NAME: Cell Cycle Checkpoints

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
64682 ANAPC1 64682 HGNC:19988 Hs.436527 218575_at
229267_at
231973_s_at
anaphase promoting complex subunit 1 Anaphase promoting complex subunit 1 ENSG00000153107 ENSP00000339109 hsa+64682 ANAPC1 ANAPC1 2q12.1 Approved MCPR, TSG24, APC1 ANAPC1 anaphase promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
10393 ANAPC10 10393 HGNC:24077 Hs.480876 207845_s_at
241959_at
anaphase promoting complex subunit 10 Anaphase promoting complex subunit 10 ENSG00000164162 ENSP00000310071 hsa+10393 ANAPC10 ANAPC10 4q31 Approved APC10, DOC1, DKFZP564L0562 APC10 anaphase promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51529 ANAPC11 51529 HGNC:14452 Hs.534456 224010_at
226414_s_at
anaphase promoting complex subunit 11 APC11 anaphase promoting complex subunit 11 ENSG00000141552 ENSP00000349957 hsa+51529 ANAPC11 ANAPC11 17q25.3 Approved HSPC214, APC11, Apc11p, MGC882 APC11 anaphase promoting complex subunit 11; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex
29882 ANAPC2 29882 HGNC:19989 Hs.533262 218555_at
anaphase promoting complex subunit 2 Anaphase promoting complex subunit 2 ENSG00000176248 ENSP00000314004 hsa+29882 ANAPC2 ANAPC2 9q34.3 Approved APC2, KIAA1406 ANAPC2 anaphase promoting complex subunit 2; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
29945 ANAPC4 29945 HGNC:19990 Hs.152173 226917_s_at
232524_x_at
anaphase promoting complex subunit 4 Anaphase promoting complex subunit 4 ENSG00000053900 ENSP00000318775 hsa+29945 ANAPC4 ANAPC4 4p15.31 Approved APC4 ANAPC4 anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51433 ANAPC5 51433 HGNC:15713 Hs.7101 200098_s_at
208721_s_at
208722_s_at
211036_x_at
239651_at
anaphase promoting complex subunit 5 Anaphase promoting complex subunit 5 ENSG00000089053 ENSP00000261819 hsa+51433 ANAPC5 ANAPC5 12q24 Approved APC5 APC5 anaphase promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51434 ANAPC7 51434 HGNC:17380 Hs.529280 225521_at
225554_s_at
anaphase promoting complex subunit 7 Anaphase promoting complex subunit 7 ENSG00000196510 ENSP00000394394 hsa+51434 ANAPC7 ANAPC7 12q13.12 Approved APC7 ANAPC7 anaphase promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
84126 ATRIP 84126 HGNC:33499 1552937_s_at
ATR interacting protein ENSG00000164053 ENSP00000323099 ATRIP 3p24.3-p22.1 Approved FLJ12343, MGC20625, MGC21482, MGC26740 ATR interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein
701 BUB1B 701 HGNC:1149 Hs.631699 203755_at
budding uninhibited by benzimidazoles 1 homolog beta (yeast) BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) ENSG00000156970 ENSP00000287598 hsa+701 BUB1B BUB1B 15q15 Approved BUBR1, MAD3L, Bub1A, SSK1 BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Negatively regulates PLK1 activity in interphase cel [...]
