EntrezGene = 355

ID: 355
ApprovedSymbol: FAS
EntrezGene: 355
HGNC: HGNC:11920
UniGeneID: Hs.244139
HugoName: Fas (TNF receptor superfamily, member 6)
UniGeneName: Fas (TNF receptor superfamily, member 6)
GeneOntologyID: GO:0008624 GO:0008633
ENSG: ENSG00000026103
ENSP: ENSP00000347979
KEGGID: hsa+355
ApprovedSymbol2: FAS
PreviousSymbols: FAS1, APT1, TNFRSF6
Evidence: EXP
Chromosome: 10q24.1
Status: Approved
Reactome_ID: REACT_578
Aliases: CD95, APO-1
StringSymbol: FAS
StringName: Fas (TNF receptor superfamily, member 6); Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

Related Pathways:

>>[NCI] tnfr2 Signaling Pathway
>>[NCI] Regulation of Apoptosis
>>[BioCarta] Apoptotic signaling in response to dna damage

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