EntrezGene = 2068

ID: 2068
ApprovedSymbol: ERCC2
EntrezGene: 2068
HGNC: HGNC:3434
UniGeneID: Hs.487294
HugoName: excision repair cross-complementing rodent repair deficiency, complementation group 2
UniGeneName: Excision repair cross-complementing rodent repair deficiency, complementation group 2
GeneOntologyID: GO:0000717 GO:0000718 GO:0006283 GO:0006917 GO:0033683
ENSG: ENSG00000104884
ENSP: ENSP00000375809
KEGGID: hsa+2068
ApprovedSymbol2: ERCC2
PreviousSymbols: XPD
NCIName: ERCC2
Evidence: EXP IDA IMP
Chromosome: 19q13.3
Status: Approved
Reactome_ID: REACT_1675 REACT_1788 REACT_216 REACT_6185 REACT_71
Aliases: MAG, EM9, MGC102762, MGC126218, MGC126219
StringSymbol: XPD
StringName: excision repair cross-complementing rodent repair deficiency, complementation group 2; ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. Might also have a role in aging process and could play a causative role in the generation of skin cancers

Related Pathways:

>>[Reactome] Mismatch Repair

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