EntrezGene = 11200

ID: 11200
ApprovedSymbol: CHEK2
EntrezGene: 11200
HGNC: HGNC:16627
UniGeneID: Hs.291363
HugoName: CHK2 checkpoint homolog (S. pombe)
UniGeneName: CHK2 checkpoint homolog (S. pombe)
GeneOntologyID: GO:0008630
ENSG: ENSG00000183765
ENSP: ENSP00000372023
KEGGID: hsa+11200
ApprovedSymbol2: CHEK2
PreviousSymbols: RAD53
NCIName: CHEK2
Evidence: IDA
Chromosome: 22q12.1
Status: Approved
Reactome_ID: REACT_1538
Aliases: CDS1, CHK2, HuCds1, PP1425, bA444G7
StringSymbol: CHK2
StringName: CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] ATM signaling
>>[NCI] Extrinsic Pathway for Apoptosis
>>[NCI] NF-kappaB pathway
>>[NCI] p53
>>[Reactome] G1/S DNA Damage Checkpoints
>>[Reactome] Cell Cycle Checkpoints

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