NAME: tnfr2 Signaling Pathway

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
843 CASP10 843 HGNC:1500 Hs.5353 205467_at
210708_x_at
210955_at
211888_x_at
caspase 10, apoptosis-related cysteine peptidase Caspase 10, apoptosis-related cysteine peptidase GO:0008624 ENSG00000003400 ENSP00000286186 hsa+843 CASP10 CASP10 EXP 2q33-q34 Approved REACT_578 MCH4 CASP10 caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
8837 CFLAR 8837 HGNC:1876 Hs.390736 208485_x_at
209508_x_at
209939_x_at
210563_x_at
210564_x_at
211316_x_at
211317_s_at
211862_x_at
214486_x_at
214618_at
217654_at
237367_x_at
239629_at
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator ENSG00000003402 ENSP00000312455 hsa+8837 CFLAR CASP8AP1 CFLAR 2q33-q34 Approved CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT CFLAR CASP8 and FADD-like apoptosis regulator; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
8772 FADD 8772 HGNC:3573 Hs.86131 202535_at
Fas (TNFRSF6)-associated via death domain Fas (TNFRSF6)-associated via death domain GO:0008633 ENSG00000168040 ENSP00000301838 hsa+8772 FADD FADD EXP 11q13.3 Approved REACT_578 MORT1, GIG3 FADD Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis
355 FAS 355 HGNC:11920 Hs.244139 204780_s_at
204781_s_at
215719_x_at
216252_x_at
Fas (TNF receptor superfamily, member 6) Fas (TNF receptor superfamily, member 6) GO:0008624 GO:0008633 ENSG00000026103 ENSP00000347979 hsa+355 FAS FAS1, APT1, TNFRSF6 FAS EXP 10q24.1 Approved REACT_578 CD95, APO-1 FAS Fas (TNF receptor superfamily, member 6); Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)
356 FASLG 356 HGNC:11936 Hs.2007 210865_at
211333_s_at
Fas ligand (TNF superfamily, member 6) Fas ligand (TNF superfamily, member 6) GO:0008624 GO:0008633 ENSG00000117560 ENSP00000356694 hsa+356 FASLG APT1LG1, TNFSF6 FASLG EXP 1q23 Approved REACT_578 FasL, CD178 FASLG Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
8795 TNFRSF10B 8795 HGNC:11905 Hs.521456 209294_x_at
209295_at
210405_x_at
tumor necrosis factor receptor superfamily, member 10b Tumor necrosis factor receptor superfamily, member 10b GO:0008633 ENSG00000120889 ENSP00000276431 hsa+8795 TNFRSF10B TNFRSF10B EXP 8p22-p21 Approved REACT_578 DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
8743 TNFSF10 8743 HGNC:11925 Hs.478275 tumor necrosis factor (ligand) superfamily, member 10 Tumor necrosis factor (ligand) superfamily, member 10 GO:0008633 ENSG00000121858 ENSP00000241261 hsa+8743 TNFSF10 TNFSF10 EXP 3q26 Approved REACT_578 TRAIL, Apo-2L, TL2, CD253 TL2 tumor necrosis factor (ligand) superfamily, member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
8717 TRADD 8717 HGNC:12030 Hs.460996 1729_at
205641_s_at
213443_at
TNFRSF1A-associated via death domain TNFRSF1A-associated via death domain GO:0008633 ENSG00000102871 ENSP00000341268 hsa+8717 TRADD TRADD EXP 16q22 Approved REACT_578 Hs.89862 TRADD TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B
7186 TRAF2 7186 HGNC:12032 Hs.522506 204413_at
TNF receptor-associated factor 2 TNF receptor-associated factor 2 GO:0008633 ENSG00000127191 ENSP00000247668 hsa+7186 TRAF2 TRAF2 EXP 9q34 Approved REACT_578 TRAP3 ENSG00000127191 TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling
13 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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