EntrezGene = 842

ID: 842
ApprovedSymbol: CASP9
EntrezGene: 842
HGNC: HGNC:1511
UniGeneID: Hs.329502
HugoName: caspase 9, apoptosis-related cysteine peptidase
UniGeneName: Caspase 9, apoptosis-related cysteine peptidase
GeneOntologyID:
ENSG: ENSG00000132906
ENSP: ENSP00000330237
KEGGID: hsa+842
ApprovedSymbol2: CASP9
PreviousSymbols:
NCIName: CASP9
Evidence:
Chromosome: 1p36.21
Status: Approved
Reactome_ID: REACT_578
Aliases: MCH6, ICE-LAP6, APAF-3
StringSymbol: CASP9
StringName: caspase 9, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)

Related Pathways:

>>[NCI] Caspase Cascade in Apoptosis
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors
>>[Reactome] Apoptosis - Homo sapiens (human)

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