9184 BUB3 9184 HGNC:1151 Hs.418533 201456_s_at
201457_x_at
201458_s_at
209974_s_at
229827_at
budding uninhibited by benzimidazoles 3 homolog (yeast) BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) ENSG00000154473 ENSP00000357858 hsa+9184 BUB3 BUB3 10q24 Approved BUB3L BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast); Required for kinetochore localization of BUB1
891 CCNB1 891 HGNC:1579 Hs.23960 214710_s_at
228729_at
cyclin B1 Cyclin B1 ENSG00000134057 ENSP00000256442 hsa+891 CCNB1 CCNB CCNB1 5q12 Approved CCNB1 cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition
9133 CCNB2 9133 HGNC:1580 Hs.194698 1560161_at
202705_at
232764_at
232768_at
cyclin B2 Cyclin B2 ENSG00000157456 ENSP00000288207 hsa+9133 CCNB2 CCNB2 15q21.3 Approved HsT17299 CCNB2 cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition
898 CCNE1 898 HGNC:1589 Hs.244723 213523_at
242105_at
cyclin E1 Cyclin E1 ENSG00000105173 ENSP00000262643 hsa+898 CCNE1 CCNE CCNE1 19q12 Approved CCNE cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition
9134 CCNE2 9134 HGNC:1590 Hs.567387 205034_at
211814_s_at
cyclin E2 Cyclin E2 ENSG00000175305 ENSP00000309181 hsa+9134 CCNE2 CCNE2 8q22.1 Approved CYCE2 CCNE2 cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase
8881 CDC16 8881 HGNC:1720 Hs.374127 202717_s_at
209658_at
209659_s_at
cell division cycle 16 homolog (S. cerevisiae) Cell division cycle 16 homolog (S. cerevisiae) ENSG00000130177 ENSP00000348554 hsa+8881 CDC16 CDC16 13q34 Approved APC6 CDC16 cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
983 CDC2 983 HGNC:1722 Hs.334562 203213_at
203214_x_at
210559_s_at
231534_at
cell division cycle 2, G1 to S and G2 to M Cell division cycle 2, G1 to S and G2 to M GO:0006916 ENSG00000170312 ENSP00000362917 hsa+983 CDC2 CDC2 IDA 10q21.2 Approved REACT_152 REACT_1538 REACT_6850 CDC28A ENSG00000170312 cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
991 CDC20 991 HGNC:1723 Hs.524947 202870_s_at
cell division cycle 20 homolog (S. cerevisiae) Cell division cycle 20 homolog (S. cerevisiae) ENSG00000117399 ENSP00000308450 hsa+991 CDC20 CDC20 1p34.1 Approved p55CDC, CDC20A CDC20 cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates
8697 CDC23 8697 HGNC:1724 Hs.153546 202892_at
223651_x_at
cell division cycle 23 homolog (S. cerevisiae) Cell division cycle 23 homolog (S. cerevisiae) ENSG00000094880 ENSP00000378350 hsa+8697 CDC23 CDC23 5q31 Approved APC8 APC8 cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
995 CDC25C 995 HGNC:1727 Hs.656 205167_s_at
216914_at
217010_s_at
cell division cycle 25 homolog C (S. pombe) Cell division cycle 25 homolog C (S. pombe) ENSG00000158402 ENSP00000321656 hsa+995 CDC25C CDC25 CDC25C 5q31 Approved CDC25C cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity
246184 CDC26 246184 HGNC:17839 Hs.530284 225422_at
cell division cycle 26 homolog (S. cerevisiae) Cell division cycle 26 homolog (S. cerevisiae) ENSG00000176386 ENSP00000363322 hsa+246184 CDC26 C9orf17 CDC26 9q32 Approved CDC26 cell division cycle 26 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex
996 CDC27 996 HGNC:1728 Hs.463295 217878_s_at
217879_at
217880_at
217881_s_at
cell division cycle 27 homolog (S. cerevisiae) Cell division cycle 27 homolog (S. cerevisiae) ENSG00000004897 ENSP00000399255 hsa+996 CDC27 D0S1430E, D17S978E CDC27 17q21.32 Approved APC3 APC3 cell division cycle 27 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
8318 CDC45L 8318 HGNC:1739 Hs.474217 204126_s_at
CDC45 cell division cycle 45-like (S. cerevisiae) CDC45 cell division cycle 45-like (S. cerevisiae) ENSG00000093009 ENSP00000263201 hsa+8318 CDC45L CDC45L2 CDC45L 22q11.21 Approved CDC45L CDC45 cell division cycle 45-like (S. cerevisiae); Required for initiation of chromosomal DNA replication
990 CDC6 990 HGNC:1744 Hs.405958 203967_at
203968_s_at
cell division cycle 6 homolog (S. cerevisiae) Cell division cycle 6 homolog (S. cerevisiae) ENSG00000094804 ENSP00000209728 hsa+990 CDC6 CDC18L CDC6 17q21.3 Approved CDC6 cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
8317 CDC7 8317 HGNC:1745 Hs.533573 204510_at
cell division cycle 7 homolog (S. cerevisiae) Cell division cycle 7 homolog (S. cerevisiae) ENSG00000097046 ENSP00000234626 hsa+8317 CDC7 CDC7L1 CDC7 1p22 Approved Hsk1, huCdc7, HsCdc7 CDC7 cell division cycle 7 homolog (S. cerevisiae); Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1027 CDKN1B 1027 HGNC:1785 Hs.238990 209112_at
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cyclin-dependent kinase inhibitor 1B (p27, Kip1) GO:0006917 ENSG00000111276 ENSP00000228872 hsa+1027 CDKN1B CDKN1B IDA 12p13.1-p12 Approved KIP1, P27KIP1 KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
205394_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
11200 CHEK2 11200 HGNC:16627 Hs.291363 210416_s_at
CHK2 checkpoint homolog (S. pombe) CHK2 checkpoint homolog (S. pombe) GO:0008630 ENSG00000183765 ENSP00000372023 hsa+11200 CHEK2 RAD53 CHEK2 IDA 22q12.1 Approved REACT_1538 CDS1, CHK2, HuCds1, PP1425, bA444G7 CHK2 CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'
63967 CLSPN 63967 HGNC:19715 1553120_at
219621_at
242150_at
243840_at
claspin ENSG00000092853 ENSP00000312995 CLSPN 1p34.3 Approved claspin homolog (Xenopus laevis); Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks
10926 DBF4 10926 HGNC:17364 Hs.485380 204244_s_at
DBF4 homolog (S. cerevisiae) DBF4 homolog (S. cerevisiae) ENSG00000006634 ENSP00000265728 hsa+10926 DBF4 DBF4 7q21.3 Approved ASK, DBF4A, chif, ZDBF1 DBF4 DBF4 homolog (S. cerevisiae); Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle
3364 HUS1 3364 HGNC:5309 204883_s_at
204884_s_at
217618_x_at
HUS1 checkpoint homolog (S. pombe) ENSG00000136273 ENSP00000258774 HUS1 7p13-p12 Approved HUS1 checkpoint homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...]
