NAME: Granzyme a Mediated Apoptosis Pathway

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
8125 ANP32A 8125 HGNC:13233 Hs.458747 201038_s_at
201043_s_at
201051_at
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A ENSG00000140350 ENSP00000417864 ANP32A C15orf1 ANP32A 15q23 Approved LANP, PP32, I1PP2A, PHAPI, MAPM, mapmodulin LANP acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression
328 APEX1 328 HGNC:587 Hs.73722 210027_s_at
APEX nuclease (multifunctional DNA repair enzyme) 1 APEX nuclease (multifunctional DNA repair enzyme) 1 ENSG00000100823 ENSP00000216714 hsa+328 APEX1 APEX APEX1 14q11.2 Approved APE, REF1, HAP1, APX, APEN, REF-1, APE-1 APX APEX nuclease (multifunctional DNA repair enzyme) 1; Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin
1387 CREBBP 1387 HGNC:2348 Hs.459759 202160_at
211808_s_at
228177_at
235858_at
CREB binding protein CREB binding protein ENSG00000005339 ENSP00000262367 hsa+1387 CREBBP RSTS CREBBP 16p13.3 Approved RTS, CBP, KAT3A CREBBP CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes
1676 DFFA 1676 HGNC:2772 Hs.484782 203277_at
223518_at
226116_at
DNA fragmentation factor, 45kDa, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide GO:0006309 GO:0043066 ENSG00000160049 ENSP00000366237 hsa+1676 DFFA DFFA IDA 1p36.3-p36.2 Approved DFF-45, DFF45, ICAD, DFF1 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40)
1677 DFFB 1677 HGNC:2773 Hs.133089 206752_s_at
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) GO:0006309 GO:0030263 ENSG00000169598 ENSP00000367454 hsa+1677 DFFB DFFB IDA 1p36.3 Approved CAD, CPAN, DFF-40, DFF40 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
3001 GZMA 3001 HGNC:4708 Hs.90708 205488_at
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) GO:0006922 ENSG00000145649 ENSP00000274306 GZMA HFSP, CTLA3 GZMA IDA 5q11-q12 Approved GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. May be involved in apoptosis
3002 GZMB 3002 HGNC:4709 Hs.1051 210164_at
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) GO:0006922 ENSG00000100453 ENSP00000216341 GZMB CTLA1, CSPB GZMB IDA 14q11.2 Approved REACT_578 CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT CSPB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
3148 HMGB2 3148 HGNC:5000 Hs.434953 208808_s_at
236091_at
high-mobility group box 2 High-mobility group box 2 GO:0006288 ENSG00000164104 ENSP00000296503 HMGB2 HMG2 HMGB2 IDA 4q31 Approved HMG2 high-mobility group box 2; Binds preferentially single-stranded DNA and unwinds double stranded DNA
4830 NME1 4830 HGNC:7849 Hs.463456 201577_at
non-metastatic cells 1, protein (NM23A) expressed in Non-metastatic cells 1, protein (NM23A) expressed in ENSG00000011052 ENSP00000013034 NME1 NME1 17q21.33 Approved NM23, NM23-H1 - non-metastatic cells 1, protein (NM23A) expressed in; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Has tumor metastasis-suppressive capacity
5551 PRF1 5551 HGNC:9360 Hs.2200 1553681_a_at
214617_at
perforin 1 (pore forming protein) Perforin 1 (pore forming protein) ENSG00000180644 ENSP00000316746 PRF1 PRF1 10q22 Approved PFP, P1, HPLH2 PRF1 perforin 1 (pore forming protein); In the presence of calcium, binds to target cell membranes. Inserts into target cell membranes and forms pores, and so contributes to cytolysis and apoptosis of target cells
6418 SET 6418 HGNC:10760 Hs.436687 200630_x_at
200631_s_at
210231_x_at
213047_x_at
215780_s_at
40189_at
SET nuclear oncogene SET nuclear oncogene ENSG00000119335 ENSP00000361777 SET SET 9q34 Approved PHAPII, 2PP2A, IPP2A2 SET SET nuclear oncogene; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA- activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of [...]
11 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
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