EntrezGene = 836

ID: 836
ApprovedSymbol: CASP3
EntrezGene: 836
HGNC: HGNC:1504
UniGeneID: Hs.141125
HugoName: caspase 3, apoptosis-related cysteine peptidase
UniGeneName: Caspase 3, apoptosis-related cysteine peptidase
GeneOntologyID: GO:0030264 GO:0043066
ENSG: ENSG00000164305
ENSP: ENSP00000311032
KEGGID: hsa+836
ApprovedSymbol2: CASP3
PreviousSymbols:
NCIName: CASP3
Evidence: IGI IMP
Chromosome: 4q34
Status: Approved
Reactome_ID: REACT_578
Aliases: CPP32, CPP32B, Yama, apopain
StringSymbol: CASP3
StringName: caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

Related Pathways:

>>[NCI] Death Receptor Signalling
>>[NCI] Intrinsic Pathway for Apoptosis
>>[NCI] Apoptotic Execution Phase
>>[NCI] Caspase Cascade in Apoptosis
>>[NCI] TNF Receptor Signaling Pathway
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[Reactome] Apoptosis - Homo sapiens (human)

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