EntrezGene = 1869

ID: 1869
ApprovedSymbol: E2F1
EntrezGene: 1869
HGNC: HGNC:3113
UniGeneID: Hs.654393
HugoName: E2F transcription factor 1
UniGeneName: E2F transcription factor 1
GeneOntologyID:
ENSG: ENSG00000101412
ENSP: ENSP00000345571
KEGGID: hsa+1869
ApprovedSymbol2: E2F1
PreviousSymbols: RBBP3
NCIName: E2F1
Evidence:
Chromosome: 20q11
Status: Approved
Reactome_ID: REACT_152
Aliases: RBP3
StringSymbol: E2F1
StringName: E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis

Related Pathways:

>>[NCI ] G2/M checkpoint
>>[NCI] G1/S checkpoint
>>[NCI] Regulation of DNA Replication
>>[NCI] NF-kappaB pathway
>>[BioCarta] Cyclins and Cell Cycle Regulation
>>[Reactome] Apoptosis - Homo sapiens (human)
>>[Reactome] Mitotic M-M/G1 Phases
>>[Reactome] Cell Cycle, Mitotic
>>[Reactome] Mitotic Spindle Checkpoint

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