NAME: Intrinsic Pathway for Apoptosis

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
22985 ACIN1 22985 HGNC:17066 Hs.124490 201715_s_at
apoptotic chromatin condensation inducer 1 Apoptotic chromatin condensation inducer 1 GO:0030263 ENSG00000100813 ENSP00000262710 ACIN1 ACINUS ACIN1 IDA 14q11.2 Approved KIAA0670, fSAP152 ACIN1 apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3
118 ADD1 118 HGNC:243 Hs.183706 208030_s_at
214726_x_at
214736_s_at
238939_at
adducin 1 (alpha) Adducin 1 (alpha) ENSG00000087274 ENSP00000264758 ADD1 ADD1 4p16.3 Approved ADD1 adducin 1 (alpha); Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin
324 APC 324 HGNC:583 Hs.158932 203525_s_at
203526_s_at
203527_s_at
215310_at
216933_x_at
adenomatous polyposis coli Adenomatous polyposis coli ENSG00000134982 ENSP00000257430 APC APC 5q21-q22 Approved REACT_11045 DP2, DP3, DP2.5 DP2 adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state
10134 BCAP31 10134 HGNC:16695 Hs.522817 200837_at
B-cell receptor-associated protein 31 B-cell receptor-associated protein 31 ENSG00000185825 ENSP00000392330 BCAP31 BCAP31 Xq28 Approved DXS1357E, BAP31, 6C6-Ag, CDM BCAP31 B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
660 BMX 660 HGNC:1079 Hs.495731 206464_at
BMX non-receptor tyrosine kinase BMX non-receptor tyrosine kinase ENSG00000102010 ENSP00000308774 BMX BMX Xp22.2 Approved ETK, PSCTK3 BMX BMX non-receptor tyrosine kinase; Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells
836 CASP3 836 HGNC:1504 Hs.141125 202763_at
236729_at
caspase 3, apoptosis-related cysteine peptidase Caspase 3, apoptosis-related cysteine peptidase GO:0030264 GO:0043066 ENSG00000164305 ENSP00000311032 hsa+836 CASP3 CASP3 IGI IMP 4q34 Approved REACT_578 CPP32, CPP32B, Yama, apopain CASP3 caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
839 CASP6 839 HGNC:1507 Hs.654616 209790_s_at
211464_x_at
caspase 6, apoptosis-related cysteine peptidase Caspase 6, apoptosis-related cysteine peptidase ENSG00000138794 ENSP00000265164 hsa+839 CASP6 CASP6 4q25 Approved MCH2 CASP6 caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
840 CASP7 840 HGNC:1508 Hs.9216 207181_s_at
caspase 7, apoptosis-related cysteine peptidase Caspase 7, apoptosis-related cysteine peptidase ENSG00000165806 ENSP00000298700 hsa+840 CASP7 CASP7 10q25 Approved REACT_578 MCH3, CMH-1, ICE-LAP3 CASP7 caspase 7, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
999 CDH1 999 HGNC:1748 Hs.461086 201130_s_at
201131_s_at
cadherin 1, type 1, E-cadherin (epithelial) Cadherin 1, type 1, E-cadherin (epithelial) ENSG00000039068 ENSP00000261769 CDH1 UVO CDH1 16q22.1 Approved REACT_6900 uvomorulin, CD324 CDH1 cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7
63967 CLSPN 63967 HGNC:19715 1553120_at
219621_at
242150_at
243840_at
claspin ENSG00000092853 ENSP00000312995 CLSPN 1p34.3 Approved claspin homolog (Xenopus laevis); Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks
1499 CTNNB1 1499 HGNC:2514 Hs.476018 1554411_at
201533_at
223679_at
catenin (cadherin-associated protein), beta 1, 88kDa Catenin (cadherin-associated protein), beta 1, 88kDa ENSG00000168036 ENSP00000344456 CTNNB1 CTNNB CTNNB1 3p21 Approved REACT_11045 CTNNB catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway
28988 DBNL 28988 HGNC:2696 222429_at
drebrin-like ENSG00000136279 ENSP00000407950 DBNL 7p13 Approved SH3P7, HIP-55 drebrin-like; Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin
1676 DFFA 1676 HGNC:2772 Hs.484782 203277_at
223518_at
226116_at
DNA fragmentation factor, 45kDa, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide GO:0006309 GO:0043066 ENSG00000160049 ENSP00000366237 hsa+1676 DFFA DFFA IDA 1p36.3-p36.2 Approved DFF-45, DFF45, ICAD, DFF1 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40)
