EntrezGene = 701

ID: 701
ApprovedSymbol: BUB1B
EntrezGene: 701
UniGeneID: Hs.631699
HugoName: budding uninhibited by benzimidazoles 1 homolog beta (yeast)
UniGeneName: BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)
ENSG: ENSG00000156970
ENSP: ENSP00000287598
KEGGID: hsa+701
ApprovedSymbol2: BUB1B
Chromosome: 15q15
Status: Approved
Aliases: BUBR1, MAD3L, Bub1A, SSK1
StringSymbol: BUB1B
StringName: budding uninhibited by benzimidazoles 1 homolog beta (yeast); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Negatively regulates PLK1 activity in interphase cel [...]

Related Pathways:

>>[BioCarta] Rb Tumor suppressor/Check. P. Sign. in Response to Damage
>>[Reactome] Regulation of Mitotic Cell Cycle
>>[Reactome] Cell Cycle, Mitotic
>>[Reactome] Mitotic Spindle Checkpoint
>>[Reactome] Cell Cycle Checkpoints

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