EntrezGene = 3014

ID: 3014
ApprovedSymbol: H2AFX
EntrezGene: 3014
HGNC: HGNC:4739
UniGeneID: Hs.477879
HugoName: H2A histone family, member X
UniGeneName: H2A histone family, member X
GeneOntologyID:
ENSG: ENSG00000188486
ENSP: ENSP00000364310
KEGGID:
ApprovedSymbol2: H2AFX
PreviousSymbols: H2AX
NCIName: H2AFX
Evidence:
Chromosome: 11q23.3
Status: Approved
Reactome_ID:
Aliases:
StringSymbol: H2AFX
StringName: H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...]

Related Pathways:

>>[NCI] Double-Strand Break Repair
>>[NCI] Non-Homologous end Joining
>>[NCI] Hr Repair of Replication-Independent DSB
>>[NCI] NF-kappaB pathway

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