NAME: Apoptotic signaling in response to dna damage

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
9131 AIFM1 9131 HGNC:8768 Hs.424932 205512_s_at
apoptosis-inducing factor, mitochondrion-associated, 1 Apoptosis-inducing factor, mitochondrion-associated, 1 ENSG00000156709 ENSP00000287295 hsa+9131 AIFM1 PDCD8 AIFM1 Xq26.1 Approved AIF AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1; Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
208 AKT2 208 HGNC:392 Hs.631535 1560689_s_at
203808_at
203809_s_at
211453_s_at
225471_s_at
226156_at
236664_at
v-akt murine thymoma viral oncogene homolog 2 V-akt murine thymoma viral oncogene homolog 2 ENSG00000105221 ENSP00000375892 hsa+208 AKT2 AKT2 19q13.1-q13.2 Approved REACT_1123 REACT_498 AKT2 v-akt murine thymoma viral oncogene homolog 2; General protein kinase capable of phosphorylating several known proteins
10000 AKT3 10000 HGNC:393 Hs.498292 212607_at
212609_s_at
219393_s_at
222880_at
224229_s_at
242876_at
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) ENSG00000117020 ENSP00000263826 hsa+10000 AKT3 AKT3 1q44 Approved PKBG, RAC-gamma, PRKBG AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent
317 APAF1 317 HGNC:576 Hs.708112 204859_s_at
211553_x_at
211554_s_at
apoptotic peptidase activating factor 1 Apoptotic peptidase activating factor 1 GO:0008635 ENSG00000120868 ENSP00000353059 hsa+317 APAF1 APAF1 IDA 12q23 Approved REACT_578 CED4, APAF-1 CED4 apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
572 BAD 572 HGNC:936 Hs.370254 1861_at
209364_at
232660_at
BCL2-associated agonist of cell death BCL2-associated agonist of cell death GO:0008633 ENSG00000002330 ENSP00000309103 hsa+572 BAD BAD EXP 11q13.1 Approved REACT_578 BCL2L8, BBC2 BAD BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
581 BAX 581 HGNC:959 Hs.631546 208478_s_at
211833_s_at
BCL2-associated X protein BCL2-associated X protein GO:0006917 GO:0006919 GO:0043525 ENSG00000087088 ENSP00000293288 hsa+581 BAX BAX IDA 19q13.3-q13.4 Approved REACT_578 BCL2L4 BAX BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
598 BCL2L1 598 HGNC:992 Hs.516966 206665_s_at
212312_at
215037_s_at
231228_at
BCL2-like 1 BCL2-like 1 GO:0001836 ENSG00000171552 ENSP00000302564 hsa+598 BCL2L1 BCL2L1 IDA 20q11.21 Approved REACT_578 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS BCL2L1 BCL2-like 1; Potent inhibitor of cell death. Isoform Bcl-X(L) anti- apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis
637 BID 637 HGNC:1050 Hs.591054 BH3 interacting domain death agonist BH3 interacting domain death agonist GO:0001836 GO:0008633 ENSG00000015475 ENSP00000318822 hsa+637 BID BID EXP IDA 22q11.2 Approved REACT_578 BID BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
330 BIRC3 330 HGNC:591 Hs.127799 210538_s_at
baculoviral IAP repeat-containing 3 Baculoviral IAP repeat-containing 3 ENSG00000023445 ENSP00000263464 hsa+330 BIRC3 API2 BIRC3 11q22 Approved cIAP2, hiap-1, MIHC, RNF49, MALT2 API2 baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
823 CAPN1 823 HGNC:1476 Hs.502842 200752_s_at
232012_at
calpain 1, (mu/I) large subunit Calpain 1, (mu/I) large subunit ENSG00000014216 ENSP00000279247 hsa+823 CAPN1 CAPN1 11q13 Approved muCANP, muCL, CANP, CANPL1 muCL calpain 1, (mu/I) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction
824 CAPN2 824 HGNC:1479 Hs.350899 208683_at
214888_at
calpain 2, (m/II) large subunit Calpain 2, (m/II) large subunit ENSG00000162909 ENSP00000295006 hsa+824 CAPN2 CAPN2 1q41-q42 Approved mCANP, CANPml, CANPL2 CAPN2 calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction
843 CASP10 843 HGNC:1500 Hs.5353 205467_at
210708_x_at
210955_at
211888_x_at
caspase 10, apoptosis-related cysteine peptidase Caspase 10, apoptosis-related cysteine peptidase GO:0008624 ENSG00000003400 ENSP00000286186 hsa+843 CASP10 CASP10 EXP 2q33-q34 Approved REACT_578 MCH4 CASP10 caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
839 CASP6 839 HGNC:1507 Hs.654616 209790_s_at
