NAME: Apoptosis - Homo sapiens (human)

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
317 APAF1 317 HGNC:576 Hs.708112 204859_s_at
211553_x_at
211554_s_at
apoptotic peptidase activating factor 1 Apoptotic peptidase activating factor 1 GO:0008635 ENSG00000120868 ENSP00000353059 hsa+317 APAF1 APAF1 IDA 12q23 Approved REACT_578 CED4, APAF-1 CED4 apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis
572 BAD 572 HGNC:936 Hs.370254 1861_at
209364_at
232660_at
BCL2-associated agonist of cell death BCL2-associated agonist of cell death GO:0008633 ENSG00000002330 ENSP00000309103 hsa+572 BAD BAD EXP 11q13.1 Approved REACT_578 BCL2L8, BBC2 BAD BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
578 BAK1 578 HGNC:949 Hs.485139 203728_at
BCL2-antagonist/killer 1 BCL2-antagonist/killer 1 GO:0001836 ENSG00000030110 ENSP00000363591 BAK1 CDN1 BAK1 IDA 6p21.31 Approved REACT_578 BCL2L7, BAK BAK1 BCL2-antagonist/killer 1; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis
581 BAX 581 HGNC:959 Hs.631546 208478_s_at
211833_s_at
BCL2-associated X protein BCL2-associated X protein GO:0006917 GO:0006919 GO:0043525 ENSG00000087088 ENSP00000293288 hsa+581 BAX BAX IDA 19q13.3-q13.4 Approved REACT_578 BCL2L4 BAX BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis
27113 BBC3 27113 HGNC:17868 Hs.467020 211692_s_at
BCL2 binding component 3 BCL2 binding component 3 GO:0001836 GO:0006915 GO:0006917 GO:0006919 ENSG00000105327 ENSP00000404503 BBC3 BBC3 IDA 19q13.3-q13.4 Approved REACT_578 JFY1, PUMA BBC3 BCL2 binding component 3; Essential mediator of p53-dependent and p53-independent apoptosis
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
598 BCL2L1 598 HGNC:992 Hs.516966 206665_s_at
212312_at
215037_s_at
231228_at
BCL2-like 1 BCL2-like 1 GO:0001836 ENSG00000171552 ENSP00000302564 hsa+598 BCL2L1 BCL2L1 IDA 20q11.21 Approved REACT_578 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS BCL2L1 BCL2-like 1; Potent inhibitor of cell death. Isoform Bcl-X(L) anti- apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis
10018 BCL2L11 10018 HGNC:994 Hs.469658 1553088_a_at
1553096_s_at
1555372_at
1558143_a_at
208536_s_at
222343_at
225606_at
BCL2-like 11 (apoptosis facilitator) BCL2-like 11 (apoptosis facilitator) GO:0008633 ENSG00000153094 ENSP00000350311 BCL2L11 BCL2L11 EXP 2q13 Approved REACT_578 BOD, BimL, BimEL, BIM BOD BCL2-like 11 (apoptosis facilitator); Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis
637 BID 637 HGNC:1050 Hs.591054 BH3 interacting domain death agonist BH3 interacting domain death agonist GO:0001836 GO:0008633 ENSG00000015475 ENSP00000318822 hsa+637 BID BID EXP IDA 22q11.2 Approved REACT_578 BID BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
90427 BMF 90427 HGNC:24132 Hs.591104 226530_at
Bcl2 modifying factor Bcl2 modifying factor ENSG00000104081 ENSP00000346697 BMF BMF 15q14 Approved FLJ00065 BMF Bcl2 modifying factor; May play a role in apoptosis. Isoform 1 seems to be the main initiator
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
842 CASP9 842 HGNC:1511 Hs.329502 203984_s_at
210775_x_at
240437_at
caspase 9, apoptosis-related cysteine peptidase Caspase 9, apoptosis-related cysteine peptidase ENSG00000132906 ENSP00000330237 hsa+842 CASP9 CASP9 1p36.21 Approved REACT_578 MCH6, ICE-LAP6, APAF-3 CASP9 caspase 9, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
54205 CYCS 54205 HGNC:19986 Hs.437060 Hs.617193 cytochrome c, somatic Cytochrome c, somatic GO:0006309 GO:0006915 ENSG00000172115 ENSP00000307786 hsa+54205 CYCS CYCS IDA IMP 7p21.2 Approved REACT_578 REACT_6305 HCS CYCS cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
56616 DIABLO 56616 HGNC:21528 Hs.169611 219350_s_at
