NAME: G1/S checkpoint

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
25 ABL1 25 HGNC:76 Hs.431048 202123_s_at
c-abl oncogene 1, receptor tyrosine kinase C-abl oncogene 1, receptor tyrosine kinase ENSG00000097007 ENSP00000361423 hsa+25 ABL1 ABL ABL1 9q34.1 Approved JTK7, c-ABL, p150 ABL1 c-abl oncogene 1, receptor tyrosine kinase; Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
8900 CCNA1 8900 HGNC:1577 Hs.417050 205899_at
cyclin A1 Cyclin A1 ENSG00000133101 ENSP00000255465 hsa+8900 CCNA1 CCNA1 13q12.3-q13 Approved CCNA1 cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells
898 CCNE1 898 HGNC:1589 Hs.244723 213523_at
242105_at
cyclin E1 Cyclin E1 ENSG00000105173 ENSP00000262643 hsa+898 CCNE1 CCNE CCNE1 19q12 Approved CCNE cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition
983 CDC2 983 HGNC:1722 Hs.334562 203213_at
203214_x_at
210559_s_at
231534_at
cell division cycle 2, G1 to S and G2 to M Cell division cycle 2, G1 to S and G2 to M GO:0006916 ENSG00000170312 ENSP00000362917 hsa+983 CDC2 CDC2 IDA 10q21.2 Approved REACT_152 REACT_1538 REACT_6850 CDC28A ENSG00000170312 cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1027 CDKN1B 1027 HGNC:1785 Hs.238990 209112_at
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cyclin-dependent kinase inhibitor 1B (p27, Kip1) GO:0006917 ENSG00000111276 ENSP00000228872 hsa+1027 CDKN1B CDKN1B IDA 12p13.1-p12 Approved KIP1, P27KIP1 KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events
1029 CDKN2A 1029 HGNC:1787 Hs.512599 207039_at
209644_x_at
211156_at
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GO:0006309 GO:0006917 GO:0006919 GO:0008637 ENSG00000147889 ENSP00000355153 hsa+1029 CDKN2A CDKN2, MLM CDKN2A IDA IMP 9p21 Approved CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]
1030 CDKN2B 1030 HGNC:1788 Hs.72901 207530_s_at
236313_at
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) ENSG00000147883 ENSP00000276925 hsa+1030 CDKN2B CDKN2B 9p21 Approved P15, MTS2, INK4B, TP15, CDK4I, p15INK4b CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein
1719 DHFR 1719 HGNC:2861 Hs.592364 Hs.648635 202532_s_at
202533_s_at
202534_x_at
48808_at
dihydrofolate reductase Dihydrofolate reductase ENSG00000188985 ENSP00000396308 DHFR DHFR 5q11.2-q13.2 Approved DHFR dihydrofolate reductase
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
2932 GSK3B 2932 HGNC:4617 Hs.445733 209945_s_at
226183_at
226191_at
240562_at
242336_at
glycogen synthase kinase 3 beta Glycogen synthase kinase 3 beta GO:0043066 ENSG00000082701 ENSP00000324806 hsa+2932 GSK3B GSK3B IDA 3q13.3 Approved REACT_11045 GSK3B glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin
3065 HDAC1 3065 HGNC:4852 Hs.88556 201209_at
histone deacetylase 1 Histone deacetylase 1 ENSG00000116478 ENSP00000362649 hsa+3065 HDAC1 RPD3L1 HDAC1 1p34 Approved HD1, GON-10 HDAC1 histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function
5925 RB1 5925 HGNC:9884 Hs.408528 203132_at
211540_s_at
retinoblastoma 1 Retinoblastoma 1 ENSG00000139687 ENSP00000267163 hsa+5925 RB1 OSRC RB1 13q14.2 Approved REACT_152 REACT_383 RB1 retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repres [...]
6502 SKP2 6502 HGNC:10901 Hs.23348 203625_x_at
203626_s_at
210567_s_at
S-phase kinase-associated protein 2 (p45) S-phase kinase-associated protein 2 (p45) ENSG00000145604 ENSP00000274255 hsa+6502 SKP2 SKP2 5p13 Approved FBXL1, FBL1 SKP2 S-phase kinase-associated protein 2 (p45); Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of [...]
7027 TFDP1 7027 HGNC:11749 Hs.79353 204147_s_at
212330_at
242538_at
242939_at
transcription factor Dp-1 Transcription factor Dp-1 ENSG00000198176 ENSP00000364519 hsa+7027 TFDP1 TFDP1 13q34 Approved Dp-1, DRTF1, DP1 TFDP1 transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis
7040 TGFB1 7040 HGNC:11766 Hs.645227 203084_at
203085_s_at
transforming growth factor, beta 1 Transforming growth factor, beta 1 GO:0006917 ENSG00000105329 ENSP00000221930 hsa+7040 TGFB1 TGFB, DPD1 TGFB1 IDA 19q13.1 Approved REACT_604 REACT_6167 REACT_6844 CED, TGFbeta CED transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
21 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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