8379 MAD1L1 8379 HGNC:6762 Hs.654838 204857_at
MAD1 mitotic arrest deficient-like 1 (yeast) MAD1 mitotic arrest deficient-like 1 (yeast) ENSG00000002822 ENSP00000382562 hsa+8379 MAD1L1 MAD1L1 7p22 Approved HsMAD1, TXBP181, MAD1, PIG9, TP53I9 MAD1 MAD1 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery
4085 MAD2L1 4085 HGNC:6763 Hs.591697 1554768_a_at
203362_s_at
MAD2 mitotic arrest deficient-like 1 (yeast) MAD2 mitotic arrest deficient-like 1 (yeast) ENSG00000164109 ENSP00000296509 hsa+4085 MAD2L1 MAD2L1 4q27 Approved MAD2, HSMAD2 MAD2 MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate
55388 MCM10 55388 HGNC:18043 Hs.198363 220651_s_at
222962_s_at
223570_at
minichromosome maintenance complex component 10 Minichromosome maintenance complex component 10 ENSG00000065328 ENSP00000354945 MCM10 MCM10 10p13 Approved PRO2249, CNA43, DNA43 MCM10 minichromosome maintenance complex component 10; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication
4171 MCM2 4171 HGNC:6944 Hs.477481 202107_s_at
minichromosome maintenance complex component 2 Minichromosome maintenance complex component 2 ENSG00000073111 ENSP00000265056 hsa+4171 MCM2 CCNL1, CDCL1 MCM2 3q21 Approved D3S3194, KIAA0030, BM28, cdc19 BM28 minichromosome maintenance complex component 2; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division
4172 MCM3 4172 HGNC:6945 Hs.179565 201555_at
minichromosome maintenance complex component 3 Minichromosome maintenance complex component 3 ENSG00000112118 ENSP00000229854 hsa+4172 MCM3 MCM3 6p12 Approved MCM3 minichromosome maintenance complex component 3; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation
4173 MCM4 4173 HGNC:6947 Hs.460184 212141_at
212142_at
222036_s_at
222037_at
minichromosome maintenance complex component 4 Minichromosome maintenance complex component 4 ENSG00000104738 ENSP00000262105 hsa+4173 MCM4 CDC21 MCM4 8q12-q13 Approved CDC54, hCdc21, P1-Cdc21, MGC33310 MCM4 minichromosome maintenance complex component 4; Involved in the control of DNA replication
4174 MCM5 4174 HGNC:6948 Hs.517582 201755_at
216237_s_at
minichromosome maintenance complex component 5 Minichromosome maintenance complex component 5 ENSG00000100297 ENSP00000216122 hsa+4174 MCM5 CDC46 MCM5 22q13.1-q13.2 Approved MCM5 minichromosome maintenance complex component 5
4175 MCM6 4175 HGNC:6949 Hs.444118 201930_at
238977_at
minichromosome maintenance complex component 6 Minichromosome maintenance complex component 6 ENSG00000076003 ENSP00000264156 hsa+4175 MCM6 MCM6 2q14-q21 Approved Mis5 MCM6 minichromosome maintenance complex component 6; May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate
4176 MCM7 4176 HGNC:6950 Hs.438720 208795_s_at
210983_s_at
minichromosome maintenance complex component 7 Minichromosome maintenance complex component 7 ENSG00000166508 ENSP00000307288 hsa+4176 MCM7 MCM2 MCM7 7q21.3-q22.1 Approved CDC47 MCM7 minichromosome maintenance complex component 7; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage
84515 MCM8 84515 HGNC:16147 224320_s_at
233560_x_at
minichromosome maintenance complex component 8 ENSG00000125885 ENSP00000368174 MCM8 C20orf154 20p12.3 Approved MGC4816, MGC12866, MGC119522, MGC119523, dJ967N21.5, REC minichromosome maintenance complex component 8; May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle
4193 MDM2 4193 HGNC:6973 Hs.567303 205385_at
205386_s_at
211832_s_at
217373_x_at
217542_at
225160_x_at
229711_s_at
237891_at
244616_x_at
Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homolog (mouse) ENSG00000135679 ENSP00000417281 hsa+4193 MDM2 MDM2 12q13-q14 Approved HDM2, HDMX HDM2 Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
4998 ORC1L 4998 HGNC:8487 Hs.17908 205085_at
origin recognition complex, subunit 1-like (yeast) Origin recognition complex, subunit 1-like (yeast) ENSG00000085840 ENSP00000360621 hsa+4998 ORC1L ORC1L 1p32 Approved HSORC1, ORC1, PARC1 ORC1L origin recognition complex, subunit 1-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
