EntrezGene = 9156

ID: 9156
ApprovedSymbol: EXO1
EntrezGene: 9156
UniGeneID: Hs.498248
HugoName: exonuclease 1
UniGeneName: Exonuclease 1
GeneOntologyID: GO:0006298
ENSG: ENSG00000174371
ENSP: ENSP00000311873
KEGGID: hsa+9156
ApprovedSymbol2: EXO1
Evidence: IDA IMP IPI
Chromosome: 1q42-q43
Status: Approved
Aliases: HEX1, hExoI
StringSymbol: EXO1
StringName: exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. E [...]

Related Pathways:

>>[NCI] Homologous Recombination

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