EntrezGene = 63967

ID: 63967
ApprovedSymbol: CLSPN
EntrezGene: 63967
HGNC: HGNC:19715
UniGeneID:
HugoName: claspin
UniGeneName:
GeneOntologyID:
ENSG: ENSG00000092853
ENSP: ENSP00000312995
KEGGID:
ApprovedSymbol2: CLSPN
PreviousSymbols:
NCIName:
Evidence:
Chromosome: 1p34.3
Status: Approved
Reactome_ID:
Aliases:
StringSymbol:
StringName: claspin homolog (Xenopus laevis); Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks

Related Pathways:

>>[NCI] Intrinsic Pathway for Apoptosis
>>[NCI] ATR signaling
>>[NCI] NF-kappaB pathway
>>[Reactome] Cell Cycle Checkpoints

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