4999 ORC2L 4999 HGNC:8488 Hs.444870 204853_at
235423_at
origin recognition complex, subunit 2-like (yeast) Origin recognition complex, subunit 2-like (yeast) ENSG00000115942 ENSP00000234296 hsa+4999 ORC2L ORC2L 2q33 Approved ORC2L origin recognition complex, subunit 2-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23595 ORC3L 23595 HGNC:8489 Hs.410228 210028_s_at
origin recognition complex, subunit 3-like (yeast) Origin recognition complex, subunit 3-like (yeast) ENSG00000135336 ENSP00000257789 hsa+23595 ORC3L ORC3L 6q Approved IMAGE50150, LATHEO ORC3L origin recognition complex, subunit 3-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5000 ORC4L 5000 HGNC:8490 Hs.558364 203351_s_at
203352_at
origin recognition complex, subunit 4-like (yeast) Origin recognition complex, subunit 4-like (yeast) ENSG00000115947 ENSP00000264169 hsa+5000 ORC4L ORC4L 2q22-q23 Approved HsORC4, ORC4, Orc4p Orc4p origin recognition complex, subunit 4-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5001 ORC5L 5001 HGNC:8491 Hs.432948 204957_at
211212_s_at
211213_at
origin recognition complex, subunit 5-like (yeast) Origin recognition complex, subunit 5-like (yeast) ENSG00000164815 ENSP00000297431 hsa+5001 ORC5L ORC5L 7q22.1 Approved Orc5p, ORC5, ORC5T Orc5p origin recognition complex, subunit 5-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23594 ORC6L 23594 HGNC:17151 Hs.49760 219105_x_at
origin recognition complex, subunit 6 like (yeast) Origin recognition complex, subunit 6 like (yeast) ENSG00000091651 ENSP00000219097 hsa+23594 ORC6L ORC6L 16q12 Approved ORC6 ORC6 origin recognition complex, subunit 6 like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5682 PSMA1 5682 HGNC:9530 Hs.102798 201676_x_at
210759_s_at
211746_x_at
proteasome (prosome, macropain) subunit, alpha type, 1 Proteasome (prosome, macropain) subunit, alpha type, 1 ENSG00000129084 ENSP00000315309 PSMA1 PSMA1 11p15.1 Approved HC2, NU, PROS30, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5683 PSMA2 5683 HGNC:9531 Hs.333786 201316_at
201317_s_at
53202_at
proteasome (prosome, macropain) subunit, alpha type, 2 Proteasome (prosome, macropain) subunit, alpha type, 2 ENSG00000106588 ENSP00000223321 PSMA2 PSMA2 7p13 Approved MU, HC3, PMSA2 PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation
5684 PSMA3 5684 HGNC:9532 Hs.558799 201532_at
232648_at
237300_at
proteasome (prosome, macropain) subunit, alpha type, 3 Proteasome (prosome, macropain) subunit, alpha type, 3 ENSG00000100567 ENSP00000216455 PSMA3 PSMA3 14q23 Approved HC8 HC8 proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5685 PSMA4 5685 HGNC:9533 Hs.251531 203396_at
proteasome (prosome, macropain) subunit, alpha type, 4 Proteasome (prosome, macropain) subunit, alpha type, 4 ENSG00000041357 ENSP00000044462 PSMA4 PSMA4 15q24.1 Approved HC9, HsT17706 PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5686 PSMA5 5686 HGNC:9534 Hs.712557 201274_at
proteasome (prosome, macropain) subunit, alpha type, 5 Proteasome (prosome, macropain) subunit, alpha type, 5 ENSG00000143106 ENSP00000271308 PSMA5 PSMA5 1p13 Approved ZETA PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5687 PSMA6 5687 HGNC:9535 Hs.446260 208805_at
proteasome (prosome, macropain) subunit, alpha type, 6 Proteasome (prosome, macropain) subunit, alpha type, 6 ENSG00000100902 ENSP00000261479 PSMA6 PSMA6 14q13 Approved IOTA, PROS27, p27K, MGC22756, MGC2333, MGC23846 IOTA proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5688 PSMA7 5688 HGNC:9536 Hs.233952 201114_x_at
216088_s_at
proteasome (prosome, macropain) subunit, alpha type, 7 Proteasome (prosome, macropain) subunit, alpha type, 7 ENSG00000101182 ENSP00000359910 PSMA7 PSMA7 20q13.33 Approved XAPC7, C6, HSPC, RC6-1 PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