211464_x_at
caspase 6, apoptosis-related cysteine peptidase Caspase 6, apoptosis-related cysteine peptidase ENSG00000138794 ENSP00000265164 hsa+839 CASP6 CASP6 4q25 Approved MCH2 CASP6 caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
842 CASP9 842 HGNC:1511 Hs.329502 203984_s_at
210775_x_at
240437_at
caspase 9, apoptosis-related cysteine peptidase Caspase 9, apoptosis-related cysteine peptidase ENSG00000132906 ENSP00000330237 hsa+842 CASP9 CASP9 1p36.21 Approved REACT_578 MCH6, ICE-LAP6, APAF-3 CASP9 caspase 9, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
8837 CFLAR 8837 HGNC:1876 Hs.390736 208485_x_at
209508_x_at
209939_x_at
210563_x_at
210564_x_at
211316_x_at
211317_s_at
211862_x_at
214486_x_at
214618_at
217654_at
237367_x_at
239629_at
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator ENSG00000003402 ENSP00000312455 hsa+8837 CFLAR CASP8AP1 CFLAR 2q33-q34 Approved CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT CFLAR CASP8 and FADD-like apoptosis regulator; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
1147 CHUK 1147 HGNC:1974 Hs.198998 209666_s_at
conserved helix-loop-helix ubiquitous kinase Conserved helix-loop-helix ubiquitous kinase ENSG00000213341 ENSP00000359424 hsa+1147 CHUK TCF16 CHUK 10q24-q25 Approved REACT_6900 IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA - conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'S [...]
1439 CSF2RB 1439 HGNC:2436 Hs.592192 205159_at
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) ENSG00000100368 ENSP00000384053 hsa+1439 CSF2RB IL3RB CSF2RB 22q12.2-q13.1 Approved IL5RB, CD131 IL5RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor
54205 CYCS 54205 HGNC:19986 Hs.437060 Hs.617193 cytochrome c, somatic Cytochrome c, somatic GO:0006309 GO:0006915 ENSG00000172115 ENSP00000307786 hsa+54205 CYCS CYCS IDA IMP 7p21.2 Approved REACT_578 REACT_6305 HCS CYCS cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
1676 DFFA 1676 HGNC:2772 Hs.484782 203277_at
223518_at
226116_at
DNA fragmentation factor, 45kDa, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide GO:0006309 GO:0043066 ENSG00000160049 ENSP00000366237 hsa+1676 DFFA DFFA IDA 1p36.3-p36.2 Approved DFF-45, DFF45, ICAD, DFF1 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40)
1677 DFFB 1677 HGNC:2773 Hs.133089 206752_s_at
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) GO:0006309 GO:0030263 ENSG00000169598 ENSP00000367454 hsa+1677 DFFB DFFB IDA 1p36.3 Approved CAD, CPAN, DFF-40, DFF40 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
2021 ENDOG 2021 HGNC:3346 Hs.591905 204824_at
endonuclease G Endonuclease G ENSG00000167136 ENSP00000361725 hsa+2021 ENDOG ENDOG 9q34.1 Approved ENDOG endonuclease G; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity)
8772 FADD 8772 HGNC:3573 Hs.86131 202535_at
Fas (TNFRSF6)-associated via death domain Fas (TNFRSF6)-associated via death domain GO:0008633 ENSG00000168040 ENSP00000301838 hsa+8772 FADD FADD EXP 11q13.3 Approved REACT_578 MORT1, GIG3 FADD Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis
355 FAS 355 HGNC:11920 Hs.244139 204780_s_at
204781_s_at
215719_x_at
216252_x_at
Fas (TNF receptor superfamily, member 6) Fas (TNF receptor superfamily, member 6) GO:0008624 GO:0008633 ENSG00000026103 ENSP00000347979 hsa+355 FAS FAS1, APT1, TNFRSF6 FAS EXP 10q24.1 Approved REACT_578 CD95, APO-1 FAS Fas (TNF receptor superfamily, member 6); Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)
356 FASLG 356 HGNC:11936 Hs.2007 210865_at
211333_s_at
Fas ligand (TNF superfamily, member 6) Fas ligand (TNF superfamily, member 6) GO:0008624 GO:0008633 ENSG00000117560 ENSP00000356694 hsa+356 FASLG APT1LG1, TNFSF6 FASLG EXP 1q23 Approved REACT_578 FasL, CD178 FASLG Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
8517 IKBKG 8517 HGNC:5961 Hs.43505 209929_s_at
