EntrezGene = 8454

ID: 8454
ApprovedSymbol: CUL1
EntrezGene: 8454
HGNC: HGNC:2551
UniGeneID: Hs.146806
HugoName: cullin 1
UniGeneName: Cullin 1
GeneOntologyID:
ENSG: ENSG00000055130
ENSP: ENSP00000326804
KEGGID: hsa+8454
ApprovedSymbol2: CUL1
PreviousSymbols:
NCIName: CUL1
Evidence:
Chromosome: 7q36.1
Status: Approved
Reactome_ID:
Aliases:
StringSymbol: CUL1
StringName: cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associ [...]

Related Pathways:

>>[Reactome] Regulation of Mitotic Cell Cycle
>>[Reactome] S Phase
>>[Reactome] Cell Cycle, Mitotic

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