NAME: Induction of apoptosis through dr3 and dr4/5 death receptors

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
58 ACTA1 58 HGNC:129 Hs.1288 203872_at
actin, alpha 1, skeletal muscle Actin, alpha 1, skeletal muscle ENSG00000143632 ENSP00000355645 ACTA1 ACTA ACTA1 1q42.13 Approved ACTA1 actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (By similarity)
317 APAF1 317 HGNC:576 Hs.708112 204859_s_at
211553_x_at
211554_s_at
apoptotic peptidase activating factor 1 Apoptotic peptidase activating factor 1 GO:0008635 ENSG00000120868 ENSP00000353059 hsa+317 APAF1 APAF1 IDA 12q23 Approved REACT_578 CED4, APAF-1 CED4 apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis
351 APP 351 HGNC:620 Hs.434980 200602_at
211277_x_at
214953_s_at
amyloid beta (A4) precursor protein Amyloid beta (A4) precursor protein ENSG00000142192 ENSP00000284981 APP AD1 APP 21q21.2 Approved REACT_604 APP amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6)
397 ARHGDIB 397 HGNC:679 Hs.504877 1555811_at
1555812_a_at
201288_at
Rho GDP dissociation inhibitor (GDI) beta Rho GDP dissociation inhibitor (GDI) beta ENSG00000111348 ENSP00000228945 ARHGDIB RAP1GN1, GDIA2, GDID4 ARHGDIB 12p12.3 Approved REACT_11044 Ly-GDI, RhoGDI2 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them
581 BAX 581 HGNC:959 Hs.631546 208478_s_at
211833_s_at
BCL2-associated X protein BCL2-associated X protein GO:0006917 GO:0006919 GO:0043525 ENSG00000087088 ENSP00000293288 hsa+581 BAX BAX IDA 19q13.3-q13.4 Approved REACT_578 BCL2L4 BAX BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
637 BID 637 HGNC:1050 Hs.591054 BH3 interacting domain death agonist BH3 interacting domain death agonist GO:0001836 GO:0008633 ENSG00000015475 ENSP00000318822 hsa+637 BID BID EXP IDA 22q11.2 Approved REACT_578 BID BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
330 BIRC3 330 HGNC:591 Hs.127799 210538_s_at
baculoviral IAP repeat-containing 3 Baculoviral IAP repeat-containing 3 ENSG00000023445 ENSP00000263464 hsa+330 BIRC3 API2 BIRC3 11q22 Approved cIAP2, hiap-1, MIHC, RNF49, MALT2 API2 baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
834 CASP1 834 HGNC:1499 Hs.2490 1552703_s_at
206011_at
209970_x_at
211366_x_at
211367_s_at
211368_s_at
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) ENSG00000137752 ENSP00000410076 CASP1 IL1BC CASP1 11q23 Approved ICE CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. A [...]
843 CASP10 843 HGNC:1500 Hs.5353 205467_at
210708_x_at
210955_at
211888_x_at
caspase 10, apoptosis-related cysteine peptidase Caspase 10, apoptosis-related cysteine peptidase GO:0008624 ENSG00000003400 ENSP00000286186 hsa+843 CASP10 CASP10 EXP 2q33-q34 Approved REACT_578 MCH4 CASP10 caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
835 CASP2 835 HGNC:1503 Hs.368982 208050_s_at
209811_at
209812_x_at
211140_s_at
226032_at
226036_x_at
34449_at
caspase 2, apoptosis-related cysteine peptidase Caspase 2, apoptosis-related cysteine peptidase ENSG00000106144 ENSP00000312664 CASP2 NEDD2 CASP2 7q34-q35 Approved ICH1 CASP2 caspase 2, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
837 CASP4 837 HGNC:1505 Hs.138378 209310_s_at
213596_at
caspase 4, apoptosis-related cysteine peptidase Caspase 4, apoptosis-related cysteine peptidase ENSG00000196954 ENSP00000388566 CASP4 CASP4 11q22.2-q22.3 Approved ICE(rel)II, ICH-2, TX CASP4 caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1
839 CASP6 839 HGNC:1507 Hs.654616 209790_s_at
211464_x_at
caspase 6, apoptosis-related cysteine peptidase Caspase 6, apoptosis-related cysteine peptidase ENSG00000138794 ENSP00000265164 hsa+839 CASP6 CASP6 4q25 Approved MCH2 CASP6 caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
842 CASP9 842 HGNC:1511 Hs.329502 203984_s_at
210775_x_at
240437_at
caspase 9, apoptosis-related cysteine peptidase Caspase 9, apoptosis-related cysteine peptidase ENSG00000132906 ENSP00000330237 hsa+842 CASP9 CASP9 1p36.21 Approved REACT_578 MCH6, ICE-LAP6, APAF-3 CASP9 caspase 9, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
1073 CFL2 1073 HGNC:1875 Hs.180141 224352_s_at
224663_s_at
233496_s_at
cofilin 2 (muscle) Cofilin 2 (muscle) ENSG00000165410 ENSP00000298159 CFL2 CFL2 14q13.2 Approved CFL2 cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity)
