EntrezGene = 1642

ID: 1642
ApprovedSymbol: DDB1
EntrezGene: 1642
HGNC: HGNC:2717
UniGeneID: Hs.290758
HugoName: damage-specific DNA binding protein 1, 127kDa
UniGeneName: Damage-specific DNA binding protein 1, 127kDa
GeneOntologyID: GO:0000718
ENSG: ENSG00000167986
ENSP: ENSP00000301764
KEGGID: hsa+1642
ApprovedSymbol2: DDB1
PreviousSymbols:
NCIName: DDB1
Evidence: EXP
Chromosome: 11q12-q13
Status: Approved
Reactome_ID:
Aliases: XPE
StringSymbol: DDB1
StringName: damage-specific DNA binding protein 1, 127kDa; Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which [...]

Related Pathways:

>>[Reactome] Mismatch Repair

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