36004_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma ENSG00000073009 ENSP00000358622 hsa+8517 IKBKG IP2, IP1 IKBKG Xq28 Approved REACT_6900 IKK-gamma, NEMO, Fip3p, FIP-3, FIP3 IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)
3552 IL1A 3552 HGNC:5991 Hs.1722 208200_at
210118_s_at
interleukin 1, alpha Interleukin 1, alpha ENSG00000115008 ENSP00000263339 hsa+3552 IL1A IL1 IL1A 2q14 Approved IL1F1, IL-1A IL1 interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity)
3553 IL1B 3553 HGNC:5992 Hs.126256 205067_at
39402_at
interleukin 1, beta Interleukin 1, beta GO:0006916 ENSG00000125538 ENSP00000263341 hsa+3553 IL1B IL1B IDA 2q14 Approved IL1F2, IL-1B IL1B interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells
3554 IL1R1 3554 HGNC:5993 Hs.701982 202948_at
215561_s_at
interleukin 1 receptor, type I Interleukin 1 receptor, type I ENSG00000115594 ENSP00000233946 hsa+3554 IL1R1 IL1R, IL1RA IL1R1 2q12 Approved D2S1473, CD121A IL1R interleukin 1 receptor, type I; Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2
3556 IL1RAP 3556 HGNC:5995 Hs.478673 interleukin 1 receptor accessory protein Interleukin 1 receptor accessory protein ENSG00000196083 ENSP00000072516 hsa+3556 IL1RAP IL1RAP 3q28 Approved IL-1RAcP, IL1R3, C3orf13 IL1R3 interleukin 1 receptor accessory protein; Mediates interleukin-1-dependent activation of NF-kappa- B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor
3562 IL3 3562 HGNC:6011 Hs.694 207906_at
interleukin 3 (colony-stimulating factor, multiple) Interleukin 3 (colony-stimulating factor, multiple) ENSG00000164399 ENSP00000296870 hsa+3562 IL3 IL3 5q23-q31 Approved IL-3, MULTI-CSF, MCGF IL3 interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages
3563 IL3RA 3563 HGNC:6012 Hs.632790 206148_at
interleukin 3 receptor, alpha (low affinity) Interleukin 3 receptor, alpha (low affinity) ENSG00000185291 ENSP00000327890 hsa+3563 IL3RA IL3RA Xp22.3 and Yp13.3 Approved CD123 IL3RA interleukin 3 receptor, alpha (low affinity); This is a receptor for interleukin-3
3654 IRAK1 3654 HGNC:6112 Hs.522819 1555784_s_at
201587_s_at
interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 1 ENSG00000184216 ENSP00000358997 hsa+3654 IRAK1 IRAK1 Xq28 Approved REACT_6900 IRAK, pelle IRAK1 interleukin-1 receptor-associated kinase 1; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1
3656 IRAK2 3656 HGNC:6113 Hs.449207 1553739_at
1553740_a_at
231779_at
interleukin-1 receptor-associated kinase 2 Interleukin-1 receptor-associated kinase 2 ENSG00000134070 ENSP00000256458 hsa+3656 IRAK2 IRAK2 3p25.2 Approved IRAK2 interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization
11213 IRAK3 11213 HGNC:17020 Hs.369265 interleukin-1 receptor-associated kinase 3 Interleukin-1 receptor-associated kinase 3 ENSG00000090376 ENSP00000261233 hsa+11213 IRAK3 IRAK3 12q13.13 Approved IRAK-M IRAK3 interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity)
51135 IRAK4 51135 HGNC:17967 Hs.138499 219618_at
interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase 4 ENSG00000198001 ENSP00000349096 hsa+51135 IRAK4 IRAK4 12q12 Approved NY-REN-64 IRAK4 interleukin-1 receptor-associated kinase 4; Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1
9020 MAP3K14 9020 HGNC:6853 Hs.404183 205192_at
mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 14 ENSG00000006062 ENSP00000342059 hsa+9020 MAP3K14 MAP3K14 17q21-q22 Approved NIK, HSNIK, FTDCR1B, HS HSNIK mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity)
4615 MYD88 4615 HGNC:7562 Hs.82116 209124_at
myeloid differentiation primary response gene (88) Myeloid differentiation primary response gene (88) ENSG00000172936 ENSP00000379625 hsa+4615 MYD88 MYD88 3p22 Approved MYD88 myeloid differentiation primary response gene (88); Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
4791 NFKB2 4791 HGNC:7795 Hs.73090 207535_s_at
209636_at
211524_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) ENSG00000077150 ENSP00000189444 hsa+4791 NFKB2 NFKB2 10q24 Approved LYT-10 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differ [...]
