EntrezGene = 317

ID: 317
ApprovedSymbol: APAF1
EntrezGene: 317
HGNC: HGNC:576
UniGeneID: Hs.708112
HugoName: apoptotic peptidase activating factor 1
UniGeneName: Apoptotic peptidase activating factor 1
GeneOntologyID: GO:0008635
ENSG: ENSG00000120868
ENSP: ENSP00000353059
KEGGID: hsa+317
ApprovedSymbol2: APAF1
PreviousSymbols:
NCIName: APAF1
Evidence: IDA
Chromosome: 12q23
Status: Approved
Reactome_ID: REACT_578
Aliases: CED4, APAF-1
StringSymbol: CED4
StringName: apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis

Related Pathways:

>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[Reactome] Apoptosis - Homo sapiens (human)

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