diablo homolog (Drosophila) Diablo homolog (Drosophila) ENSG00000184047 ENSP00000267169 DIABLO DIABLO 12q24.31 Approved REACT_578 SMAC, DIABLO-S, FLJ25049, FLJ10537 DIABLO diablo homolog (Drosophila); Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP)
8655 DYNLL1 8655 HGNC:15476 Hs.5120 200703_at
dynein, light chain, LC8-type 1 Dynein, light chain, LC8-type 1 GO:0008633 ENSG00000088986 ENSP00000242577 DYNLL1 DNCL1 DYNLL1 EXP 12q24.23 Approved REACT_578 hdlc1, DLC1, PIN, LC8, DLC8 DYNLL1 dynein, light chain, LC8-type 1; May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)
140735 DYNLL2 140735 HGNC:24596 Hs.591176 229106_at
dynein, light chain, LC8-type 2 Dynein, light chain, LC8-type 2 ENSG00000121083 ENSP00000240343 DYNLL2 DYNLL2 17q23.2 Approved MGC17810, Dlc2, DNCL1B DYNLL2 dynein, light chain, LC8-type 2; May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
3002 GZMB 3002 HGNC:4709 Hs.1051 210164_at
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) GO:0006922 ENSG00000100453 ENSP00000216341 GZMB CTLA1, CSPB GZMB IDA 14q11.2 Approved REACT_578 CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT CSPB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
5599 MAPK8 5599 HGNC:6881 Hs.138211 210477_x_at
210671_x_at
226046_at
226048_at
229664_at
mitogen-activated protein kinase 8 Mitogen-activated protein kinase 8 GO:0008633 GO:0043066 ENSG00000107643 ENSP00000353483 MAPK8 PRKM8 MAPK8 EXP IDA 10q11 Approved REACT_578 REACT_6900 JNK, JNK1, SAPK1 MAPK8 mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4)
4836 NMT1 4836 HGNC:7857 Hs.532790 201157_s_at
201158_at
201159_s_at
N-myristoyltransferase 1 N-myristoyltransferase 1 ENSG00000136448 ENSP00000258960 NMT1 NMT1 17q21 Approved NMT NMT N-myristoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity)
5366 PMAIP1 5366 HGNC:9108 Hs.96 204285_s_at
204286_s_at
phorbol-12-myristate-13-acetate-induced protein 1 Phorbol-12-myristate-13-acetate-induced protein 1 GO:0001836 GO:0006917 GO:0006919 GO:0006921 GO:0006926 ENSG00000141682 ENSP00000326119 PMAIP1 PMAIP1 IDA 18q21.32 Approved REACT_578 APR, NOXA PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1
5533 PPP3CC 5533 HGNC:9316 Hs.655661 207000_s_at
32541_at
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform GO:0008633 ENSG00000120910 ENSP00000240139 hsa+5533 PPP3CC PPP3CC EXP 8p21.3 Approved REACT_578 CALNA3 PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin
5534 PPP3R1 5534 HGNC:9317 Hs.280604 204506_at
204507_s_at
235071_at
protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform Protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform GO:0008633 ENSG00000115953 ENSP00000234310 hsa+5534 PPP3R1 PPP3R1 EXP 2p14 Approved REACT_578 CALNB1, CNB, CNB1 CNB protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity
7027 TFDP1 7027 HGNC:11749 Hs.79353 204147_s_at
212330_at
242538_at
242939_at
transcription factor Dp-1 Transcription factor Dp-1 ENSG00000198176 ENSP00000364519 hsa+7027 TFDP1 TFDP1 13q34 Approved Dp-1, DRTF1, DP1 TFDP1 transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis
331 XIAP 331 HGNC:592 Hs.356076 206536_s_at
206537_at
225858_s_at
225859_at
228363_at
235222_x_at
243026_x_at
X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis ENSG00000101966 ENSP00000347858 hsa+331 XIAP API3, BIRC4 XIAP Xq25 Approved REACT_578 hILP BIRC4 X-linked inhibitor of apoptosis; Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B
7529 YWHAB 7529 HGNC:12849 Hs.643544 208743_s_at
217717_s_at
217718_s_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide GO:0008633 ENSG00000166913 ENSP00000300161 hsa+7529 YWHAB YWHAB EXP 20q13.1 Approved REACT_578 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis
29 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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