8738 CRADD 8738 HGNC:2340 Hs.591016 209833_at
CASP2 and RIPK1 domain containing adaptor with death domain CASP2 and RIPK1 domain containing adaptor with death domain ENSG00000169372 ENSP00000327647 CRADD CRADD 12q21.33-q23.1 Approved RAIDD RAIDD CASP2 and RIPK1 domain containing adaptor with death domain; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruites caspase-2 to the TNFR-1 signalling complex
54205 CYCS 54205 HGNC:19986 Hs.437060 Hs.617193 cytochrome c, somatic Cytochrome c, somatic GO:0006309 GO:0006915 ENSG00000172115 ENSP00000307786 hsa+54205 CYCS CYCS IDA IMP 7p21.2 Approved REACT_578 REACT_6305 HCS CYCS cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
1676 DFFA 1676 HGNC:2772 Hs.484782 203277_at
223518_at
226116_at
DNA fragmentation factor, 45kDa, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide GO:0006309 GO:0043066 ENSG00000160049 ENSP00000366237 hsa+1676 DFFA DFFA IDA 1p36.3-p36.2 Approved DFF-45, DFF45, ICAD, DFF1 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40)
1677 DFFB 1677 HGNC:2773 Hs.133089 206752_s_at
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) GO:0006309 GO:0030263 ENSG00000169598 ENSP00000367454 hsa+1677 DFFB DFFB IDA 1p36.3 Approved CAD, CPAN, DFF-40, DFF40 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
56616 DIABLO 56616 HGNC:21528 Hs.169611 219350_s_at
diablo homolog (Drosophila) Diablo homolog (Drosophila) ENSG00000184047 ENSP00000267169 DIABLO DIABLO 12q24.31 Approved REACT_578 SMAC, DIABLO-S, FLJ25049, FLJ10537 DIABLO diablo homolog (Drosophila); Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP)
2620 GAS2 2620 HGNC:4167 Hs.632151 205848_at
growth arrest-specific 2 Growth arrest-specific 2 ENSG00000148935 ENSP00000278187 GAS2 GAS2 11p14.3 Approved GAS2 growth arrest-specific 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)
2934 GSN 2934 HGNC:4620 Hs.522373 200696_s_at
214040_s_at
227957_at
227958_s_at
gelsolin (amyloidosis, Finnish type) Gelsolin (amyloidosis, Finnish type) ENSG00000148180 ENSP00000362924 GSN GSN 9q33 Approved DKFZp313L0718 GSN gelsolin (amyloidosis, Finnish type); Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed
3002 GZMB 3002 HGNC:4709 Hs.1051 210164_at
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) GO:0006922 ENSG00000100453 ENSP00000216341 GZMB CTLA1, CSPB GZMB IDA 14q11.2 Approved REACT_578 CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT CSPB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
3875 KRT18 3875 HGNC:6430 Hs.406013 201596_x_at
keratin 18 Keratin 18 GO:0043066 ENSG00000111057 ENSP00000373487 KRT18 KRT18 IDA 12q13 Approved KRT18 keratin 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection
3984 LIMK1 3984 HGNC:6613 Hs.647035 204356_at
204357_s_at
208372_s_at
LIM domain kinase 1 LIM domain kinase 1 ENSG00000106683 ENSP00000336740 LIMK1 LIMK1 7q11.23 Approved LIMK LIMK1 LIM domain kinase 1; Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development
4000 LMNA 4000 HGNC:6636 Hs.594444 1554600_s_at
203411_s_at
212086_x_at
212089_at
214213_x_at
lamin A/C Lamin A/C ENSG00000160789 ENSP00000357283 LMNA LMN1, CMD1A, LGMD1B LMNA 1q22 Approved LMNA lamin A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals
4001 LMNB1 4001 HGNC:6637 Hs.89497 203276_at
lamin B1 Lamin B1 ENSG00000113368 ENSP00000261366 LMNB1 LMNB1 5q23.2 Approved LMNB1 lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin
84823 LMNB2 84823 HGNC:6638 Hs.538286 216952_s_at
lamin B2 Lamin B2 ENSG00000176619 ENSP00000327054 LMNB2 LMN2 LMNB2 19p13.3 Approved LMNB2 lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin
55367 LRDD 55367 HGNC:16491 Hs.592290 leucine-rich repeats and death domain containing Leucine-rich repeats and death domain containing ENSG00000177595 ENSP00000337797 LRDD LRDD 11p15.5 Approved PIDD, MGC16925, DKFZp434D229 PIDD leucine-rich repeats and death domain containing; Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways
8567 MADD 8567 HGNC:6766 Hs.82548 210252_s_at
38398_at
MAP-kinase activating death domain MAP-kinase activating death domain GO:0042981 ENSG00000110514 ENSP00000310933 MADD MADD IMP 11p11.2 Approved DENN, KIAA0358, RAB3GEP MADD MAP-kinase activating death domain; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant a [...]
