EntrezGene = 3364

ID: 3364
ApprovedSymbol: HUS1
EntrezGene: 3364
HGNC: HGNC:5309
UniGeneID:
HugoName: HUS1 checkpoint homolog (S. pombe)
UniGeneName:
GeneOntologyID:
ENSG: ENSG00000136273
ENSP: ENSP00000258774
KEGGID:
ApprovedSymbol2: HUS1
PreviousSymbols:
NCIName:
Evidence:
Chromosome: 7p13-p12
Status: Approved
Reactome_ID:
Aliases:
StringSymbol:
StringName: HUS1 checkpoint homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...]

Related Pathways:

>>[NCI] ATR signaling
>>[Reactome] Cell Cycle Checkpoints

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