EntrezGene = 1965

ID: 1965
ApprovedSymbol: EIF2S1
EntrezGene: 1965
HGNC: HGNC:3265
UniGeneID:
HugoName: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
UniGeneName:
GeneOntologyID:
ENSG: ENSG00000134001
ENSP: ENSP00000256383
KEGGID:
ApprovedSymbol2: EIF2S1
PreviousSymbols: EIF2
NCIName:
Evidence:
Chromosome: 14q21.3
Status: Approved
Reactome_ID:
Aliases: EIF-2alpha, EIF2A
StringSymbol:
StringName: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction [...]

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