EntrezGene = 3002

ID: 3002
ApprovedSymbol: GZMB
EntrezGene: 3002
HGNC: HGNC:4709
UniGeneID: Hs.1051
HugoName: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
UniGeneName: Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GeneOntologyID: GO:0006922
ENSG: ENSG00000100453
ENSP: ENSP00000216341
KEGGID:
ApprovedSymbol2: GZMB
PreviousSymbols: CTLA1, CSPB
NCIName: GZMB
Evidence: IDA
Chromosome: 14q11.2
Status: Approved
Reactome_ID: REACT_578
Aliases: CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT
StringSymbol: CSPB
StringName: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Related Pathways:

>>[NCI] Apoptotic Execution Phase
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[BioCarta] Granzyme a Mediated Apoptosis Pathway
>>[Reactome] Apoptosis - Homo sapiens (human)

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