NAME: TNF Receptor Signaling Pathway

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
572 BAD 572 HGNC:936 Hs.370254 1861_at
209364_at
232660_at
BCL2-associated agonist of cell death BCL2-associated agonist of cell death GO:0008633 ENSG00000002330 ENSP00000309103 hsa+572 BAD BAD EXP 11q13.1 Approved REACT_578 BCL2L8, BBC2 BAD BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
581 BAX 581 HGNC:959 Hs.631546 208478_s_at
211833_s_at
BCL2-associated X protein BCL2-associated X protein GO:0006917 GO:0006919 GO:0043525 ENSG00000087088 ENSP00000293288 hsa+581 BAX BAX IDA 19q13.3-q13.4 Approved REACT_578 BCL2L4 BAX BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
598 BCL2L1 598 HGNC:992 Hs.516966 206665_s_at
212312_at
215037_s_at
231228_at
BCL2-like 1 BCL2-like 1 GO:0001836 ENSG00000171552 ENSP00000302564 hsa+598 BCL2L1 BCL2L1 IDA 20q11.21 Approved REACT_578 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS BCL2L1 BCL2-like 1; Potent inhibitor of cell death. Isoform Bcl-X(L) anti- apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis
637 BID 637 HGNC:1050 Hs.591054 BH3 interacting domain death agonist BH3 interacting domain death agonist GO:0001836 GO:0008633 ENSG00000015475 ENSP00000318822 hsa+637 BID BID EXP IDA 22q11.2 Approved REACT_578 BID BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
839 CASP6 839 HGNC:1507 Hs.654616 209790_s_at
211464_x_at
caspase 6, apoptosis-related cysteine peptidase Caspase 6, apoptosis-related cysteine peptidase ENSG00000138794 ENSP00000265164 hsa+839 CASP6 CASP6 4q25 Approved MCH2 CASP6 caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
54205 CYCS 54205 HGNC:19986 Hs.437060 Hs.617193 cytochrome c, somatic Cytochrome c, somatic GO:0006309 GO:0006915 ENSG00000172115 ENSP00000307786 hsa+54205 CYCS CYCS IDA IMP 7p21.2 Approved REACT_578 REACT_6305 HCS CYCS cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
12 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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