1677 DFFB 1677 HGNC:2773 Hs.133089 206752_s_at
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) GO:0006309 GO:0030263 ENSG00000169598 ENSP00000367454 hsa+1677 DFFB DFFB IDA 1p36.3 Approved CAD, CPAN, DFF-40, DFF40 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
10059 DNM1L 10059 HGNC:2973 Hs.556296 203105_s_at
226154_at
237797_at
dynamin 1-like Dynamin 1-like GO:0043653 ENSG00000087470 ENSP00000266481 DNM1L DNM1L IMP 12p11.21 Approved DRP1, DVLP, HDYNIV, DYMPLE, VPS1 DVLP dynamin 1-like; Functions in mitochondrial and peroxisomal division probably by regulating membrane fission. Enzyme hydrolyzing GTP that oligomerizes to form ring-like structures and is able to remodel membranes. May also play a role on organelles of the secretory pathway. Isoform 1 and isoform 2 inhibit peroxisomal division when overexpressed. Isoform 3 and isoform 4 have no effect on peroxisomal division when overexpressed
1828 DSG1 1828 HGNC:3048 Hs.2633 206642_at
desmoglein 1 Desmoglein 1 ENSG00000134760 ENSP00000257192 DSG1 DSG DSG1 18q12.1 Approved CDHF4 DSG1 desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion
1829 DSG2 1829 HGNC:3049 Hs.412597 1553105_s_at
217901_at
desmoglein 2 Desmoglein 2 ENSG00000046604 ENSP00000261590 DSG2 DSG2 18q12.1 Approved CDHF5 DSG2 desmoglein 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion
1830 DSG3 1830 HGNC:3050 Hs.1925 205595_at
235075_at
desmoglein 3 (pemphigus vulgaris antigen) Desmoglein 3 (pemphigus vulgaris antigen) ENSG00000134757 ENSP00000257189 DSG3 DSG3 18q12.1 Approved CDHF6 DSG3 desmoglein 3 (pemphigus vulgaris antigen); Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion
1832 DSP 1832 HGNC:3052 Hs.519873 200606_at
desmoplakin Desmoplakin ENSG00000096696 ENSP00000369129 DSP DSP 6pter-p21 Approved KPPS2, PPKS2, DPI, DPII DSP desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes
2339 FNTA 2339 HGNC:3782 Hs.370312 200090_at
209471_s_at
230808_at
farnesyltransferase, CAAX box, alpha Farnesyltransferase, CAAX box, alpha ENSG00000168522 ENSP00000303423 FNTA FNTA 8p11.21 Approved FPTA, PGGT1A, PTAR2 FPTA farnesyltransferase, CAAX box, alpha; Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate
2620 GAS2 2620 HGNC:4167 Hs.632151 205848_at
growth arrest-specific 2 Growth arrest-specific 2 ENSG00000148935 ENSP00000278187 GAS2 GAS2 11p14.3 Approved GAS2 growth arrest-specific 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)
2934 GSN 2934 HGNC:4620 Hs.522373 200696_s_at
214040_s_at
227957_at
227958_s_at
gelsolin (amyloidosis, Finnish type) Gelsolin (amyloidosis, Finnish type) ENSG00000148180 ENSP00000362924 GSN GSN 9q33 Approved DKFZp313L0718 GSN gelsolin (amyloidosis, Finnish type); Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed
3005 H1F0 3005 HGNC:4714 Hs.226117 208886_at
H1 histone family, member 0 H1 histone family, member 0 ENSG00000189060 ENSP00000344504 H1F0 H1FV H1F0 22q13.1 Approved H10 H1F0 H1 histone family, member 0; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division
3024 HIST1H1A 3024 HGNC:4715 Hs.150206 208484_at
histone cluster 1, H1a Histone cluster 1, H1a ENSG00000124610 ENSP00000244573 HIST1H1A H1F1 HIST1H1A 6p22.1 Approved H1.1 HIST1H1A histone cluster 1, H1a; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
3009 HIST1H1B 3009 HGNC:4719 Hs.131956 214534_at
histone cluster 1, H1b Histone cluster 1, H1b ENSG00000184357 ENSP00000330074 HIST1H1B H1F5 HIST1H1B 6p22.1 Approved H1.5 HIST1H1B histone cluster 1, H1b; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
3006 HIST1H1C 3006 HGNC:4716 Hs.7644 209398_at
