NAME: Death Receptor Signalling

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
58 ACTA1 58 HGNC:129 Hs.1288 203872_at
actin, alpha 1, skeletal muscle Actin, alpha 1, skeletal muscle ENSG00000143632 ENSP00000355645 ACTA1 ACTA ACTA1 1q42.13 Approved ACTA1 actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (By similarity)
637 BID 637 HGNC:1050 Hs.591054 BH3 interacting domain death agonist BH3 interacting domain death agonist GO:0001836 GO:0008633 ENSG00000015475 ENSP00000318822 hsa+637 BID BID EXP IDA 22q11.2 Approved REACT_578 BID BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
843 CASP10 843 HGNC:1500 Hs.5353 205467_at
210708_x_at
210955_at
211888_x_at
caspase 10, apoptosis-related cysteine peptidase Caspase 10, apoptosis-related cysteine peptidase GO:0008624 ENSG00000003400 ENSP00000286186 hsa+843 CASP10 CASP10 EXP 2q33-q34 Approved REACT_578 MCH4 CASP10 caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
839 CASP6 839 HGNC:1507 Hs.654616 209790_s_at
211464_x_at
caspase 6, apoptosis-related cysteine peptidase Caspase 6, apoptosis-related cysteine peptidase ENSG00000138794 ENSP00000265164 hsa+839 CASP6 CASP6 4q25 Approved MCH2 CASP6 caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
1676 DFFA 1676 HGNC:2772 Hs.484782 203277_at
223518_at
226116_at
DNA fragmentation factor, 45kDa, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide GO:0006309 GO:0043066 ENSG00000160049 ENSP00000366237 hsa+1676 DFFA DFFA IDA 1p36.3-p36.2 Approved DFF-45, DFF45, ICAD, DFF1 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40)
1677 DFFB 1677 HGNC:2773 Hs.133089 206752_s_at
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) GO:0006309 GO:0030263 ENSG00000169598 ENSP00000367454 hsa+1677 DFFB DFFB IDA 1p36.3 Approved CAD, CPAN, DFF-40, DFF40 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
2620 GAS2 2620 HGNC:4167 Hs.632151 205848_at
growth arrest-specific 2 Growth arrest-specific 2 ENSG00000148935 ENSP00000278187 GAS2 GAS2 11p14.3 Approved GAS2 growth arrest-specific 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)
4000 LMNA 4000 HGNC:6636 Hs.594444 1554600_s_at
203411_s_at
212086_x_at
212089_at
214213_x_at
lamin A/C Lamin A/C ENSG00000160789 ENSP00000357283 LMNA LMN1, CMD1A, LGMD1B LMNA 1q22 Approved LMNA lamin A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals
9020 MAP3K14 9020 HGNC:6853 Hs.404183 205192_at
mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 14 ENSG00000006062 ENSP00000342059 hsa+9020 MAP3K14 MAP3K14 17q21-q22 Approved NIK, HSNIK, FTDCR1B, HS HSNIK mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity)
142 PARP1 142 HGNC:270 Hs.177766 208644_at
poly (ADP-ribose) polymerase 1 Poly (ADP-ribose) polymerase 1 ENSG00000143799 ENSP00000355759 hsa+142 PARP1 PPOL, ADPRT PARP1 1q41-q42 Approved PARP PARP1 poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
6709 SPTAN1 6709 HGNC:11273 Hs.372331 208611_s_at
214925_s_at
214926_at
215235_at
241150_at
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ENSG00000197694 ENSP00000361824 SPTAN1 SPTAN1 9q34.11 Approved SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
8797 TNFRSF10A 8797 HGNC:11904 Hs.591834 1552648_a_at
231775_at
241371_at
tumor necrosis factor receptor superfamily, member 10a Tumor necrosis factor receptor superfamily, member 10a ENSG00000104689 ENSP00000221132 hsa+8797 TNFRSF10A TNFRSF10A 8p21 Approved DR4, Apo2, TRAILR-1, CD261 TNFRSF10A tumor necrosis factor receptor superfamily, member 10a; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B
8795 TNFRSF10B 8795 HGNC:11905 Hs.521456 209294_x_at
209295_at
210405_x_at
tumor necrosis factor receptor superfamily, member 10b Tumor necrosis factor receptor superfamily, member 10b GO:0008633 ENSG00000120889 ENSP00000276431 hsa+8795 TNFRSF10B TNFRSF10B EXP 8p22-p21 Approved REACT_578 DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B
8718 TNFRSF25 8718 HGNC:11910 Hs.462529 210847_x_at
211282_x_at
211841_s_at
216042_at
219423_x_at
tumor necrosis factor receptor superfamily, member 25 Tumor necrosis factor receptor superfamily, member 25 ENSG00000215788 ENSP00000367013 TNFRSF25 TNFRSF12 TNFRSF25 1p36.2 Approved DR3, TRAMP, WSL-1, LARD, WSL-LR, DDR3, TR3, APO-3 - tumor necrosis factor receptor superfamily, member 25; Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis
8743 TNFSF10 8743 HGNC:11925 Hs.478275 tumor necrosis factor (ligand) superfamily, member 10 Tumor necrosis factor (ligand) superfamily, member 10 GO:0008633 ENSG00000121858 ENSP00000241261 hsa+8743 TNFSF10 TNFSF10 EXP 3q26 Approved REACT_578 TRAIL, Apo-2L, TL2, CD253 TL2 tumor necrosis factor (ligand) superfamily, member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
8742 TNFSF12 8742 HGNC:11927 205611_at
tumor necrosis factor (ligand) superfamily, member 12 ENSG00000161955 ENSP00000293826 TNFSF12 TNFSF12 17p13.1 Approved TWEAK, DR3LG, APO3L TNFSF12 tumor necrosis factor (ligand) superfamily, member 12; Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines
20 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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