NAME: G2/M checkpoint

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
8900 CCNA1 8900 HGNC:1577 Hs.417050 205899_at
cyclin A1 Cyclin A1 ENSG00000133101 ENSP00000255465 hsa+8900 CCNA1 CCNA1 13q12.3-q13 Approved CCNA1 cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells
890 CCNA2 890 HGNC:1578 Hs.58974 203418_at
213226_at
cyclin A2 Cyclin A2 ENSG00000145386 ENSP00000274026 hsa+890 CCNA2 CCNA, CCN1 CCNA2 4q25-q31 Approved REACT_152 REACT_383 REACT_6850 CCNA2 cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions
990 CDC6 990 HGNC:1744 Hs.405958 203967_at
203968_s_at
cell division cycle 6 homolog (S. cerevisiae) Cell division cycle 6 homolog (S. cerevisiae) ENSG00000094804 ENSP00000209728 hsa+990 CDC6 CDC18L CDC6 17q21.3 Approved CDC6 cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1027 CDKN1B 1027 HGNC:1785 Hs.238990 209112_at
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cyclin-dependent kinase inhibitor 1B (p27, Kip1) GO:0006917 ENSG00000111276 ENSP00000228872 hsa+1027 CDKN1B CDKN1B IDA 12p13.1-p12 Approved KIP1, P27KIP1 KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events
81620 CDT1 81620 HGNC:24576 Hs.122908 209832_s_at
228868_x_at
chromatin licensing and DNA replication factor 1 Chromatin licensing and DNA replication factor 1 ENSG00000167513 ENSP00000301019 CDT1 CDT1 16q24.3 Approved DUP, RIS2 CDT1 chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
1870 E2F2 1870 HGNC:3114 Hs.194333 207042_at
228361_at
235582_at
E2F transcription factor 2 E2F transcription factor 2 ENSG00000007968 ENSP00000355249 hsa+1870 E2F2 E2F2 1p36 Approved E2F-2 E2F2 E2F transcription factor 2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner
1871 E2F3 1871 HGNC:3115 Hs.269408 Hs.703174 203692_s_at
203693_s_at
E2F transcription factor 3 E2F transcription factor 3 ENSG00000112242 ENSP00000262904 hsa+1871 E2F3 E2F3 6p22 Approved E2F3 E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner
51343 FZR1 51343 HGNC:24824 Hs.413133 209414_at
209415_at
209416_s_at
211865_s_at
fizzy/cell division cycle 20 related 1 (Drosophila) Fizzy/cell division cycle 20 related 1 (Drosophila) ENSG00000105325 ENSP00000378529 hsa+51343 FZR1 FZR1 19p13.3 Approved HCDH1, CDH1, HCDH, FZR, FZR2, KIAA1242, CDC20C FZR1 fizzy/cell division cycle 20 related 1 (Drosophila); Regulates ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. The APC/C-Cdh1 dimeric complex is activated during anaphase and telophase and remains active in degrading substrates until onset of the next S phase
51053 GMNN 51053 HGNC:17493 Hs.234896 218350_s_at
geminin, DNA replication inhibitor Geminin, DNA replication inhibitor ENSG00000112312 ENSP00000230056 GMNN GMNN 6p21.32 Approved Gem GMNN geminin, DNA replication inhibitor; Inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle
55388 MCM10 55388 HGNC:18043 Hs.198363 220651_s_at
222962_s_at
223570_at
minichromosome maintenance complex component 10 Minichromosome maintenance complex component 10 ENSG00000065328 ENSP00000354945 MCM10 MCM10 10p13 Approved PRO2249, CNA43, DNA43 MCM10 minichromosome maintenance complex component 10; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication
4171 MCM2 4171 HGNC:6944 Hs.477481 202107_s_at
minichromosome maintenance complex component 2 Minichromosome maintenance complex component 2 ENSG00000073111 ENSP00000265056 hsa+4171 MCM2 CCNL1, CDCL1 MCM2 3q21 Approved D3S3194, KIAA0030, BM28, cdc19 BM28 minichromosome maintenance complex component 2; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division
4172 MCM3 4172 HGNC:6945 Hs.179565 201555_at
