EntrezGene = 596

ID: 596
ApprovedSymbol: BCL2
EntrezGene: 596
UniGeneID: Hs.150749
HugoName: B-cell CLL/lymphoma 2
UniGeneName: B-cell CLL/lymphoma 2
GeneOntologyID: GO:0006916 GO:0008633
ENSG: ENSG00000171791
ENSP: ENSP00000329623
KEGGID: hsa+596
ApprovedSymbol2: BCL2
Evidence: EXP IDA
Chromosome: 18q21.3
Status: Approved
Reactome_ID: REACT_578
Aliases: Bcl-2
StringSymbol: BCL2
StringName: B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] NF-kappaB pathway
>>[NCI] p53
>>[NCI] TNF Receptor Signaling Pathway
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[Reactome] Apoptosis - Homo sapiens (human)

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