4214 MAP3K1 4214 HGNC:6848 Hs.657756 214786_at
225927_at
mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 ENSG00000095015 ENSP00000382423 MAP3K1 MEKK1 MAP3K1 5q11.2 Approved REACT_6900 MEKK, MAPKKK1 MEKK mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway
4926 NUMA1 4926 HGNC:8059 Hs.325978 nuclear mitotic apparatus protein 1 Nuclear mitotic apparatus protein 1 ENSG00000137497 ENSP00000352675 NUMA1 NUMA1 11q13 Approved NUMA1 nuclear mitotic apparatus protein 1; May be a structural component of the nucleus
142 PARP1 142 HGNC:270 Hs.177766 208644_at
poly (ADP-ribose) polymerase 1 Poly (ADP-ribose) polymerase 1 ENSG00000143799 ENSP00000355759 hsa+142 PARP1 PPOL, ADPRT PARP1 1q41-q42 Approved PARP PARP1 poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150
5551 PRF1 5551 HGNC:9360 Hs.2200 1553681_a_at
214617_at
perforin 1 (pore forming protein) Perforin 1 (pore forming protein) ENSG00000180644 ENSP00000316746 PRF1 PRF1 10q22 Approved PFP, P1, HPLH2 PRF1 perforin 1 (pore forming protein); In the presence of calcium, binds to target cell membranes. Inserts into target cell membranes and forms pores, and so contributes to cytolysis and apoptosis of target cells
5747 PTK2 5747 HGNC:9611 Hs.395482 1559529_at
207821_s_at
208820_at
241453_at
PTK2 protein tyrosine kinase 2 PTK2 protein tyrosine kinase 2 ENSG00000169398 ENSP00000341189 PTK2 PTK2 8q24.3 Approved FAK, FADK, FAK1 FAK PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
6304 SATB1 6304 HGNC:10541 Hs.517717 203408_s_at
241365_at
SATB homeobox 1 SATB homeobox 1 ENSG00000182568 ENSP00000341024 SATB1 SATB1 3p24.3 Approved SATB1 SATB homeobox 1; Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a [...]
9748 SLK 9748 HGNC:11088 Hs.591922 206874_s_at
206875_s_at
STE20-like kinase (yeast) STE20-like kinase (yeast) ENSG00000065613 ENSP00000358770 SLK SLK 10q25.1 Approved STK2, se20-9, KIAA0204 SLK STE20-like kinase (yeast); Mediates apoptosis and actin stress fiber dissolution (By similarity)
6709 SPTAN1 6709 HGNC:11273 Hs.372331 208611_s_at
214925_s_at
214926_at
215235_at
241150_at
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ENSG00000197694 ENSP00000361824 SPTAN1 SPTAN1 9q34.11 Approved SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
6720 SREBF1 6720 HGNC:11289 Hs.592123 1558875_at
202308_at
sterol regulatory element binding transcription factor 1 Sterol regulatory element binding transcription factor 1 ENSG00000072310 ENSP00000348069 SREBF1 SREBF1 17p11.2 Approved SREBP1, bHLHd1, SREBP-1c SREBF1 sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3')
7020 TFAP2A 7020 HGNC:11742 Hs.519880 204653_at
204654_s_at
210669_at
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) ENSG00000137203 ENSP00000368924 TFAP2A TFAP2, AP2TF TFAP2A 6pter-p22.3 Approved AP-2 TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis [...]
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
7150 TOP1 7150 HGNC:11986 Hs.472737 208900_s_at
208901_s_at
topoisomerase (DNA) I Topoisomerase (DNA) I ENSG00000198900 ENSP00000354522 TOP1 TOP1 20q12-q13.1 Approved TOP1 topoisomerase (DNA) I; The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another
8717 TRADD 8717 HGNC:12030 Hs.460996 1729_at
205641_s_at
213443_at
TNFRSF1A-associated via death domain TNFRSF1A-associated via death domain GO:0008633 ENSG00000102871 ENSP00000341268 hsa+8717 TRADD TRADD EXP 16q22 Approved REACT_578 Hs.89862 TRADD TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B
7186 TRAF2 7186 HGNC:12032 Hs.522506 204413_at
TNF receptor-associated factor 2 TNF receptor-associated factor 2 GO:0008633 ENSG00000127191 ENSP00000247668 hsa+7186 TRAF2 TRAF2 EXP 9q34 Approved REACT_578 TRAP3 ENSG00000127191 TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling
7431 VIM 7431 HGNC:12692 Hs.642813 1555938_x_at
201426_s_at
vimentin Vimentin ENSG00000026025 ENSP00000224237 VIM VIM 10p13 Approved VIM vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells
331 XIAP 331 HGNC:592 Hs.356076 206536_s_at
206537_at
225858_s_at
225859_at
228363_at
235222_x_at
243026_x_at
X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis ENSG00000101966 ENSP00000347858 hsa+331 XIAP API3, BIRC4 XIAP Xq25 Approved REACT_578 hILP BIRC4 X-linked inhibitor of apoptosis; Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B
52 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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