minichromosome maintenance complex component 3 Minichromosome maintenance complex component 3 ENSG00000112118 ENSP00000229854 hsa+4172 MCM3 MCM3 6p12 Approved MCM3 minichromosome maintenance complex component 3; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation
4173 MCM4 4173 HGNC:6947 Hs.460184 212141_at
212142_at
222036_s_at
222037_at
minichromosome maintenance complex component 4 Minichromosome maintenance complex component 4 ENSG00000104738 ENSP00000262105 hsa+4173 MCM4 CDC21 MCM4 8q12-q13 Approved CDC54, hCdc21, P1-Cdc21, MGC33310 MCM4 minichromosome maintenance complex component 4; Involved in the control of DNA replication
4174 MCM5 4174 HGNC:6948 Hs.517582 201755_at
216237_s_at
minichromosome maintenance complex component 5 Minichromosome maintenance complex component 5 ENSG00000100297 ENSP00000216122 hsa+4174 MCM5 CDC46 MCM5 22q13.1-q13.2 Approved MCM5 minichromosome maintenance complex component 5
4175 MCM6 4175 HGNC:6949 Hs.444118 201930_at
238977_at
minichromosome maintenance complex component 6 Minichromosome maintenance complex component 6 ENSG00000076003 ENSP00000264156 hsa+4175 MCM6 MCM6 2q14-q21 Approved Mis5 MCM6 minichromosome maintenance complex component 6; May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate
4176 MCM7 4176 HGNC:6950 Hs.438720 208795_s_at
210983_s_at
minichromosome maintenance complex component 7 Minichromosome maintenance complex component 7 ENSG00000166508 ENSP00000307288 hsa+4176 MCM7 MCM2 MCM7 7q21.3-q22.1 Approved CDC47 MCM7 minichromosome maintenance complex component 7; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage
84515 MCM8 84515 HGNC:16147 224320_s_at
233560_x_at
minichromosome maintenance complex component 8 ENSG00000125885 ENSP00000368174 MCM8 C20orf154 20p12.3 Approved MGC4816, MGC12866, MGC119522, MGC119523, dJ967N21.5, REC minichromosome maintenance complex component 8; May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle
4998 ORC1L 4998 HGNC:8487 Hs.17908 205085_at
origin recognition complex, subunit 1-like (yeast) Origin recognition complex, subunit 1-like (yeast) ENSG00000085840 ENSP00000360621 hsa+4998 ORC1L ORC1L 1p32 Approved HSORC1, ORC1, PARC1 ORC1L origin recognition complex, subunit 1-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
4999 ORC2L 4999 HGNC:8488 Hs.444870 204853_at
235423_at
origin recognition complex, subunit 2-like (yeast) Origin recognition complex, subunit 2-like (yeast) ENSG00000115942 ENSP00000234296 hsa+4999 ORC2L ORC2L 2q33 Approved ORC2L origin recognition complex, subunit 2-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23595 ORC3L 23595 HGNC:8489 Hs.410228 210028_s_at
origin recognition complex, subunit 3-like (yeast) Origin recognition complex, subunit 3-like (yeast) ENSG00000135336 ENSP00000257789 hsa+23595 ORC3L ORC3L 6q Approved IMAGE50150, LATHEO ORC3L origin recognition complex, subunit 3-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5000 ORC4L 5000 HGNC:8490 Hs.558364 203351_s_at
203352_at
origin recognition complex, subunit 4-like (yeast) Origin recognition complex, subunit 4-like (yeast) ENSG00000115947 ENSP00000264169 hsa+5000 ORC4L ORC4L 2q22-q23 Approved HsORC4, ORC4, Orc4p Orc4p origin recognition complex, subunit 4-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5001 ORC5L 5001 HGNC:8491 Hs.432948 204957_at
211212_s_at
211213_at
origin recognition complex, subunit 5-like (yeast) Origin recognition complex, subunit 5-like (yeast) ENSG00000164815 ENSP00000297431 hsa+5001 ORC5L ORC5L 7q22.1 Approved Orc5p, ORC5, ORC5T Orc5p origin recognition complex, subunit 5-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23594 ORC6L 23594 HGNC:17151 Hs.49760 219105_x_at