4792 NFKBIA 4792 HGNC:7797 Hs.81328 201502_s_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ENSG00000100906 ENSP00000216797 hsa+4792 NFKBIA NFKBI NFKBIA 14q13 Approved REACT_6900 IKBA, MAD-3, IkappaBalpha IKBA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
4803 NGF 4803 HGNC:7808 Hs.2561 206814_at
nerve growth factor (beta polypeptide) Nerve growth factor (beta polypeptide) ENSG00000134259 ENSP00000358525 hsa+4803 NGF NGFB NGF 1p13.1 Approved REACT_11061 NGFB nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons
4914 NTRK1 4914 HGNC:8031 Hs.406293 208605_s_at
neurotrophic tyrosine kinase, receptor, type 1 Neurotrophic tyrosine kinase, receptor, type 1 ENSG00000198400 ENSP00000351486 hsa+4914 NTRK1 NTRK1 1q21-q22 Approved REACT_11061 TRK, TRKA, MTC NTRK1 neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway
5290 PIK3CA 5290 HGNC:8975 Hs.553498 Hs.85701 204369_at
231854_at
235980_at
phosphoinositide-3-kinase, catalytic, alpha polypeptide Phosphoinositide-3-kinase, catalytic, alpha polypeptide ENSG00000121879 ENSP00000263967 hsa+5290 PIK3CA PIK3CA 3q26.3 Approved REACT_498 PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
5291 PIK3CB 5291 HGNC:8976 Hs.239818 212688_at
217620_s_at
phosphoinositide-3-kinase, catalytic, beta polypeptide Phosphoinositide-3-kinase, catalytic, beta polypeptide ENSG00000051382 ENSP00000289153 hsa+5291 PIK3CB PIK3C1 PIK3CB 3q21-qter Approved PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide; Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
5293 PIK3CD 5293 HGNC:8977 Hs.518451 203879_at
211230_s_at
phosphoinositide-3-kinase, catalytic, delta polypeptide Phosphoinositide-3-kinase, catalytic, delta polypeptide ENSG00000171608 ENSP00000366563 hsa+5293 PIK3CD PIK3CD 1p36.2 Approved p110D PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide
5294 PIK3CG 5294 HGNC:8978 Hs.32942 206369_s_at
206370_at
phosphoinositide-3-kinase, catalytic, gamma polypeptide Phosphoinositide-3-kinase, catalytic, gamma polypeptide ENSG00000105851 ENSP00000352121 hsa+5294 PIK3CG PIK3CG 7q22 Approved PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide; 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production
5295 PIK3R1 5295 HGNC:8979 Hs.132225 212239_at
212240_s_at
212249_at
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) ENSG00000145675 ENSP00000274335 hsa+5295 PIK3R1 PIK3R1 5q13.1 Approved REACT_498 GRB1, p85-ALPHA, p85 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues
5296 PIK3R2 5296 HGNC:8980 Hs.371344 1568629_s_at
207105_s_at
229392_s_at
phosphoinositide-3-kinase, regulatory subunit 2 (beta) Phosphoinositide-3-kinase, regulatory subunit 2 (beta) ENSG00000105647 ENSP00000222254 hsa+5296 PIK3R2 PIK3R2 19q13.2-q13.4 Approved P85B, p85 PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane
8503 PIK3R3 8503 HGNC:8981 Hs.655387 202743_at
211580_s_at
phosphoinositide-3-kinase, regulatory subunit 3 (gamma) Phosphoinositide-3-kinase, regulatory subunit 3 (gamma) ENSG00000117461 ENSP00000262741 hsa+8503 PIK3R3 PIK3R3 1p34.1 Approved p55 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma); Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1
23533 PIK3R5 23533 HGNC:30035 Hs.278901 220566_at
227553_at
227645_at
phosphoinositide-3-kinase, regulatory subunit 5 Phosphoinositide-3-kinase, regulatory subunit 5 ENSG00000141506 ENSP00000269300 hsa+23533 PIK3R5 PIK3R5 17p13.1 Approved P101-PI3K, p101 PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5; Regulatory subunit of the PI3K gamma complex
