NAME: NF-kappaB pathway

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
84126 ATRIP 84126 HGNC:33499 1552937_s_at
ATR interacting protein ENSG00000164053 ENSP00000323099 ATRIP 3p24.3-p22.1 Approved FLJ12343, MGC20625, MGC21482, MGC26740 ATR interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
672 BRCA1 672 HGNC:1100 Hs.194143 204531_s_at
211851_x_at
breast cancer 1, early onset Breast cancer 1, early onset GO:0000724 GO:0008630 ENSG00000012048 ENSP00000350283 BRCA1 BRCA1 IDA 17q21-q24 Approved REACT_216 RNF53, BRCC1 RNF53 breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage [...]
595 CCND1 595 HGNC:1582 Hs.523852 208711_s_at
208712_at
cyclin D1 Cyclin D1 ENSG00000110092 ENSP00000227507 hsa+595 CCND1 BCL1, D11S287E, PRAD1 CCND1 11q13 Approved REACT_152 U21B31 BCL1 cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition
894 CCND2 894 HGNC:1583 Hs.376071 200951_s_at
200952_s_at
200953_s_at
cyclin D2 Cyclin D2 ENSG00000118971 ENSP00000261254 hsa+894 CCND2 CCND2 12p13 Approved REACT_152 CCND2 cyclin D2; Essential for the control of the cell cycle at the G1/S (start) transition
898 CCNE1 898 HGNC:1589 Hs.244723 213523_at
242105_at
cyclin E1 Cyclin E1 ENSG00000105173 ENSP00000262643 hsa+898 CCNE1 CCNE CCNE1 19q12 Approved CCNE cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition
9134 CCNE2 9134 HGNC:1590 Hs.567387 205034_at
211814_s_at
cyclin E2 Cyclin E2 ENSG00000175305 ENSP00000309181 hsa+9134 CCNE2 CCNE2 8q22.1 Approved CYCE2 CCNE2 cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
8318 CDC45L 8318 HGNC:1739 Hs.474217 204126_s_at
CDC45 cell division cycle 45-like (S. cerevisiae) CDC45 cell division cycle 45-like (S. cerevisiae) ENSG00000093009 ENSP00000263201 hsa+8318 CDC45L CDC45L2 CDC45L 22q11.21 Approved CDC45L CDC45 cell division cycle 45-like (S. cerevisiae); Required for initiation of chromosomal DNA replication
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1019 CDK4 1019 HGNC:1773 Hs.95577 202246_s_at
cyclin-dependent kinase 4 Cyclin-dependent kinase 4 ENSG00000135446 ENSP00000257904 hsa+1019 CDK4 CDK4 12q13 Approved REACT_152 PSK-J3 CDK4 cyclin-dependent kinase 4; Probably involved in the control of the cell cycle
1021 CDK6 1021 HGNC:1777 Hs.119882 207143_at
224847_at
224848_at
224851_at
231198_at
235287_at
243000_at
cyclin-dependent kinase 6 Cyclin-dependent kinase 6 ENSG00000105810 ENSP00000265734 hsa+1021 CDK6 CDK6 7q21-q22 Approved REACT_152 PLSTIRE CDK6 cyclin-dependent kinase 6; Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1029 CDKN2A 1029 HGNC:1787 Hs.512599 207039_at
209644_x_at
211156_at
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GO:0006309 GO:0006917 GO:0006919 GO:0008637 ENSG00000147889 ENSP00000355153 hsa+1029 CDKN2A CDKN2, MLM CDKN2A IDA IMP 9p21 Approved CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
205394_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
11200 CHEK2 11200 HGNC:16627 Hs.291363 210416_s_at
CHK2 checkpoint homolog (S. pombe) CHK2 checkpoint homolog (S. pombe) GO:0008630 ENSG00000183765 ENSP00000372023 hsa+11200 CHEK2 RAD53 CHEK2 IDA 22q12.1 Approved REACT_1538 CDS1, CHK2, HuCds1, PP1425, bA444G7 CHK2 CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'
63967 CLSPN 63967 HGNC:19715 1553120_at
219621_at