origin recognition complex, subunit 6 like (yeast) Origin recognition complex, subunit 6 like (yeast) ENSG00000091651 ENSP00000219097 hsa+23594 ORC6L ORC6L 16q12 Approved ORC6 ORC6 origin recognition complex, subunit 6 like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5682 PSMA1 5682 HGNC:9530 Hs.102798 201676_x_at
210759_s_at
211746_x_at
proteasome (prosome, macropain) subunit, alpha type, 1 Proteasome (prosome, macropain) subunit, alpha type, 1 ENSG00000129084 ENSP00000315309 PSMA1 PSMA1 11p15.1 Approved HC2, NU, PROS30, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5683 PSMA2 5683 HGNC:9531 Hs.333786 201316_at
201317_s_at
53202_at
proteasome (prosome, macropain) subunit, alpha type, 2 Proteasome (prosome, macropain) subunit, alpha type, 2 ENSG00000106588 ENSP00000223321 PSMA2 PSMA2 7p13 Approved MU, HC3, PMSA2 PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation
5684 PSMA3 5684 HGNC:9532 Hs.558799 201532_at
232648_at
237300_at
proteasome (prosome, macropain) subunit, alpha type, 3 Proteasome (prosome, macropain) subunit, alpha type, 3 ENSG00000100567 ENSP00000216455 PSMA3 PSMA3 14q23 Approved HC8 HC8 proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5685 PSMA4 5685 HGNC:9533 Hs.251531 203396_at
proteasome (prosome, macropain) subunit, alpha type, 4 Proteasome (prosome, macropain) subunit, alpha type, 4 ENSG00000041357 ENSP00000044462 PSMA4 PSMA4 15q24.1 Approved HC9, HsT17706 PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5686 PSMA5 5686 HGNC:9534 Hs.712557 201274_at
proteasome (prosome, macropain) subunit, alpha type, 5 Proteasome (prosome, macropain) subunit, alpha type, 5 ENSG00000143106 ENSP00000271308 PSMA5 PSMA5 1p13 Approved ZETA PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5687 PSMA6 5687 HGNC:9535 Hs.446260 208805_at
proteasome (prosome, macropain) subunit, alpha type, 6 Proteasome (prosome, macropain) subunit, alpha type, 6 ENSG00000100902 ENSP00000261479 PSMA6 PSMA6 14q13 Approved IOTA, PROS27, p27K, MGC22756, MGC2333, MGC23846 IOTA proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5688 PSMA7 5688 HGNC:9536 Hs.233952 201114_x_at
216088_s_at
proteasome (prosome, macropain) subunit, alpha type, 7 Proteasome (prosome, macropain) subunit, alpha type, 7 ENSG00000101182 ENSP00000359910 PSMA7 PSMA7 20q13.33 Approved XAPC7, C6, HSPC, RC6-1 PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
143471 PSMA8 143471 HGNC:22985 240091_at
proteasome (prosome, macropain) subunit, alpha type, 8 ENSP00000311121 PSMA8 18q11.2 Approved MGC26605, PSMA7L proteasome (prosome, macropain) subunit, alpha type, 8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). This may be a testis-specific subunit
5689 PSMB1 5689 HGNC:9537 Hs.352768 200876_s_at
214288_s_at
214289_at
proteasome (prosome, macropain) subunit, beta type, 1 Proteasome (prosome, macropain) subunit, beta type, 1 ENSG00000008018 ENSP00000262193 PSMB1 PSMB1 6q27 Approved PMSB1, HC5 PSMB1 proteasome (prosome, macropain) subunit, beta type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5699 PSMB10 5699 HGNC:9538 Hs.9661 202659_at
proteasome (prosome, macropain) subunit, beta type, 10 Proteasome (prosome, macropain) subunit, beta type, 10 ENSG00000205220 ENSP00000351314 PSMB10 MECL1 PSMB10 16q22.1 Approved LMP10, MGC1665, beta2i PSMB10 proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
122706 PSMB11 122706 HGNC:31963 proteasome (prosome, macropain) subunit, beta type, 11 ENSP00000386212 PSMB11 14q11.2 Approved beta5t proteasome (prosome, macropain) subunit, beta type, 11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMB11 plays a pivotal role in development of CD8- positive T cells (By similarity)
