EntrezGene = 8837

ID: 8837
ApprovedSymbol: CFLAR
EntrezGene: 8837
HGNC: HGNC:1876
UniGeneID: Hs.390736
HugoName: CASP8 and FADD-like apoptosis regulator
UniGeneName: CASP8 and FADD-like apoptosis regulator
GeneOntologyID:
ENSG: ENSG00000003402
ENSP: ENSP00000312455
KEGGID: hsa+8837
ApprovedSymbol2: CFLAR
PreviousSymbols: CASP8AP1
NCIName: CFLAR
Evidence:
Chromosome: 2q33-q34
Status: Approved
Reactome_ID:
Aliases: CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT
StringSymbol: CFLAR
StringName: CASP8 and FADD-like apoptosis regulator; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Related Pathways:

>>[NCI] tnfr2 Signaling Pathway
>>[NCI] Regulation of Apoptosis
>>[BioCarta] Apoptotic signaling in response to dna damage

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