5530 PPP3CA 5530 HGNC:9314 Hs.435512 202425_x_at
202429_s_at
202457_s_at
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform ENSG00000138814 ENSP00000378323 hsa+5530 PPP3CA CALN, CALNA PPP3CA 4q24 Approved CNA1, CCN1, PPP2B CALN protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1
5532 PPP3CB 5532 HGNC:9315 Hs.500067 202432_at
209817_at
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform ENSG00000107758 ENSP00000378306 hsa+5532 PPP3CB CALNB PPP3CB 10q22.2 Approved PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin
5533 PPP3CC 5533 HGNC:9316 Hs.655661 207000_s_at
32541_at
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform GO:0008633 ENSG00000120910 ENSP00000240139 hsa+5533 PPP3CC PPP3CC EXP 8p21.3 Approved REACT_578 CALNA3 PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin
5534 PPP3R1 5534 HGNC:9317 Hs.280604 204506_at
204507_s_at
235071_at
protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform Protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform GO:0008633 ENSG00000115953 ENSP00000234310 hsa+5534 PPP3R1 PPP3R1 EXP 2p14 Approved REACT_578 CALNB1, CNB, CNB1 CNB protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity
5535 PPP3R2 5535 HGNC:9318 Hs.151167 231304_at
244782_at
protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform Protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform ENSG00000188386 ENSP00000363939 hsa+5535 PPP3R2 PPP3R2 9q31 Approved PPP3RL PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)
5566 PRKACA 5566 HGNC:9380 Hs.631630 202801_at
216234_s_at
protein kinase, cAMP-dependent, catalytic, alpha Protein kinase, cAMP-dependent, catalytic, alpha ENSG00000072062 ENSP00000309591 hsa+5566 PRKACA PRKACA 19p13.1 Approved REACT_1505 REACT_602 PKACa PRKACA protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus
5567 PRKACB 5567 HGNC:9381 Hs.487325 202741_at
202742_s_at
235780_at
protein kinase, cAMP-dependent, catalytic, beta Protein kinase, cAMP-dependent, catalytic, beta ENSG00000142875 ENSP00000359719 hsa+5567 PRKACB PRKACB 1p36.1 Approved PKACb PRKACB protein kinase, cAMP-dependent, catalytic, beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux
5568 PRKACG 5568 HGNC:9382 Hs.158029 207228_at
protein kinase, cAMP-dependent, catalytic, gamma Protein kinase, cAMP-dependent, catalytic, gamma ENSG00000165059 ENSP00000366488 hsa+5568 PRKACG PRKACG 9q13 Approved PKACg PRKACG protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus
5573 PRKAR1A 5573 HGNC:9388 Hs.280342 200603_at
200604_s_at
200605_s_at
242482_at
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) ENSG00000108946 ENSP00000351410 hsa+5573 PRKAR1A PRKAR1, TSE1 PRKAR1A 17q23-q24 Approved TSE1 protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
5575 PRKAR1B 5575 HGNC:9390 Hs.520851 212555_at
212559_at
protein kinase, cAMP-dependent, regulatory, type I, beta Protein kinase, cAMP-dependent, regulatory, type I, beta ENSG00000188191 ENSP00000353415 hsa+5575 PRKAR1B PRKAR1B 7pter-p22 Approved PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
5576 PRKAR2A 5576 HGNC:9391 Hs.631923 204842_x_at
204843_s_at
213052_at
225000_at
225011_at
protein kinase, cAMP-dependent, regulatory, type II, alpha Protein kinase, cAMP-dependent, regulatory, type II, alpha ENSG00000114302 ENSP00000265563 hsa+5576 PRKAR2A PRKAR2 PRKAR2A 3p21.3-p21.2 Approved PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha; Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