5690 PSMB2 5690 HGNC:9539 Hs.471441 200039_s_at
201404_x_at
231323_at
proteasome (prosome, macropain) subunit, beta type, 2 Proteasome (prosome, macropain) subunit, beta type, 2 ENSG00000126067 ENSP00000362334 PSMB2 PSMB2 1p34.2 Approved HC7-I PSMB2 proteasome (prosome, macropain) subunit, beta type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity
5691 PSMB3 5691 HGNC:9540 Hs.82793 201400_at
proteasome (prosome, macropain) subunit, beta type, 3 Proteasome (prosome, macropain) subunit, beta type, 3 ENSG00000108294 ENSP00000225426 PSMB3 PSMB3 17q12 Approved HC10-II, MGC4147 PSMB3 proteasome (prosome, macropain) subunit, beta type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5692 PSMB4 5692 HGNC:9541 Hs.89545 202243_s_at
202244_at
proteasome (prosome, macropain) subunit, beta type, 4 Proteasome (prosome, macropain) subunit, beta type, 4 ENSG00000159377 ENSP00000290541 PSMB4 PSMB4 1q21 Approved HN3, PROS26 PSMB4 proteasome (prosome, macropain) subunit, beta type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5693 PSMB5 5693 HGNC:9542 Hs.422990 208799_at
proteasome (prosome, macropain) subunit, beta type, 5 Proteasome (prosome, macropain) subunit, beta type, 5 ENSG00000100804 ENSP00000355325 PSMB5 PSMB5 14q11.2 Approved X, MB1 X proteasome (prosome, macropain) subunit, beta type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5694 PSMB6 5694 HGNC:9543 Hs.77060 208827_at
proteasome (prosome, macropain) subunit, beta type, 6 Proteasome (prosome, macropain) subunit, beta type, 6 ENSG00000142507 ENSP00000270586 PSMB6 PSMB6 17p13 Approved Y, DELTA PSMB6 proteasome (prosome, macropain) subunit, beta type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5695 PSMB7 5695 HGNC:9544 Hs.213470 200786_at
244801_at
proteasome (prosome, macropain) subunit, beta type, 7 Proteasome (prosome, macropain) subunit, beta type, 7 ENSG00000136930 ENSP00000259457 PSMB7 PSMB7 9q34.11-q34.12 Approved Z PSMB7 proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5696 PSMB8 5696 HGNC:9545 Hs.180062 209040_s_at
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) ENSG00000206234 ENSP00000406797 PSMB8 LMP7 PSMB8 6p21.3 Approved RING10, D6S216E, PSMB5i, beta5i ENSG00000206234 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
5698 PSMB9 5698 HGNC:9546 Hs.654585 204279_at
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) ENSG00000206296 ENSP00000396813 PSMB9 LMP2 PSMB9 6p21.3 Approved RING12, beta1i, PSMB6i ENSG00000206296 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
5700 PSMC1 5700 HGNC:9547 Hs.356654 204219_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 1 Proteasome (prosome, macropain) 26S subunit, ATPase, 1 ENSG00000100764 ENSP00000261303 PSMC1 PSMC1 14q32.11 Approved S4, p56 S4 proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5701 PSMC2 5701 HGNC:9548 Hs.437366 201067_at
201068_s_at
238020_at
proteasome (prosome, macropain) 26S subunit, ATPase, 2 Proteasome (prosome, macropain) 26S subunit, ATPase, 2 ENSG00000161057 ENSP00000292644 PSMC2 PSMC2 7q22.1-q22.3 Approved MSS1, S7, Nbla10058 S7 proteasome (prosome, macropain) 26S subunit, ATPase, 2; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation
5702 PSMC3 5702 HGNC:9549 Hs.250758 201267_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 3 Proteasome (prosome, macropain) 26S subunit, ATPase, 3 ENSG00000165916 ENSP00000298852 PSMC3 PSMC3 11p11.2 Approved TBP1 PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation
