EntrezGene = 598

ID: 598
ApprovedSymbol: BCL2L1
EntrezGene: 598
HGNC: HGNC:992
UniGeneID: Hs.516966
HugoName: BCL2-like 1
UniGeneName: BCL2-like 1
GeneOntologyID: GO:0001836
ENSG: ENSG00000171552
ENSP: ENSP00000302564
KEGGID: hsa+598
ApprovedSymbol2: BCL2L1
PreviousSymbols:
NCIName: BCL2L1
Evidence: IDA
Chromosome: 20q11.21
Status: Approved
Reactome_ID: REACT_578
Aliases: BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS
StringSymbol: BCL2L1
StringName: BCL2-like 1; Potent inhibitor of cell death. Isoform Bcl-X(L) anti- apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis

Related Pathways:

>>[NCI] mtor signaling
>>[NCI] TNF Receptor Signaling Pathway
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[Reactome] Apoptosis - Homo sapiens (human)

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