EntrezGene = 902

ID: 902
ApprovedSymbol: CCNH
EntrezGene: 902
UniGeneID: Hs.292524
HugoName: cyclin H
UniGeneName: Cyclin H
GeneOntologyID: GO:0000718
ENSG: ENSG00000134480
ENSP: ENSP00000256897
KEGGID: hsa+902
ApprovedSymbol2: CCNH
Evidence: EXP
Chromosome: 5q13.3-q14
Status: Approved
Aliases: CAK, p34, p37
StringSymbol: CCNH
StringName: cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throug [...]

Related Pathways:

>>[Reactome] Mitotic M-M/G1 Phases
>>[Reactome] Mismatch Repair
>>[Reactome] S Phase
>>[Reactome] Cell Cycle, Mitotic

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