5704 PSMC4 5704 HGNC:9551 Hs.211594 201252_at
Proteasome (prosome, macropain) 26S subunit, ATPase, 4 ENSG00000013275 ENSP00000157812 PSMC4 MIP224 PSMC4 19q13.11-q13.13 Approved TBP7, S6, MGC8570, MGC13687, MGC23214 S6 proteasome (prosome, macropain) 26S subunit, ATPase, 4; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5705 PSMC5 5705 HGNC:9552 Hs.79387 209503_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 5 Proteasome (prosome, macropain) 26S subunit, ATPase, 5 ENSG00000087191 ENSP00000310572 PSMC5 PSMC5 17q23.3 Approved SUG1, p45/SUG, TBP10, p45, S8, TRIP1 PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5706 PSMC6 5706 HGNC:9553 Hs.156171 201699_at
proteasome (prosome, macropain) 26S subunit, ATPase, 6 Proteasome (prosome, macropain) 26S subunit, ATPase, 6 ENSG00000100519 ENSP00000401802 PSMC6 PSMC6 14q22.1 Approved p42 p42 proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5707 PSMD1 5707 HGNC:9554 Hs.3887 201198_s_at
201199_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 ENSG00000173692 ENSP00000309474 PSMD1 PSMD1 2q37.1 Approved S1, P112, Rpn2 S1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5716 PSMD10 5716 HGNC:9555 Hs.522752 1554577_a_at
219485_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ENSG00000101843 ENSP00000217958 PSMD10 PSMD10 Xq22.3 Approved p28 PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5717 PSMD11 5717 HGNC:9556 Hs.655396 208776_at
208777_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 ENSG00000108671 ENSP00000261712 PSMD11 PSMD11 17q12 Approved S9, p44.5, MGC3844, Rpn6 PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5718 PSMD12 5718 HGNC:9557 Hs.646575 202352_s_at
202353_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 ENSG00000197170 ENSP00000348442 PSMD12 PSMD12 17q24.3 Approved p55, Rpn5 PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5719 PSMD13 5719 HGNC:9558 Hs.134688 201232_s_at
201233_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 ENSG00000185627 ENSP00000396937 PSMD13 PSMD13 11p15.5 Approved p40.5, Rpn9 PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
10213 PSMD14 10213 HGNC:16889 Hs.567410 212296_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 ENSG00000115233 ENSP00000386541 PSMD14 PSMD14 2q14.3 Approved POH1, pad1, Rpn11 POH1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear
5708 PSMD2 5708 HGNC:9559 Hs.518464 200830_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 ENSG00000175166 ENSP00000310129 PSMD2 PSMD2 3q27.3 Approved S2, P97, TRAP2, MGC14274, Rpn1 PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5709 PSMD3 5709 HGNC:9560 Hs.12970 201388_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 ENSG00000108344 ENSP00000264639 PSMD3 PSMD3 17q21.2 Approved S3, P58, Rpn3 PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5710 PSMD4 5710 HGNC:9561 Hs.505059 200882_s_at
210459_at
210460_s_at
211609_x_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 ENSG00000159352 ENSP00000357879 PSMD4 PSMD4 1q21.2 Approved S5A, AF-1, AF, Rpn10 PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion
5711 PSMD5 5711 HGNC:9563 Hs.193725 203447_at
215546_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 ENSG00000095261 ENSP00000210313 PSMD5 PSMD5 9q34.11 Approved S5B, KIAA0072 PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; Belongs to the 26S multisubunit protease, which is required for ubiquitin-dependent proteolysis. Does not bind ubiquitin polymers
9861 PSMD6 9861 HGNC:9564 Hs.152536 1555884_at
202753_at