242150_at
243840_at
claspin ENSG00000092853 ENSP00000312995 CLSPN 1p34.3 Approved claspin homolog (Xenopus laevis); Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks
1457 CSNK2A1 1457 HGNC:2457 206075_s_at
212072_s_at
212073_at
212075_s_at
229216_s_at
casein kinase 2, alpha 1 polypeptide ENSG00000101266 CSNK2A1 20p13 Approved
1459 CSNK2A2 1459 HGNC:2459 203575_at
224922_at
casein kinase 2, alpha prime polypeptide ENSG00000070770 CSNK2A2 16 Approved
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
1870 E2F2 1870 HGNC:3114 Hs.194333 207042_at
228361_at
235582_at
E2F transcription factor 2 E2F transcription factor 2 ENSG00000007968 ENSP00000355249 hsa+1870 E2F2 E2F2 1p36 Approved E2F-2 E2F2 E2F transcription factor 2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner
84142 FAM175A 84142 HGNC:25829 226521_s_at
233543_s_at
family with sequence similarity 175, member A ENSG00000163322 FAM175A CCDC98 4q21.23 Approved
3014 H2AFX 3014 HGNC:4739 Hs.477879 205436_s_at
212524_x_at
212525_s_at
213344_s_at
H2A histone family, member X H2A histone family, member X ENSG00000188486 ENSP00000364310 H2AFX H2AX H2AFX 11q23.3 Approved H2AFX H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...]
8334 HIST1H2AC 8334 HGNC:4733 215071_s_at
histone cluster 1, H2ac ENSG00000180573 HIST1H2AC H2AFL 6p22.1 Approved
5606 MAP2K3 5606 HGNC:6843 Hs.514012 207667_s_at
215498_s_at
215499_at
mitogen-activated protein kinase kinase 3 Mitogen-activated protein kinase kinase 3 ENSG00000034152 ENSP00000345083 MAP2K3 PRKMK3 MAP2K3 17q11.2 Approved MEK3, MKK3, MAPKK3 MEK3 mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
5608 MAP2K6 5608 HGNC:6846 205698_s_at
205699_at
mitogen-activated protein kinase kinase 6 MAP2K6 PRKMK6 17q Approved
5600 MAPK11 5600 HGNC:6873 206040_s_at
211499_s_at
211500_at
mitogen-activated protein kinase 11 ENSG00000185386 MAPK11 PRKM11 22q13.33 Approved
6300 MAPK12 6300 HGNC:6874 1556340_at
1556341_s_at
206106_at
mitogen-activated protein kinase 12 ENSG00000188130 MAPK12 SAPK3 22q13.3 Approved
5603 MAPK13 5603 HGNC:6875 210058_at
210059_s_at
mitogen-activated protein kinase 13 ENSG00000156711 MAPK13 PRKM13 6p21 Approved
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
9261 MAPKAPK2 9261 HGNC:6887 201460_at
201461_s_at
215050_x_at
mitogen-activated protein kinase-activated protein kinase 2 ENSG00000162889 MAPKAPK2 1q32 Approved
9656 MDC1 9656 HGNC:21163 203061_s_at
203062_s_at
mediator of DNA-damage checkpoint 1 ENSG00000137337 ENSP00000373060 MDC1 6p21.3 Approved NFBD1, KIAA0170, Em:AB023051.5 mediator of DNA-damage checkpoint 1
4193 MDM2 4193 HGNC:6973 Hs.567303 205385_at
205386_s_at
211832_s_at
217373_x_at
217542_at
225160_x_at
229711_s_at
237891_at
244616_x_at
Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homolog (mouse) ENSG00000135679 ENSP00000417281 hsa+4193 MDM2 MDM2 12q13-q14 Approved HDM2, HDMX HDM2 Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
4361 MRE11A 4361 HGNC:7230 Hs.192649 205395_s_at
211334_at
242456_at
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) MRE11 meiotic recombination 11 homolog A (S. cerevisiae) ENSG00000020922 ENSP00000325863 hsa+4361 MRE11A MRE11 MRE11A 11q21 Approved ATLD MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA li [...]
