EntrezGene = 1111

ID: 1111
ApprovedSymbol: CHEK1
EntrezGene: 1111
HGNC: HGNC:1925
UniGeneID: Hs.24529
HugoName: CHK1 checkpoint homolog (S. pombe)
UniGeneName: CHK1 checkpoint homolog (S. pombe)
GeneOntologyID:
ENSG: ENSG00000149554
ENSP: ENSP00000278916
KEGGID: hsa+1111
ApprovedSymbol2: CHEK1
PreviousSymbols:
NCIName: CHEK1
Evidence:
Chromosome: 11q24.2
Status: Approved
Reactome_ID:
Aliases: CHK1
StringSymbol: CHEK1
StringName: CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] ATM signaling
>>[NCI] Extrinsic Pathway for Apoptosis
>>[NCI] Regulation of DNA Replication
>>[NCI] ATR signaling
>>[NCI] NF-kappaB pathway
>>[NCI] p53
>>[Reactome] G1/S DNA Damage Checkpoints
>>[Reactome] Cell Cycle Checkpoints

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