232284_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 ENSG00000163636 ENSP00000295901 PSMD6 PSMD6 3p14.1 Approved S10, p44S10, KIAA0107, Rpn7 PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5713 PSMD7 5713 HGNC:9565 Hs.440604 201705_at
238738_at
244515_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 ENSG00000103035 ENSP00000219313 PSMD7 PSMD7 16q22.3 Approved S12, P40, MOV34, Rpn8 PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5714 PSMD8 5714 HGNC:9566 Hs.78466 200820_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 ENSG00000099341 ENSP00000215071 PSMD8 PSMD8 19q13.2 Approved S14, Nin1p, p31, HIP6, HYPF, Rpn12 PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase
5715 PSMD9 5715 HGNC:9567 Hs.131151 207805_s_at
209334_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 ENSG00000110801 ENSP00000261817 PSMD9 PSMD9 12q24.31-q24.32 Approved p27, Rpn4 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5720 PSME1 5720 HGNC:9568 Hs.75348 200814_at
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) ENSG00000092010 ENSP00000372155 PSME1 PSME1 14q11.2 Approved IFI5111, PA28alpha PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
5721 PSME2 5721 HGNC:9569 Hs.434081 Hs.512410 201762_s_at
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Proteasome (prosome, macropain) activator subunit 2 (PA28 beta) ENSG00000100911 ENSP00000216802 PSME2 PSME2 14q11.2 Approved PA28beta PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
10197 PSME3 10197 HGNC:9570 Hs.152978 200987_x_at
200988_s_at
209852_x_at
209853_s_at
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) ENSG00000131467 ENSP00000293362 PSME3 PSME3 17q12-q21 Approved Ki, PA28-gamma, REG-GAMMA, PA28G PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin- like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2- dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be [...]
23198 PSME4 23198 HGNC:20635 212219_at
212220_at
212222_at
237180_at
proteasome (prosome, macropain) activator subunit 4 ENSG00000068878 ENSP00000384211 PSME4 2p16.1 Approved PA200, KIAA0077 proteasome (prosome, macropain) activator subunit 4; Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair
9491 PSMF1 9491 HGNC:9571 Hs.471917 201052_s_at
201053_s_at
235993_at
236012_at
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ENSG00000125818 ENSP00000327704 PSMF1 PSMF1 20p13 Approved PI31 PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31); Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28
5925 RB1 5925 HGNC:9884 Hs.408528 203132_at
211540_s_at
retinoblastoma 1 Retinoblastoma 1 ENSG00000139687 ENSP00000267163 hsa+5925 RB1 OSRC RB1 13q14.2 Approved REACT_152 REACT_383 RB1 retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repres [...]
6233 RPS27A 6233 HGNC:10417 Hs.311640 Hs.546292 200017_at
242214_at
244624_at
ribosomal protein S27a Ribosomal protein S27a ENSG00000143947 ENSP00000272317 RPS27A RPS27A 2p16 Approved UBCEP80, Uba80 UBB ribosomal protein S27a
7311 UBA52 7311 HGNC:12458 221700_s_at
ubiquitin A-52 residue ribosomal protein fusion product 1 ENSG00000221983 ENSP00000388107 UBA52 19p13.1-p12 Approved RPL40, CEP52, HUBCEP52, MGC57125, MGC126879, MGC126881, L40 ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair
7314 UBB 7314 HGNC:12463 Hs.356190 Hs.714712 200633_at
217144_at
ubiquitin B Similar to Os05g0242100 ENSG00000170315 ENSP00000304697 UBB UBB 17p12-p11.2 Approved MGC8385, FLJ25987 ENSG00000170315 ubiquitin B
7316 UBC 7316 HGNC:12468 Hs.520348 208980_s_at
211296_x_at
ubiquitin C Ubiquitin C ENSG00000150991 ENSP00000344818 UBC UBC 12q24.3 Approved UBC ubiquitin C
75 genes found.

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