5577 PRKAR2B 5577 HGNC:9392 Hs.433068 203680_at
protein kinase, cAMP-dependent, regulatory, type II, beta Protein kinase, cAMP-dependent, regulatory, type II, beta ENSG00000005249 ENSP00000265717 hsa+5577 PRKAR2B PRKAR2 PRKAR2B 7q22.3 Approved PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta; Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
8797 TNFRSF10A 8797 HGNC:11904 Hs.591834 1552648_a_at
231775_at
241371_at
tumor necrosis factor receptor superfamily, member 10a Tumor necrosis factor receptor superfamily, member 10a ENSG00000104689 ENSP00000221132 hsa+8797 TNFRSF10A TNFRSF10A 8p21 Approved DR4, Apo2, TRAILR-1, CD261 TNFRSF10A tumor necrosis factor receptor superfamily, member 10a; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B
8795 TNFRSF10B 8795 HGNC:11905 Hs.521456 209294_x_at
209295_at
210405_x_at
tumor necrosis factor receptor superfamily, member 10b Tumor necrosis factor receptor superfamily, member 10b GO:0008633 ENSG00000120889 ENSP00000276431 hsa+8795 TNFRSF10B TNFRSF10B EXP 8p22-p21 Approved REACT_578 DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B
8794 TNFRSF10C 8794 HGNC:11906 Hs.655801 206222_at
210484_s_at
211163_s_at
234195_at
234644_x_at
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain ENSG00000173535 ENSP00000310908 hsa+8794 TNFRSF10C TNFRSF10C 8p22-p21 Approved DcR1, TRAILR3, LIT, TRID, CD263 TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand
8793 TNFRSF10D 8793 HGNC:11907 Hs.213467 210654_at
227345_at
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain ENSG00000173530 ENSP00000310263 hsa+8793 TNFRSF10D TNFRSF10D 8p21 Approved DcR2, TRUNDD, TRAILR4, CD264 TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway (According to PubMed:9382840 it cannot but according to PubMed:9430226 it can induce the NF-kappa-B pathway)
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
8743 TNFSF10 8743 HGNC:11925 Hs.478275 tumor necrosis factor (ligand) superfamily, member 10 Tumor necrosis factor (ligand) superfamily, member 10 GO:0008633 ENSG00000121858 ENSP00000241261 hsa+8743 TNFSF10 TNFSF10 EXP 3q26 Approved REACT_578 TRAIL, Apo-2L, TL2, CD253 TL2 tumor necrosis factor (ligand) superfamily, member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
8717 TRADD 8717 HGNC:12030 Hs.460996 1729_at
205641_s_at
213443_at
TNFRSF1A-associated via death domain TNFRSF1A-associated via death domain GO:0008633 ENSG00000102871 ENSP00000341268 hsa+8717 TRADD TRADD EXP 16q22 Approved REACT_578 Hs.89862 TRADD TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B
7186 TRAF2 7186 HGNC:12032 Hs.522506 204413_at
TNF receptor-associated factor 2 TNF receptor-associated factor 2 GO:0008633 ENSG00000127191 ENSP00000247668 hsa+7186 TRAF2 TRAF2 EXP 9q34 Approved REACT_578 TRAP3 ENSG00000127191 TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling
331 XIAP 331 HGNC:592 Hs.356076 206536_s_at
206537_at
225858_s_at
225859_at
228363_at
235222_x_at
243026_x_at
X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis ENSG00000101966 ENSP00000347858 hsa+331 XIAP API3, BIRC4 XIAP Xq25 Approved REACT_578 hILP BIRC4 X-linked inhibitor of apoptosis; Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B
83 genes found.

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