NAME: Processing of DNA DSB ends Recruitment of Repair and Sig. Proteins

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
4049 LTA 4049 HGNC:6709 Hs.36 206975_at
lymphotoxin alpha (TNF superfamily, member 1) Lymphotoxin alpha (TNF superfamily, member 1) ENSG00000206330 ENSP00000372793 LTA TNFB LTA 6p21.3 Approved TNFSF1, LT ENSG00000206330 lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo
4214 MAP3K1 4214 HGNC:6848 Hs.657756 214786_at
225927_at
mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 ENSG00000095015 ENSP00000382423 MAP3K1 MEKK1 MAP3K1 5q11.2 Approved REACT_6900 MEKK, MAPKKK1 MEKK mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway
9020 MAP3K14 9020 HGNC:6853 Hs.404183 205192_at
mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 14 ENSG00000006062 ENSP00000342059 hsa+9020 MAP3K14 MAP3K14 17q21-q22 Approved NIK, HSNIK, FTDCR1B, HS HSNIK mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity)
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
10010 TANK 10010 HGNC:11562 Hs.556496 207616_s_at
209451_at
210458_s_at
TRAF family member-associated NFKB activator TRAF family member-associated NFKB activator ENSG00000136560 ENSP00000259075 TANK TRAF2 TANK 2q24-q31 Approved I-TRAF TANK TRAF family member-associated NFKB activator; Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity
7128 TNFAIP3 7128 HGNC:11896 202643_s_at
202644_s_at
tumor necrosis factor, alpha-induced protein 3 ENSG00000118503 ENSP00000237289 TNFAIP3 6q23-q25 Approved A20, OTUD7C tumor necrosis factor, alpha-induced protein 3; Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed c [...]
7133 TNFRSF1B 7133 HGNC:11917 Hs.256278 203508_at
tumor necrosis factor receptor superfamily, member 1B Tumor necrosis factor receptor superfamily, member 1B ENSG00000028137 ENSP00000365435 TNFRSF1B TNFR2 TNFRSF1B 1p36.22 Approved TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b TNFRSF1B tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity
7185 TRAF1 7185 HGNC:12031 Hs.531251 205599_at
235116_at
TNF receptor-associated factor 1 TNF receptor-associated factor 1 ENSG00000056558 ENSP00000362994 TRAF1 TRAF1 9q33-q34 Approved EBI6 TRAF1 TNF receptor-associated factor 1; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2
7186 TRAF2 7186 HGNC:12032 Hs.522506 204413_at
TNF receptor-associated factor 2 TNF receptor-associated factor 2 GO:0008633 ENSG00000127191 ENSP00000247668 hsa+7186 TRAF2 TRAF2 EXP 9q34 Approved REACT_578 TRAP3 ENSG00000127191 TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling
7187 TRAF3 7187 HGNC:12033 Hs.510528 208315_x_at
221571_at
TNF receptor-associated factor 3 TNF receptor-associated factor 3 ENSG00000131323 ENSP00000332468 TRAF3 TRAF3 14q32.32 Approved CAP-1, CD40bp, CRAF1, LAP1 TRAF3 TNF receptor-associated factor 3; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to be involved in activation of NF- kappa-B and JNK and in apoptosis. Is regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding. Seems to play a role T- cell dependent immune responses
10 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
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