EntrezGene = 1029

ID: 1029
ApprovedSymbol: CDKN2A
EntrezGene: 1029
HGNC: HGNC:1787
UniGeneID: Hs.512599
HugoName: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
UniGeneName: Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
GeneOntologyID: GO:0006309 GO:0006917 GO:0006919 GO:0008637
ENSG: ENSG00000147889
ENSP: ENSP00000355153
KEGGID: hsa+1029
ApprovedSymbol2: CDKN2A
PreviousSymbols: CDKN2, MLM
NCIName: CDKN2A
Evidence: IDA IMP
Chromosome: 9p21
Status: Approved
Reactome_ID:
Aliases: CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a
StringSymbol: CDKN2A
StringName: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] IL10 Anti-inflammatory Signaling Pathway
>>[NCI] G1/S checkpoint
>>[NCI] Extrinsic Pathway for Apoptosis
>>[NCI] NF-kappaB pathway
>>[BioCarta] Cyclins and Cell Cycle Regulation
>>[Reactome] Cell Cycle, Mitotic

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