EntrezGene = 472

ID: 472
ApprovedSymbol: ATM
EntrezGene: 472
UniGeneID: Hs.367437
HugoName: ataxia telangiectasia mutated
UniGeneName: Ataxia telangiectasia mutated
ENSG: ENSG00000149311
ENSP: ENSP00000278616
KEGGID: hsa+472
ApprovedSymbol2: ATM
PreviousSymbols: ATA, ATDC, ATC, ATD
Chromosome: 11q22-q23
Status: Approved
Aliases: TEL1, TELO1
StringSymbol: ATM
StringName: ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] IL10 Anti-inflammatory Signaling Pathway
>>[NCI] G1/S checkpoint
>>[NCI] ATM signaling
>>[NCI] Base Excision Repair
>>[NCI] Double-Strand Break Repair
>>[NCI] Non-Homologous end Joining
>>[NCI] Extrinsic Pathway for Apoptosis
>>[NCI] Regulation of DNA Replication
>>[NCI] Hr Repair of Replication-Independent DSB
>>[NCI] IL6-mediated signaling events
>>[NCI] NF-kappaB pathway
>>[NCI] Canonical NF-kappaB
>>[NCI] Regulation_of_p38-alpha_and_p38-beta
>>[NCI] p53
>>[NCI] TNF Receptor Signaling Pathway
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[Articles] Nemo
>>[Reactome] G1/S DNA Damage Checkpoints
>>[Reactome] Cell Cycle Checkpoints

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