NAME: Regulation of DNA Replication

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
472 ATM 472 HGNC:795 Hs.367437 1553387_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
983 CDC2 983 HGNC:1722 Hs.334562 203213_at
cell division cycle 2, G1 to S and G2 to M Cell division cycle 2, G1 to S and G2 to M GO:0006916 ENSG00000170312 ENSP00000362917 hsa+983 CDC2 CDC2 IDA 10q21.2 Approved REACT_152 REACT_1538 REACT_6850 CDC28A ENSG00000170312 cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1019 CDK4 1019 HGNC:1773 Hs.95577 202246_s_at
cyclin-dependent kinase 4 Cyclin-dependent kinase 4 ENSG00000135446 ENSP00000257904 hsa+1019 CDK4 CDK4 12q13 Approved REACT_152 PSK-J3 CDK4 cyclin-dependent kinase 4; Probably involved in the control of the cell cycle
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
4661 MYT1 4661 HGNC:7622 Hs.279562 1556269_at
myelin transcription factor 1 Myelin transcription factor 1 ENSG00000196132 ENSP00000327465 MYT1 PLPB1 MYT1 20q13.33 Approved MTF1, MYTI ENSG00000196132 myelin transcription factor 1; Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription
5923 RASGRF1 5923 HGNC:9875 1554992_at
Ras protein-specific guanine nucleotide-releasing factor 1 ENSG00000058335 ENSP00000405963 RASGRF1 GRF1 15q24 Approved CDC25L, CDC25, GRF55, H-GRF55, GNRP, PP13187 Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP
5925 RB1 5925 HGNC:9884 Hs.408528 203132_at
retinoblastoma 1 Retinoblastoma 1 ENSG00000139687 ENSP00000267163 hsa+5925 RB1 OSRC RB1 13q14.2 Approved REACT_152 REACT_383 RB1 retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repres [...]
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
7465 WEE1 7465 HGNC:12761 Hs.249441 212533_at
WEE1 homolog (S. pombe) WEE1 homolog (S. pombe) ENSG00000166483 ENSP00000402084 hsa+7465 WEE1 WEE1 11p15.3-p15.1 Approved WEE1 WEE1 homolog (S. pombe); May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs e [...]
7533 YWHAH 7533 HGNC:12853 Hs.226755 201020_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide ENSG00000128245 ENSP00000248975 hsa+7533 YWHAH YWHA1 YWHAH 22q12.1-q13.1 Approved YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner
13 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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