EntrezGene = 834

ID: 834
ApprovedSymbol: CASP1
EntrezGene: 834
HGNC: HGNC:1499
UniGeneID: Hs.2490
HugoName: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
UniGeneName: Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
GeneOntologyID:
ENSG: ENSG00000137752
ENSP: ENSP00000410076
KEGGID:
ApprovedSymbol2: CASP1
PreviousSymbols: IL1BC
NCIName: CASP1
Evidence:
Chromosome: 11q23
Status: Approved
Reactome_ID:
Aliases: ICE
StringSymbol: CASP1
StringName: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. A [...]

Related Pathways:

>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors

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