EntrezGene = 8772

ID: 8772
ApprovedSymbol: FADD
EntrezGene: 8772
UniGeneID: Hs.86131
HugoName: Fas (TNFRSF6)-associated via death domain
UniGeneName: Fas (TNFRSF6)-associated via death domain
GeneOntologyID: GO:0008633
ENSG: ENSG00000168040
ENSP: ENSP00000301838
KEGGID: hsa+8772
ApprovedSymbol2: FADD
Evidence: EXP
Chromosome: 11q13.3
Status: Approved
Reactome_ID: REACT_578
Aliases: MORT1, GIG3
StringSymbol: FADD
StringName: Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis

Related Pathways:

>>[NCI] tnfr2 Signaling Pathway
>>[NCI] Regulation of Apoptosis
>>[BioCarta] Apoptotic signaling in response to dna damage
>>[BioCarta] tnfr1 Signaling Pathway

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