NAME: Extrinsic Pathway for Apoptosis

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
811 CALR 811 HGNC:1455 200935_at
212953_x_at
214315_x_at
calreticulin ENSP00000320866 CALR 19p13.3-p13.2 Approved RO, SSA, cC1qR, CRT, FLJ26680 calreticulin; Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1029 CDKN2A 1029 HGNC:1787 Hs.512599 207039_at
209644_x_at
211156_at
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GO:0006309 GO:0006917 GO:0006919 GO:0008637 ENSG00000147889 ENSP00000355153 hsa+1029 CDKN2A CDKN2, MLM CDKN2A IDA IMP 9p21 Approved CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
205394_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
11200 CHEK2 11200 HGNC:16627 Hs.291363 210416_s_at
CHK2 checkpoint homolog (S. pombe) CHK2 checkpoint homolog (S. pombe) GO:0008630 ENSG00000183765 ENSP00000372023 hsa+11200 CHEK2 RAD53 CHEK2 IDA 22q12.1 Approved REACT_1538 CDS1, CHK2, HuCds1, PP1425, bA444G7 CHK2 CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'
3265 HRAS 3265 HGNC:5173 Hs.37003 212983_at
v-Ha-ras Harvey rat sarcoma viral oncogene homolog V-Ha-ras Harvey rat sarcoma viral oncogene homolog ENSG00000174775 ENSP00000309845 HRAS HRAS1 HRAS 11p15.5 Approved REACT_498 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
5604 MAP2K1 5604 HGNC:6840 202670_at
mitogen-activated protein kinase kinase 1 Mitogen-activated protein kinase kinase 1 ENSG00000169032 ENSP00000302486 MAP2K1 PRKMK1 MAP2K1 15q22.1-q22.33 Approved MEK1, MAPKK1 MEK1 mitogen-activated protein kinase kinase 1; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
5580 PRKCD 5580 HGNC:9399 Hs.155342 202545_at
protein kinase C, delta Protein kinase C, delta ENSG00000163932 ENSP00000331602 PRKCD PRKCD 3p21.31 Approved PRKCD protein kinase C, delta; This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin
6722 SRF 6722 HGNC:11291 202400_s_at
202401_s_at
serum response factor (c-fos serum response element-binding transcription factor) ENSG00000112658 ENSP00000265354 SRF 6p Approved MCM1 serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation
7014 TERF2 7014 HGNC:11729 1555183_at
1555185_x_at
203611_at
229790_at
telomeric repeat binding factor 2 ENSG00000132604 ENSP00000254942 TERF2 TRBF2 16q22.1 Approved TRF2 telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed [...]
7015 TERT 7015 HGNC:11730 Hs.492203 telomerase reverse transcriptase Telomerase reverse transcriptase ENSG00000164362 ENSP00000309572 TERT TERT 5p15.33 Approved TRT, TP2, TCS1, hEST2, EST2 telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
51384 WNT16 51384 HGNC:16267 221113_s_at
224022_x_at
wingless-type MMTV integration site family, member 16 ENSG00000002745 ENSP00000222462 WNT16 7q31 Approved wingless-type MMTV integration site family, member 16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)
16 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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