143471 PSMA8 143471 HGNC:22985 240091_at
proteasome (prosome, macropain) subunit, alpha type, 8 ENSP00000311121 PSMA8 18q11.2 Approved MGC26605, PSMA7L proteasome (prosome, macropain) subunit, alpha type, 8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). This may be a testis-specific subunit
5689 PSMB1 5689 HGNC:9537 Hs.352768 200876_s_at
214288_s_at
214289_at
proteasome (prosome, macropain) subunit, beta type, 1 Proteasome (prosome, macropain) subunit, beta type, 1 ENSG00000008018 ENSP00000262193 PSMB1 PSMB1 6q27 Approved PMSB1, HC5 PSMB1 proteasome (prosome, macropain) subunit, beta type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5699 PSMB10 5699 HGNC:9538 Hs.9661 202659_at
proteasome (prosome, macropain) subunit, beta type, 10 Proteasome (prosome, macropain) subunit, beta type, 10 ENSG00000205220 ENSP00000351314 PSMB10 MECL1 PSMB10 16q22.1 Approved LMP10, MGC1665, beta2i PSMB10 proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
122706 PSMB11 122706 HGNC:31963 proteasome (prosome, macropain) subunit, beta type, 11 ENSP00000386212 PSMB11 14q11.2 Approved beta5t proteasome (prosome, macropain) subunit, beta type, 11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMB11 plays a pivotal role in development of CD8- positive T cells (By similarity)
5690 PSMB2 5690 HGNC:9539 Hs.471441 200039_s_at
201404_x_at
231323_at
proteasome (prosome, macropain) subunit, beta type, 2 Proteasome (prosome, macropain) subunit, beta type, 2 ENSG00000126067 ENSP00000362334 PSMB2 PSMB2 1p34.2 Approved HC7-I PSMB2 proteasome (prosome, macropain) subunit, beta type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity
5691 PSMB3 5691 HGNC:9540 Hs.82793 201400_at
proteasome (prosome, macropain) subunit, beta type, 3 Proteasome (prosome, macropain) subunit, beta type, 3 ENSG00000108294 ENSP00000225426 PSMB3 PSMB3 17q12 Approved HC10-II, MGC4147 PSMB3 proteasome (prosome, macropain) subunit, beta type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5692 PSMB4 5692 HGNC:9541 Hs.89545 202243_s_at
202244_at
proteasome (prosome, macropain) subunit, beta type, 4 Proteasome (prosome, macropain) subunit, beta type, 4 ENSG00000159377 ENSP00000290541 PSMB4 PSMB4 1q21 Approved HN3, PROS26 PSMB4 proteasome (prosome, macropain) subunit, beta type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5693 PSMB5 5693 HGNC:9542 Hs.422990 208799_at
proteasome (prosome, macropain) subunit, beta type, 5 Proteasome (prosome, macropain) subunit, beta type, 5 ENSG00000100804 ENSP00000355325 PSMB5 PSMB5 14q11.2 Approved X, MB1 X proteasome (prosome, macropain) subunit, beta type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5694 PSMB6 5694 HGNC:9543 Hs.77060 208827_at
proteasome (prosome, macropain) subunit, beta type, 6 Proteasome (prosome, macropain) subunit, beta type, 6 ENSG00000142507 ENSP00000270586 PSMB6 PSMB6 17p13 Approved Y, DELTA PSMB6 proteasome (prosome, macropain) subunit, beta type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5695 PSMB7 5695 HGNC:9544 Hs.213470 200786_at
244801_at
proteasome (prosome, macropain) subunit, beta type, 7 Proteasome (prosome, macropain) subunit, beta type, 7 ENSG00000136930 ENSP00000259457 PSMB7 PSMB7 9q34.11-q34.12 Approved Z PSMB7 proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5696 PSMB8 5696 HGNC:9545 Hs.180062 209040_s_at
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) ENSG00000206234 ENSP00000406797 PSMB8 LMP7 PSMB8 6p21.3 Approved RING10, D6S216E, PSMB5i, beta5i ENSG00000206234 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
5698 PSMB9 5698 HGNC:9546 Hs.654585 204279_at
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) ENSG00000206296 ENSP00000396813 PSMB9 LMP2 PSMB9 6p21.3 Approved RING12, beta1i, PSMB6i ENSG00000206296 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
