NAME: tnfr1 Signaling Pathway

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
6868 ADAM17 6868 HGNC:195 205745_x_at
205746_s_at
213532_at
ADAM metallopeptidase domain 17 ENSG00000151694 ENSP00000309968 ADAM17 TACE 2p25 Approved cSVP, CD156B ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity)
9530 BAG4 9530 HGNC:940 Hs.194726 219624_at
222909_s_at
228189_at
BCL2-associated athanogene 4 BCL2-associated athanogene 4 ENSG00000156735 ENSP00000287322 BAG4 BAG4 8p11.23 Approved SODD BAG4 BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
330 BIRC3 330 HGNC:591 Hs.127799 210538_s_at
baculoviral IAP repeat-containing 3 Baculoviral IAP repeat-containing 3 ENSG00000023445 ENSP00000263464 hsa+330 BIRC3 API2 BIRC3 11q22 Approved cIAP2, hiap-1, MIHC, RNF49, MALT2 API2 baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
857 CAV1 857 HGNC:1527 203065_s_at
212097_at
caveolin 1, caveolae protein, 22kDa ENSG00000105974 ENSP00000339191 CAV1 CAV 7q31 Approved caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity)
1540 CYLD 1540 HGNC:2584 213295_at
214272_at
221903_s_at
221905_at
222142_at
39582_at
60084_at
cylindromatosis (turban tumor syndrome) ENSP00000308928 CYLD CYLD1 16q12-q13 Approved KIAA0849, USPL2 cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6
8772 FADD 8772 HGNC:3573 Hs.86131 202535_at
Fas (TNFRSF6)-associated via death domain Fas (TNFRSF6)-associated via death domain GO:0008633 ENSG00000168040 ENSP00000301838 hsa+8772 FADD FADD EXP 11q13.3 Approved REACT_578 MORT1, GIG3 FADD Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis
10399 GNB2L1 10399 HGNC:4399 Hs.5662 200651_at
222034_at
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 ENSG00000204628 ENSP00000366013 GNB2L1 GNB2L1 5q35.3 Approved Gnb2-rs1, RACK1, H12.3 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation
8567 MADD 8567 HGNC:6766 Hs.82548 210252_s_at
38398_at
MAP-kinase activating death domain MAP-kinase activating death domain GO:0042981 ENSG00000110514 ENSP00000310933 MADD MADD IMP 11p11.2 Approved DENN, KIAA0358, RAB3GEP MADD MAP-kinase activating death domain; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant a [...]
5606 MAP2K3 5606 HGNC:6843 Hs.514012 207667_s_at
215498_s_at
215499_at
mitogen-activated protein kinase kinase 3 Mitogen-activated protein kinase kinase 3 ENSG00000034152 ENSP00000345083 MAP2K3 PRKMK3 MAP2K3 17q11.2 Approved MEK3, MKK3, MAPKK3 MEK3 mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
5609 MAP2K7 5609 HGNC:6847 Hs.531754 209951_s_at
209952_s_at
216206_x_at
226023_at
226053_at
mitogen-activated protein kinase kinase 7 Mitogen-activated protein kinase kinase 7 ENSG00000076984 ENSP00000381066 MAP2K7 PRKMK7 MAP2K7 19p13.3-p13.2 Approved MKK7, Jnkk2 mitogen-activated protein kinase kinase 7; Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3
4214 MAP3K1 4214 HGNC:6848 Hs.657756 214786_at
225927_at
mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 ENSG00000095015 ENSP00000382423 MAP3K1 MEKK1 MAP3K1 5q11.2 Approved REACT_6900 MEKK, MAPKKK1 MEKK mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway
4215 MAP3K3 4215 HGNC:6855 203514_at
227131_at
243505_at
mitogen-activated protein kinase kinase kinase 3 ENSP00000354927 MAP3K3 MEKK3 17q Approved MAPKKK3 mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators
4217 MAP3K5 4217 HGNC:6857 Hs.186486 203836_s_at
203837_at
mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase 5 ENSG00000197442 ENSP00000351908 MAP3K5 MEKK5 MAP3K5 6q22.33 Approved MAPKKK5, ASK1 MAP3K5 mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death
6885 MAP3K7 6885 HGNC:6859 Hs.714773 206853_s_at
206854_s_at
211536_x_at
211537_x_at
mitogen-activated protein kinase kinase kinase 7 Mitogen-activated protein kinase kinase kinase 7 ENSG00000135341 ENSP00000358335 MAP3K7 TAK1 MAP3K7 6q15 Approved REACT_6900 MAP3K7 mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway
23118 MAP3K7IP2 23118 HGNC:17075 Hs.269775 210284_s_at
212184_s_at
mitogen-activated protein kinase kinase kinase 7 interacting protein 2 Mitogen-activated protein kinase kinase kinase 7 interacting protein 2 ENSG00000055208 ENSP00000356426 MAP3K7IP2 MAP3K7IP2 6q25.1 Approved TAB2, KIAA0733 MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway
5871 MAP4K2 5871 HGNC:6864 204936_at
mitogen-activated protein kinase kinase kinase kinase 2 ENSG00000168067 ENSP00000294066 MAP4K2 RAB8IP 11q13.1 Approved GCK, BL44 mitogen-activated protein kinase kinase kinase kinase 2; Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion
8491 MAP4K3 8491 HGNC:6865 218311_at
mitogen-activated protein kinase kinase kinase kinase 3 ENSG00000011566 ENSP00000263881 MAP4K3 RAB8IPL1 2p22.3 Approved GLK, MAPKKKK3 mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
11183 MAP4K5 11183 HGNC:6867 203552_at
203553_s_at
211081_s_at
mitogen-activated protein kinase kinase kinase kinase 5 ENSP00000414032 MAP4K5 14q11.2-q21 Approved KHS1, GCKR, KHS mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
203447 NRK 203447 HGNC:25391 227971_at
232771_at
Nik related kinase ENSG00000123572 ENSP00000414221 NRK Xq22.3 Approved DKFZp686A17109 Nik related kinase; May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity)
8439 NSMAF 8439 HGNC:8017 Hs.372000 1558775_s_at
203269_at
232148_at
232149_s_at
240056_at
neutral sphingomyelinase (N-SMase) activation associated factor Neutral sphingomyelinase (N-SMase) activation associated factor ENSG00000035681 ENSP00000411012 NSMAF NSMAF 8q12-q13 Approved FAN FAN neutral sphingomyelinase (N-SMase) activation associated factor; Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE
5584 PRKCI 5584 HGNC:9404 209677_at
209678_s_at
213518_at
protein kinase C, iota ENSG00000163558 ENSP00000295797 PRKCI DXS1179E 3q26.3 Approved PKCI protein kinase C, iota; Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubula [...]
