EntrezGene = 843

ID: 843
ApprovedSymbol: CASP10
EntrezGene: 843
HGNC: HGNC:1500
UniGeneID: Hs.5353
HugoName: caspase 10, apoptosis-related cysteine peptidase
UniGeneName: Caspase 10, apoptosis-related cysteine peptidase
GeneOntologyID: GO:0008624
ENSG: ENSG00000003400
ENSP: ENSP00000286186
KEGGID: hsa+843
ApprovedSymbol2: CASP10
PreviousSymbols:
NCIName: CASP10
Evidence: EXP
Chromosome: 2q33-q34
Status: Approved
Reactome_ID: REACT_578
Aliases: MCH4
StringSymbol: CASP10
StringName: caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC

Related Pathways:

>>[NCI] tnfr2 Signaling Pathway
>>[NCI] Death Receptor Signalling
>>[NCI] Regulation of Apoptosis
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] Induction of apoptosis through dr3 and dr4/5 death receptors

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