histone cluster 1, H1c Histone cluster 1, H1c ENSG00000187837 ENSP00000339566 HIST1H1C H1F2 HIST1H1C 6p21.3 Approved H1.2 HIST1H1C histone cluster 1, H1c; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
3007 HIST1H1D 3007 HGNC:4717 Hs.136857 214537_at
histone cluster 1, H1d Histone cluster 1, H1d ENSG00000124575 ENSP00000244534 HIST1H1D H1F3 HIST1H1D 6p21.3 Approved H1.3 HIST1H1D histone cluster 1, H1d; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
3008 HIST1H1E 3008 HGNC:4718 Hs.248133 208553_at
histone cluster 1, H1e Histone cluster 1, H1e ENSG00000168298 ENSP00000307705 HIST1H1E H1F4 HIST1H1E 6p22.1 Approved H1.4 HIST1H1E histone cluster 1, H1e; Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
3146 HMGB1 3146 HGNC:4983 Hs.593339 Hs.644368 Hs.714718 200679_x_at
200680_x_at
214938_x_at
224731_at
224734_at
high-mobility group box 1 High-mobility group box 1 GO:0006288 ENSG00000189403 ENSP00000343040 hsa+3146 HMGB1 HMG1 HMGB1 IDA 13q12 Approved HMG3, SBP-1, DKFZp686A04236 HMGB1 high-mobility group box 1; Binds preferentially single-stranded DNA and unwinds double stranded DNA (By similarity)
3148 HMGB2 3148 HGNC:5000 Hs.434953 208808_s_at
236091_at
high-mobility group box 2 High-mobility group box 2 GO:0006288 ENSG00000164104 ENSP00000296503 HMGB2 HMG2 HMGB2 IDA 4q31 Approved HMG2 high-mobility group box 2; Binds preferentially single-stranded DNA and unwinds double stranded DNA
3836 KPNA1 3836 HGNC:6394 Hs.161008 202055_at
202056_at
202057_at
202058_s_at
202059_s_at
213741_s_at
karyopherin alpha 1 (importin alpha 5) Karyopherin alpha 1 (importin alpha 5) ENSG00000114030 ENSP00000343701 KPNA1 KPNA1 3q21 Approved SRP1, RCH2, NPI-1, IPOA5 KPNA1 karyopherin alpha 1 (importin alpha 5); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...]
3837 KPNB1 3837 HGNC:6400 Hs.532793 208974_x_at
208975_s_at
213507_s_at
213803_at
217027_x_at
karyopherin (importin) beta 1 Karyopherin (importin) beta 1 ENSG00000108424 ENSP00000290158 KPNB1 KPNB1 17q21.32 Approved NTF97, IPOB, MGC2155, MGC2156, MGC2157, IMB1, Impnb, IPO1 KPNB1 karyopherin (importin) beta 1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleopl [...]
4000 LMNA 4000 HGNC:6636 Hs.594444 1554600_s_at
203411_s_at
212086_x_at
212089_at
214213_x_at
lamin A/C Lamin A/C ENSG00000160789 ENSP00000357283 LMNA LMN1, CMD1A, LGMD1B LMNA 1q22 Approved LMNA lamin A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals
4001 LMNB1 4001 HGNC:6637 Hs.89497 203276_at
lamin B1 Lamin B1 ENSG00000113368 ENSP00000261366 LMNB1 LMNB1 5q23.2 Approved LMNB1 lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin
4137 MAPT 4137 HGNC:6893 Hs.101174 203928_x_at
203929_s_at
203930_s_at
206401_s_at
225379_at
microtubule-associated protein tau Microtubule-associated protein tau ENSG00000186868 ENSP00000340820 MAPT DDPAC, MAPTL MAPT 17q21 Approved MTBT1, tau, PPND, FTDP-17, TAU, MSTD, MTBT2, FLJ31424, MGC138549 tau microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabil [...]
4950 OCLN 4950 HGNC:8104 Hs.592605 Occludin ENSG00000197822 ENSP00000347379 OCLN OCLN 5q13.1 Approved OCLN occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions
5062 PAK2 5062 HGNC:8591 Hs.518530 1559052_s_at
205962_at
208875_s_at
208876_s_at
208877_at
208878_s_at
p21 protein (Cdc42/Rac)-activated kinase 2 P21 protein (Cdc42/Rac)-activated kinase 2 ENSG00000180370 ENSP00000314067 PAK2 PAK2 3q29 Approved REACT_6185 PAK65, PAKgamma PAK2 p21 protein (Cdc42/Rac)-activated kinase 2; The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase- activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form
5317 PKP1 5317 HGNC:9023 Hs.497350 205724_at
221854_at
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) ENSG00000081277 ENSP00000263946 PKP1 PKP1 1q32 Approved B6P PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis
