EntrezGene = 332

ID: 332
ApprovedSymbol: BIRC5
EntrezGene: 332
UniGeneID: Hs.514527
HugoName: baculoviral IAP repeat-containing 5
UniGeneName: Effector cell peptidase receptor 1 (non-protein coding)
GeneOntologyID: GO:0006916 GO:0043154
ENSG: ENSG00000089685
ENSP: ENSP00000301633
ApprovedSymbol2: BIRC5
PreviousSymbols: API4
Evidence: IDA IMP, IDA
Chromosome: 17q25.3
Status: Approved
Aliases: EPR-1
StringSymbol: API4
StringName: baculoviral IAP repeat-containing 5; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M ph [...]

Related Pathways:

>>[Reactome] Cell Cycle, Mitotic
>>[Reactome] Mitotic Spindle Checkpoint

Quick Links