5700 PSMC1 5700 HGNC:9547 Hs.356654 204219_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 1 Proteasome (prosome, macropain) 26S subunit, ATPase, 1 ENSG00000100764 ENSP00000261303 PSMC1 PSMC1 14q32.11 Approved S4, p56 S4 proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5701 PSMC2 5701 HGNC:9548 Hs.437366 201067_at
201068_s_at
238020_at
proteasome (prosome, macropain) 26S subunit, ATPase, 2 Proteasome (prosome, macropain) 26S subunit, ATPase, 2 ENSG00000161057 ENSP00000292644 PSMC2 PSMC2 7q22.1-q22.3 Approved MSS1, S7, Nbla10058 S7 proteasome (prosome, macropain) 26S subunit, ATPase, 2; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation
5702 PSMC3 5702 HGNC:9549 Hs.250758 201267_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 3 Proteasome (prosome, macropain) 26S subunit, ATPase, 3 ENSG00000165916 ENSP00000298852 PSMC3 PSMC3 11p11.2 Approved TBP1 PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation
5704 PSMC4 5704 HGNC:9551 Hs.211594 201252_at
Proteasome (prosome, macropain) 26S subunit, ATPase, 4 ENSG00000013275 ENSP00000157812 PSMC4 MIP224 PSMC4 19q13.11-q13.13 Approved TBP7, S6, MGC8570, MGC13687, MGC23214 S6 proteasome (prosome, macropain) 26S subunit, ATPase, 4; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5705 PSMC5 5705 HGNC:9552 Hs.79387 209503_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 5 Proteasome (prosome, macropain) 26S subunit, ATPase, 5 ENSG00000087191 ENSP00000310572 PSMC5 PSMC5 17q23.3 Approved SUG1, p45/SUG, TBP10, p45, S8, TRIP1 PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5706 PSMC6 5706 HGNC:9553 Hs.156171 201699_at
proteasome (prosome, macropain) 26S subunit, ATPase, 6 Proteasome (prosome, macropain) 26S subunit, ATPase, 6 ENSG00000100519 ENSP00000401802 PSMC6 PSMC6 14q22.1 Approved p42 p42 proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5707 PSMD1 5707 HGNC:9554 Hs.3887 201198_s_at
201199_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 ENSG00000173692 ENSP00000309474 PSMD1 PSMD1 2q37.1 Approved S1, P112, Rpn2 S1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5716 PSMD10 5716 HGNC:9555 Hs.522752 1554577_a_at
219485_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ENSG00000101843 ENSP00000217958 PSMD10 PSMD10 Xq22.3 Approved p28 PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5717 PSMD11 5717 HGNC:9556 Hs.655396 208776_at
208777_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 ENSG00000108671 ENSP00000261712 PSMD11 PSMD11 17q12 Approved S9, p44.5, MGC3844, Rpn6 PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5718 PSMD12 5718 HGNC:9557 Hs.646575 202352_s_at
202353_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 ENSG00000197170 ENSP00000348442 PSMD12 PSMD12 17q24.3 Approved p55, Rpn5 PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5719 PSMD13 5719 HGNC:9558 Hs.134688 201232_s_at
201233_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 ENSG00000185627 ENSP00000396937 PSMD13 PSMD13 11p15.5 Approved p40.5, Rpn9 PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
10213 PSMD14 10213 HGNC:16889 Hs.567410 212296_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 ENSG00000115233 ENSP00000386541 PSMD14 PSMD14 2q14.3 Approved POH1, pad1, Rpn11 POH1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear
5708 PSMD2 5708 HGNC:9559 Hs.518464 200830_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 ENSG00000175166 ENSP00000310129 PSMD2 PSMD2 3q27.3 Approved S2, P97, TRAP2, MGC14274, Rpn1 PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5709 PSMD3 5709 HGNC:9560 Hs.12970 201388_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 ENSG00000108344 ENSP00000264639 PSMD3 PSMD3 17q21.2 Approved S3, P58, Rpn3 PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5710 PSMD4 5710 HGNC:9561 Hs.505059 200882_s_at
210459_at
210460_s_at