5590 PRKCZ 5590 HGNC:9412 Hs.496255 1569748_at
202178_at
protein kinase C, zeta Protein kinase C, zeta ENSG00000067606 ENSP00000367830 PRKCZ PRKCZ 1p36.33-p36.2 Approved PKC2 PRKCZ protein kinase C, zeta; This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme
117584 RFFL 117584 HGNC:24821 1552649_a_at
1552651_a_at
1562603_at
1566171_at
228980_at
237919_at
242155_x_at
ring finger and FYVE-like domain containing 1 ENSG00000092871 ENSP00000326170 RFFL 17q12 Approved rififylin, fring, RNF189, RNF34L ring finger and FYVE-like domain containing 1; Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
6609 SMPD1 6609 HGNC:11120 Hs.498173 209420_s_at
216230_x_at
217171_at
sphingomyelin phosphodiesterase 1, acid lysosomal Sphingomyelin phosphodiesterase 1, acid lysosomal ENSG00000166311 ENSP00000340409 SMPD1 SMPD1 11p15.4-p15.1 Approved ASM sphingomyelin phosphodiesterase 1, acid lysosomal; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity
6610 SMPD2 6610 HGNC:11121 205622_at
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) ENSG00000135587 ENSP00000258052 SMPD2 6q21 Approved nSMase, ISC1 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF
8878 SQSTM1 8878 HGNC:11280 Hs.437277 201471_s_at
213112_s_at
217252_at
217255_at
239004_at
244804_at
sequestosome 1 Sequestosome 1 ENSG00000161011 ENSP00000374455 SQSTM1 PDB3, OSIL SQSTM1 5q35 Approved p62, p60, p62B, A170 p60 sequestosome 1; Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels
6772 STAT1 6772 HGNC:11362 Hs.642990 200887_s_at
209969_s_at
AFFX-HUMISGF3A-M97935_3_at
AFFX-HUMISGF3A-M97935_5_at
AFFX-HUMISGF3A-M97935_MA_at
AFFX-HUMISGF3A-M97935_MB_at
signal transducer and activator of transcription 1, 91kDa Signal transducer and activator of transcription 1, 91kDa ENSG00000115415 ENSP00000354394 STAT1 STAT1 2q32.2-q32.3 Approved STAT91, ISGF-3 STAT1 signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated gen [...]
10454 TAB1 10454 HGNC:18157 Hs.507681 203901_at
233679_at
235480_at
235827_at
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 ENSG00000100324 ENSP00000216160 MAP3K7IP1 MAP3K7IP1 MAP3K7IP1 22q13.1 Approved REACT_6900 TAB1 TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
7128 TNFAIP3 7128 HGNC:11896 202643_s_at
202644_s_at
tumor necrosis factor, alpha-induced protein 3 ENSG00000118503 ENSP00000237289 TNFAIP3 6q23-q25 Approved A20, OTUD7C tumor necrosis factor, alpha-induced protein 3; Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed c [...]
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
7133 TNFRSF1B 7133 HGNC:11917 Hs.256278 203508_at
tumor necrosis factor receptor superfamily, member 1B Tumor necrosis factor receptor superfamily, member 1B ENSG00000028137 ENSP00000365435 TNFRSF1B TNFR2 TNFRSF1B 1p36.22 Approved TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b TNFRSF1B tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity
23043 TNIK 23043 HGNC:30765 211828_s_at
213107_at
213109_at
239288_at
TRAF2 and NCK interacting kinase ENSG00000154310 ENSP00000399511 TNIK 3q26.31 Approved KIAA0551 TRAF2 and NCK interacting kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and is required to activate Wnt target genes expression. May act by phosphorylating TCF4/TCF7L2. May also play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation
8717 TRADD 8717 HGNC:12030 Hs.460996 1729_at
205641_s_at
213443_at
TNFRSF1A-associated via death domain TNFRSF1A-associated via death domain GO:0008633 ENSG00000102871 ENSP00000341268 hsa+8717 TRADD TRADD EXP 16q22 Approved REACT_578 Hs.89862 TRADD TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B
7185 TRAF1 7185 HGNC:12031 Hs.531251 205599_at
235116_at
TNF receptor-associated factor 1 TNF receptor-associated factor 1 ENSG00000056558 ENSP00000362994 TRAF1 TRAF1 9q33-q34 Approved EBI6 TRAF1 TNF receptor-associated factor 1; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2
7186 TRAF2 7186 HGNC:12032 Hs.522506 204413_at
TNF receptor-associated factor 2 TNF receptor-associated factor 2 GO:0008633 ENSG00000127191 ENSP00000247668 hsa+7186 TRAF2 TRAF2 EXP 9q34 Approved REACT_578 TRAP3 ENSG00000127191 TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling
7295 TXN 7295 HGNC:12435 208864_s_at
216609_at
thioredoxin ENSG00000136810 ENSP00000363641 TXN 9q31 Approved TRX thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity
40 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
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