EntrezGene = 1147

ID: 1147
ApprovedSymbol: CHUK
EntrezGene: 1147
HGNC: HGNC:1974
UniGeneID: Hs.198998
HugoName: conserved helix-loop-helix ubiquitous kinase
UniGeneName: Conserved helix-loop-helix ubiquitous kinase
GeneOntologyID:
ENSG: ENSG00000213341
ENSP: ENSP00000359424
KEGGID: hsa+1147
ApprovedSymbol2: CHUK
PreviousSymbols: TCF16
NCIName: CHUK
Evidence:
Chromosome: 10q24-q25
Status: Approved
Reactome_ID: REACT_6900
Aliases: IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA
StringSymbol: -
StringName: conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'S [...]

Related Pathways:

>>[NCI] Canonical NF-kappaB
>>[NCI] Regulation_of_p38-alpha_and_p38-beta
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[Articles] Nemo

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