NAME: Rb Tumor suppressor/Check. P. Sign. in Response to Damage

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
64682 ANAPC1 64682 HGNC:19988 Hs.436527 218575_at
229267_at
231973_s_at
anaphase promoting complex subunit 1 Anaphase promoting complex subunit 1 ENSG00000153107 ENSP00000339109 hsa+64682 ANAPC1 ANAPC1 2q12.1 Approved MCPR, TSG24, APC1 ANAPC1 anaphase promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
10393 ANAPC10 10393 HGNC:24077 Hs.480876 207845_s_at
241959_at
anaphase promoting complex subunit 10 Anaphase promoting complex subunit 10 ENSG00000164162 ENSP00000310071 hsa+10393 ANAPC10 ANAPC10 4q31 Approved APC10, DOC1, DKFZP564L0562 APC10 anaphase promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51529 ANAPC11 51529 HGNC:14452 Hs.534456 224010_at
226414_s_at
anaphase promoting complex subunit 11 APC11 anaphase promoting complex subunit 11 ENSG00000141552 ENSP00000349957 hsa+51529 ANAPC11 ANAPC11 17q25.3 Approved HSPC214, APC11, Apc11p, MGC882 APC11 anaphase promoting complex subunit 11; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex
29882 ANAPC2 29882 HGNC:19989 Hs.533262 218555_at
anaphase promoting complex subunit 2 Anaphase promoting complex subunit 2 ENSG00000176248 ENSP00000314004 hsa+29882 ANAPC2 ANAPC2 9q34.3 Approved APC2, KIAA1406 ANAPC2 anaphase promoting complex subunit 2; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
29945 ANAPC4 29945 HGNC:19990 Hs.152173 226917_s_at
232524_x_at
anaphase promoting complex subunit 4 Anaphase promoting complex subunit 4 ENSG00000053900 ENSP00000318775 hsa+29945 ANAPC4 ANAPC4 4p15.31 Approved APC4 ANAPC4 anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51433 ANAPC5 51433 HGNC:15713 Hs.7101 200098_s_at
208721_s_at
208722_s_at
211036_x_at
239651_at
anaphase promoting complex subunit 5 Anaphase promoting complex subunit 5 ENSG00000089053 ENSP00000261819 hsa+51433 ANAPC5 ANAPC5 12q24 Approved APC5 APC5 anaphase promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
51434 ANAPC7 51434 HGNC:17380 Hs.529280 225521_at
225554_s_at
anaphase promoting complex subunit 7 Anaphase promoting complex subunit 7 ENSG00000196510 ENSP00000394394 hsa+51434 ANAPC7 ANAPC7 12q13.12 Approved APC7 ANAPC7 anaphase promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
701 BUB1B 701 HGNC:1149 Hs.631699 203755_at
budding uninhibited by benzimidazoles 1 homolog beta (yeast) BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) ENSG00000156970 ENSP00000287598 hsa+701 BUB1B BUB1B 15q15 Approved BUBR1, MAD3L, Bub1A, SSK1 BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Negatively regulates PLK1 activity in interphase cel [...]
9184 BUB3 9184 HGNC:1151 Hs.418533 201456_s_at
201457_x_at
201458_s_at
209974_s_at
229827_at
budding uninhibited by benzimidazoles 3 homolog (yeast) BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) ENSG00000154473 ENSP00000357858 hsa+9184 BUB3 BUB3 10q24 Approved BUB3L BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast); Required for kinetochore localization of BUB1
8881 CDC16 8881 HGNC:1720 Hs.374127 202717_s_at
209658_at
209659_s_at
cell division cycle 16 homolog (S. cerevisiae) Cell division cycle 16 homolog (S. cerevisiae) ENSG00000130177 ENSP00000348554 hsa+8881 CDC16 CDC16 13q34 Approved APC6 CDC16 cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
991 CDC20 991 HGNC:1723 Hs.524947 202870_s_at
cell division cycle 20 homolog (S. cerevisiae) Cell division cycle 20 homolog (S. cerevisiae) ENSG00000117399 ENSP00000308450 hsa+991 CDC20 CDC20 1p34.1 Approved p55CDC, CDC20A CDC20 cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates
8697 CDC23 8697 HGNC:1724 Hs.153546 202892_at
223651_x_at
cell division cycle 23 homolog (S. cerevisiae) Cell division cycle 23 homolog (S. cerevisiae) ENSG00000094880 ENSP00000378350 hsa+8697 CDC23 CDC23 5q31 Approved APC8 APC8 cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
246184 CDC26 246184 HGNC:17839 Hs.530284 225422_at
cell division cycle 26 homolog (S. cerevisiae) Cell division cycle 26 homolog (S. cerevisiae) ENSG00000176386 ENSP00000363322 hsa+246184 CDC26 C9orf17 CDC26 9q32 Approved CDC26 cell division cycle 26 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex
996 CDC27 996 HGNC:1728 Hs.463295 217878_s_at
217879_at
217880_at
217881_s_at
cell division cycle 27 homolog (S. cerevisiae) Cell division cycle 27 homolog (S. cerevisiae) ENSG00000004897 ENSP00000399255 hsa+996 CDC27 D0S1430E, D17S978E CDC27 17q21.32 Approved APC3 APC3 cell division cycle 27 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
8379 MAD1L1 8379 HGNC:6762 Hs.654838 204857_at
MAD1 mitotic arrest deficient-like 1 (yeast) MAD1 mitotic arrest deficient-like 1 (yeast) ENSG00000002822 ENSP00000382562 hsa+8379 MAD1L1 MAD1L1 7p22 Approved HsMAD1, TXBP181, MAD1, PIG9, TP53I9 MAD1 MAD1 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery
4085 MAD2L1 4085 HGNC:6763 Hs.591697 1554768_a_at
203362_s_at
MAD2 mitotic arrest deficient-like 1 (yeast) MAD2 mitotic arrest deficient-like 1 (yeast) ENSG00000164109 ENSP00000296509 hsa+4085 MAD2L1 MAD2L1 4q27 Approved MAD2, HSMAD2 MAD2 MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate
11065 UBE2C 11065 HGNC:15937 Hs.93002 202954_at
ubiquitin-conjugating enzyme E2C Ubiquitin-conjugating enzyme E2C ENSG00000175063 ENSP00000348838 UBE2C UBE2C 20q13.12 Approved UBCH10 UBE2C ubiquitin-conjugating enzyme E2C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
7321 UBE2D1 7321 HGNC:12474 Hs.129683 211764_s_at
214590_s_at
215957_at
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) ENSG00000072401 ENSP00000363019 UBE2D1 SFT UBE2D1 10q21.1 Approved UbcH5A, UBCH5, UBC4/5, E2(17)KB1 UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
7324 UBE2E1 7324 HGNC:12477 Hs.164853 212519_at
238958_at
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) ENSG00000170142 ENSP00000303709 UBE2E1 UBE2E1 3p24.2 Approved UbcH6 UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins
19 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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