211609_x_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 ENSG00000159352 ENSP00000357879 PSMD4 PSMD4 1q21.2 Approved S5A, AF-1, AF, Rpn10 PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion
5711 PSMD5 5711 HGNC:9563 Hs.193725 203447_at
215546_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 ENSG00000095261 ENSP00000210313 PSMD5 PSMD5 9q34.11 Approved S5B, KIAA0072 PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; Belongs to the 26S multisubunit protease, which is required for ubiquitin-dependent proteolysis. Does not bind ubiquitin polymers
9861 PSMD6 9861 HGNC:9564 Hs.152536 1555884_at
202753_at
232284_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 ENSG00000163636 ENSP00000295901 PSMD6 PSMD6 3p14.1 Approved S10, p44S10, KIAA0107, Rpn7 PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5713 PSMD7 5713 HGNC:9565 Hs.440604 201705_at
238738_at
244515_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 ENSG00000103035 ENSP00000219313 PSMD7 PSMD7 16q22.3 Approved S12, P40, MOV34, Rpn8 PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5714 PSMD8 5714 HGNC:9566 Hs.78466 200820_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 ENSG00000099341 ENSP00000215071 PSMD8 PSMD8 19q13.2 Approved S14, Nin1p, p31, HIP6, HYPF, Rpn12 PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase
5715 PSMD9 5715 HGNC:9567 Hs.131151 207805_s_at
209334_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 ENSG00000110801 ENSP00000261817 PSMD9 PSMD9 12q24.31-q24.32 Approved p27, Rpn4 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5720 PSME1 5720 HGNC:9568 Hs.75348 200814_at
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) ENSG00000092010 ENSP00000372155 PSME1 PSME1 14q11.2 Approved IFI5111, PA28alpha PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
5721 PSME2 5721 HGNC:9569 Hs.434081 Hs.512410 201762_s_at
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Proteasome (prosome, macropain) activator subunit 2 (PA28 beta) ENSG00000100911 ENSP00000216802 PSME2 PSME2 14q11.2 Approved PA28beta PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
10197 PSME3 10197 HGNC:9570 Hs.152978 200987_x_at
200988_s_at
209852_x_at
209853_s_at
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) ENSG00000131467 ENSP00000293362 PSME3 PSME3 17q12-q21 Approved Ki, PA28-gamma, REG-GAMMA, PA28G PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin- like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2- dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be [...]
23198 PSME4 23198 HGNC:20635 212219_at
212220_at
212222_at
237180_at
proteasome (prosome, macropain) activator subunit 4 ENSG00000068878 ENSP00000384211 PSME4 2p16.1 Approved PA200, KIAA0077 proteasome (prosome, macropain) activator subunit 4; Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair
9491 PSMF1 9491 HGNC:9571 Hs.471917 201052_s_at
201053_s_at
235993_at
236012_at
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ENSG00000125818 ENSP00000327704 PSMF1 PSMF1 20p13 Approved PI31 PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31); Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28
5810 RAD1 5810 HGNC:9806 Hs.531879 204460_s_at
204461_x_at
210216_x_at
228535_at
235253_at
RAD1 homolog (S. pombe) RAD1 homolog (S. pombe) ENSG00000113456 ENSP00000340879 RAD1 RAD1 5p13 Approved HRAD1, REC1 ENSG00000113456 RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...]
5884 RAD17 5884 HGNC:9807 Hs.16184 207405_s_at
210826_x_at
211228_s_at
RAD17 homolog (S. pombe) RAD17 homolog (S. pombe) ENSG00000152942 ENSP00000370151 RAD17 RAD17 5q13 Approved Rad24, RAD17Sp, CCYC RAD17 RAD17 homolog (S. pombe); Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination
5883 RAD9A 5883 HGNC:9827 1562022_s_at
204828_at
RAD9 homolog A (S. pombe) ENSG00000172613 ENSP00000311360 RAD9A RAD9 11q13.1-q13.2 Approved RAD9 homolog A (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activit [...]
