazil.