EntrezGene = 545

ID: 545
ApprovedSymbol: ATR
EntrezGene: 545
HGNC: HGNC:882
UniGeneID: Hs.271791
HugoName: ataxia telangiectasia and Rad3 related
UniGeneName: Ataxia telangiectasia and Rad3 related
GeneOntologyID:
ENSG: ENSG00000175054
ENSP: ENSP00000343741
KEGGID: hsa+545
ApprovedSymbol2: ATR
PreviousSymbols:
NCIName: ATR
Evidence:
Chromosome: 3q22-q24
Status: Approved
Reactome_ID:
Aliases: FRP1, SCKL, SCKL1, MEC1
StringSymbol: ENSG00000175054
StringName: ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] G1/S checkpoint
>>[NCI] ATM signaling
>>[NCI] Base Excision Repair
>>[NCI] Extrinsic Pathway for Apoptosis
>>[NCI] ATR signaling
>>[NCI] NF-kappaB pathway
>>[NCI] p53
>>[Reactome] Cell Cycle Checkpoints

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