EntrezGene = 8451

ID: 8451
ApprovedSymbol: CUL4A
EntrezGene: 8451
HGNC: HGNC:2554
UniGeneID: Hs.339735
HugoName: cullin 4A
UniGeneName: Cullin 4A
GeneOntologyID:
ENSG: ENSG00000139842
ENSP: ENSP00000364589
KEGGID: hsa+8451
ApprovedSymbol2: CUL4A
PreviousSymbols:
NCIName: CUL4A
Evidence:
Chromosome: 13q34
Status: Approved
Reactome_ID:
Aliases:
StringSymbol: CUL4A
StringName: cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...]

Related Pathways:

>>[Reactome] Mismatch Repair

Quick Links