144715 RAD9B 144715 HGNC:21700 1553285_s_at
1564688_a_at
RAD9 homolog B (S. pombe) ENSG00000151164 ENSP00000376440 RAD9B 12q24.13 Approved FLJ40346 RAD9 homolog B (S. pombe)
5982 RFC2 5982 HGNC:9970 Hs.647062 1053_at
203696_s_at
replication factor C (activator 1) 2, 40kDa Replication factor C (activator 1) 2, 40kDa GO:0006297 ENSG00000049541 ENSP00000055077 hsa+5982 RFC2 RFC2 EXP 7q11.23 Approved A1, RFC40 RFC2 replication factor C (activator 1) 2, 40kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity)
5983 RFC3 5983 HGNC:9971 Hs.115474 204127_at
204128_s_at
231119_at
replication factor C (activator 1) 3, 38kDa Replication factor C (activator 1) 3, 38kDa GO:0006297 ENSG00000133119 ENSP00000369411 hsa+5983 RFC3 RFC3 EXP 13q13.2 Approved RFC38, MGC5276 RFC3 replication factor C (activator 1) 3, 38kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1
5984 RFC4 5984 HGNC:9972 Hs.714318 204023_at
replication factor C (activator 1) 4, 37kDa Replication factor C (activator 1) 4, 37kDa GO:0006297 ENSG00000163918 ENSP00000296273 hsa+5984 RFC4 RFC4 EXP 3q27 Approved A1, RFC37 RFC4 replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template
5985 RFC5 5985 HGNC:9973 Hs.506989 203209_at
203210_s_at
replication factor C (activator 1) 5, 36.5kDa Replication factor C (activator 1) 5, 36.5kDa GO:0006297 ENSG00000111445 ENSP00000408295 hsa+5985 RFC5 RFC5 EXP 12q24.3 Approved RFC36 RFC5 replication factor C (activator 1) 5, 36.5kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1
64326 RFWD2 64326 HGNC:17440 1552617_a_at
234950_s_at
ring finger and WD repeat domain 2 ENSG00000143207 ENSP00000356641 RFWD2 1q25.1-q25.2 Approved FLJ10416, COP1, RNF200 ring finger and WD repeat domain 2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activi [...]
6117 RPA1 6117 HGNC:10289 Hs.461925 201528_at
201529_s_at
236675_at
replication protein A1, 70kDa Replication protein A1, 70kDa GO:0000718 GO:0006297 ENSG00000132383 ENSP00000254719 hsa+6117 RPA1 RPA1 EXP 17p13.3 Approved REPA1, RPA70, HSSB, RF-A, RP-A MST075 replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing
6118 RPA2 6118 HGNC:10290 Hs.79411 201756_at
replication protein A2, 32kDa Replication protein A2, 32kDa GO:0000718 GO:0006297 ENSG00000117748 ENSP00000363021 hsa+6118 RPA2 RPA2 EXP 1p35 Approved RPA2 replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
6119 RPA3 6119 HGNC:10291 Hs.487540 209507_at
replication protein A3, 14kDa Replication protein A3, 14kDa GO:0000718 GO:0006297 ENSG00000106399 ENSP00000223129 hsa+6119 RPA3 RPA3 EXP 7 Approved REPA3 RPA3 replication protein A3, 14kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
6233 RPS27A 6233 HGNC:10417 Hs.311640 Hs.546292 200017_at
242214_at
244624_at
ribosomal protein S27a Ribosomal protein S27a ENSG00000143947 ENSP00000272317 RPS27A RPS27A 2p16 Approved UBCEP80, Uba80 UBB ribosomal protein S27a
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
7311 UBA52 7311 HGNC:12458 221700_s_at
ubiquitin A-52 residue ribosomal protein fusion product 1 ENSG00000221983 ENSP00000388107 UBA52 19p13.1-p12 Approved RPL40, CEP52, HUBCEP52, MGC57125, MGC126879, MGC126881, L40 ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair
7314 UBB 7314 HGNC:12463 Hs.356190 Hs.714712 200633_at
217144_at
ubiquitin B Similar to Os05g0242100 ENSG00000170315 ENSP00000304697 UBB UBB 17p12-p11.2 Approved MGC8385, FLJ25987 ENSG00000170315 ubiquitin B
7316 UBC 7316 HGNC:12468 Hs.520348 208980_s_at
211296_x_at
ubiquitin C Ubiquitin C ENSG00000150991 ENSP00000344818 UBC UBC 12q24.3 Approved UBC ubiquitin C
11065 UBE2C 11065 HGNC:15937 Hs.93002 202954_at
ubiquitin-conjugating enzyme E2C Ubiquitin-conjugating enzyme E2C ENSG00000175063 ENSP00000348838 UBE2C UBE2C 20q13.12 Approved UBCH10 UBE2C ubiquitin-conjugating enzyme E2C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
7321 UBE2D1 7321 HGNC:12474 Hs.129683 211764_s_at
214590_s_at
215957_at
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) ENSG00000072401 ENSP00000363019 UBE2D1 SFT UBE2D1 10q21.1 Approved UbcH5A, UBCH5, UBC4/5, E2(17)KB1 UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
7324 UBE2E1 7324 HGNC:12477 Hs.164853 212519_at
238958_at
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) ENSG00000170142 ENSP00000303709 UBE2E1 UBE2E1 3p24.2 Approved UbcH6 UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins
7465 WEE1 7465 HGNC:12761 Hs.249441 212533_at
215711_s_at
WEE1 homolog (S. pombe) WEE1 homolog (S. pombe) ENSG00000166483 ENSP00000402084 hsa+7465 WEE1 WEE1 11p15.3-p15.1 Approved WEE1 WEE1 homolog (S. pombe); May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs e [...]
117 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
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