EntrezGene = 841

ID: 841
ApprovedSymbol: CASP8
EntrezGene: 841
HGNC: HGNC:1509
UniGeneID: Hs.599762
HugoName: caspase 8, apoptosis-related cysteine peptidase
UniGeneName: Caspase 8, apoptosis-related cysteine peptidase
GeneOntologyID: GO:0008624 GO:0008633
ENSG: ENSG00000064012
ENSP: ENSP00000351273
KEGGID: hsa+841
ApprovedSymbol2: CASP8
PreviousSymbols:
NCIName: CASP8
Evidence: EXP
Chromosome: 2q33-q34
Status: Approved
Reactome_ID: REACT_578
Aliases: MCH5, MACH, FLICE, Casp-8
StringSymbol: MCH5
StringName: caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]

Related Pathways:

>>[Ontocancro] TGF
>>[NCI] tnfr2 Signaling Pathway
>>[NCI] Death Receptor Signalling
>>[NCI] Intrinsic Pathway for Apoptosis
>>[NCI] Regulation of Apoptosis
>>[NCI] p53
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[BioCarta] tnfr1 Signaling Pathway
>>[Reactome] Apoptosis - Homo sapiens (human)

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