5339 PLEC1 5339 HGNC:9069 Hs.434248 201373_at
216971_s_at
plectin 1, intermediate filament binding protein 500kDa Plectin 1, intermediate filament binding protein 500kDa ENSG00000178209 ENSP00000323856 PLEC1 EBS1 PLEC1 8q24 Approved PCN, PLTN PCN plectin 1, intermediate filament binding protein 500kDa; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics
5580 PRKCD 5580 HGNC:9399 Hs.155342 202545_at
protein kinase C, delta Protein kinase C, delta ENSG00000163932 ENSP00000331602 PRKCD PRKCD 3p21.31 Approved PRKCD protein kinase C, delta; This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin
5588 PRKCQ 5588 HGNC:9410 Hs.498570 210038_at
210039_s_at
protein kinase C, theta Protein kinase C, theta ENSG00000065675 ENSP00000263125 PRKCQ PRKCQ 10p15 Approved PRKCQ protein kinase C, theta; This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production
5747 PTK2 5747 HGNC:9611 Hs.395482 1559529_at
207821_s_at
208820_at
241453_at
PTK2 protein tyrosine kinase 2 PTK2 protein tyrosine kinase 2 ENSG00000169398 ENSP00000341189 PTK2 PTK2 8q24.3 Approved FAK, FADK, FAK1 FAK PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity
6093 ROCK1 6093 HGNC:10251 Hs.306307 213044_at
214578_s_at
230239_at
235854_x_at
Rho-associated, coiled-coil containing protein kinase 1 Rho-associated, coiled-coil containing protein kinase 1 ENSG00000067900 ENSP00000382697 ROCK1 ROCK1 18q11.2 Approved p160ROCK ROCK1 Rho-associated, coiled-coil containing protein kinase 1; Phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Required for centromere positioning and centromere-dependent exit from mitosis. Necessary for apoptotic membrane blebbing
6304 SATB1 6304 HGNC:10541 Hs.517717 203408_s_at
241365_at
SATB homeobox 1 SATB homeobox 1 ENSG00000182568 ENSP00000341024 SATB1 SATB1 3p24.3 Approved SATB1 SATB homeobox 1; Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a [...]
6709 SPTAN1 6709 HGNC:11273 Hs.372331 208611_s_at
214925_s_at
214926_at
215235_at
241150_at
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ENSG00000197694 ENSP00000361824 SPTAN1 SPTAN1 9q34.11 Approved SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
8428 STK24 8428 HGNC:11403 Hs.508514 208854_s_at
208855_s_at
215188_at
serine/threonine kinase 24 (STE20 homolog, yeast) Serine/threonine kinase 24 (STE20 homolog, yeast) ENSG00000102572 ENSP00000365730 STK24 STK24 13q31.2-q32.3 Approved MST-3, MST3, MST3B, STK3, STE20 STK24 serine/threonine kinase 24 (STE20 homolog, yeast); Protein kinase that act on both serine and threonine residues
7082 TJP1 7082 HGNC:11827 Hs.510833 202011_at
214168_s_at
tight junction protein 1 (zona occludens 1) Tight junction protein 1 (zona occludens 1) ENSG00000104067 ENSP00000281537 TJP1 TJP1 15q13 Approved ZO-1, MGC133289, DKFZp686M05161 ZO-1 tight junction protein 1 (zona occludens 1); The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions
9414 TJP2 9414 HGNC:11828 Hs.50382 202085_at
232017_at
237132_at
242991_at
tight junction protein 2 (zona occludens 2) Tight junction protein 2 (zona occludens 2) ENSG00000119139 ENSP00000366453 TJP2 TJP2 9q13-q21 Approved ZO-2, X104, ZO2 TJP2 tight junction protein 2 (zona occludens 2); Plays a role in tight junctions and adherens junctions
7431 VIM 7431 HGNC:12692 Hs.642813 1555938_x_at
201426_s_at
vimentin Vimentin ENSG00000026025 ENSP00000224237 VIM VIM 10p13 Approved VIM vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells
51 genes found.

Pathway Download Options. Check boxes below or ALL

ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


OR


Choose Platform:

GPL 571
GPL 8300
GPL 96
GPL 570

Quick Links