EntrezGene = 8450

ID: 8450
ApprovedSymbol: CUL4B
EntrezGene: 8450
HGNC: HGNC:2555
UniGeneID: Hs.102914
HugoName: cullin 4B
UniGeneName: Cullin 4B
GeneOntologyID:
ENSG: ENSG00000158290
ENSP: ENSP00000384109
KEGGID: hsa+8450
ApprovedSymbol2: CUL4B
PreviousSymbols:
NCIName: CUL4B
Evidence:
Chromosome: Xq23
Status: Approved
Reactome_ID:
Aliases:
StringSymbol: CUL4B
StringName: cullin 4B; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. DC4BX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 in response to radiation-induced DNA damage and during DNA replication. Required for hi [...]

Related Pathways:

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