4683 NBN 4683 HGNC:7652 Hs.492208 202905_x_at
202906_s_at
202907_s_at
217299_s_at
240510_at
nibrin Nibrin ENSG00000104320 ENSP00000265433 hsa+4683 NBN NBS, NBS1 NBN 8q21-q24 Approved ATV, AT-V2, AT-V1 NBN nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...]
5371 PML 5371 HGNC:9113 206503_x_at
209640_at
210362_x_at
211012_s_at
211013_x_at
211014_s_at
211588_s_at
211589_at
235508_at
239582_at
promyelocytic leukemia ENSG00000140464 PML 15q24.1 Approved
25913 POT1 25913 HGNC:17284 204353_s_at
204354_at
protection of telomeres 1 homolog (S. pombe) ENSG00000128513 POT1 7q31.33 Approved
10111 RAD50 10111 HGNC:9816 Hs.655835 208393_s_at
209349_at
RAD50 homolog (S. cerevisiae) RAD50 homolog (S. cerevisiae) ENSG00000113522 ENSP00000265335 hsa+10111 RAD50 RAD50 5q23-q31 Approved hRad50, RAD50-2 RAD50 RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the n [...]
5925 RB1 5925 HGNC:9884 Hs.408528 203132_at
211540_s_at
retinoblastoma 1 Retinoblastoma 1 ENSG00000139687 ENSP00000267163 hsa+5925 RB1 OSRC RB1 13q14.2 Approved REACT_152 REACT_383 RB1 retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repres [...]
165918 RNF168 165918 HGNC:26661 1553127_a_at
226832_at
ring finger protein 168 ENSG00000163961 RNF168 3q29 Approved
9025 RNF8 9025 HGNC:10071 203160_s_at
203161_s_at
ring finger protein 8 ENSG00000112130 RNF8 6p21.3 Approved
6117 RPA1 6117 HGNC:10289 Hs.461925 201528_at
201529_s_at
236675_at
replication protein A1, 70kDa Replication protein A1, 70kDa GO:0000718 GO:0006297 ENSG00000132383 ENSP00000254719 hsa+6117 RPA1 RPA1 EXP 17p13.3 Approved REPA1, RPA70, HSSB, RF-A, RP-A MST075 replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing
6118 RPA2 6118 HGNC:10290 Hs.79411 201756_at
replication protein A2, 32kDa Replication protein A2, 32kDa GO:0000718 GO:0006297 ENSG00000117748 ENSP00000363021 hsa+6118 RPA2 RPA2 EXP 1p35 Approved RPA2 replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
6119 RPA3 6119 HGNC:10291 Hs.487540 209507_at
replication protein A3, 14kDa Replication protein A3, 14kDa GO:0000718 GO:0006297 ENSG00000106399 ENSP00000223129 hsa+6119 RPA3 RPA3 EXP 7 Approved REPA3 RPA3 replication protein A3, 14kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
29935 RPA4 29935 HGNC:30305 Hs.659349 221143_at
replication protein A4, 34kDa Replication protein A4, 34kDa ENSG00000204086 ENSP00000362131 hsa+29935 RPA4 RPA4 Xq21 Approved HSU24186 RPA4 replication protein A4, 34kDa; Absolutely required for simian virus 40 DNA replication in vitro. It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein (By similarity)
57551 TAOK1 57551 HGNC:29259 216310_at
227454_at
TAO kinase 1 ENSP00000261716 TAOK1 17q11.2 Approved KIAA1361, MARKK, PSK2, MAP3K16, FLJ14314, TAO1 TAO kinase 1; Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the specific activation of the upstream MKK3 kinase
9344 TAOK2 9344 HGNC:16835 204877_s_at
204878_s_at
204986_s_at
TAO kinase 2 ENSG00000149930 TAOK2 16p11.2 Approved
51347 TAOK3 51347 HGNC:18133 220761_s_at
221508_at
TAO kinase 3 TAOK3 12q Approved
7014 TERF2 7014 HGNC:11729 1555183_at
1555185_x_at
203611_at
229790_at
telomeric repeat binding factor 2 ENSG00000132604 ENSP00000254942 TERF2 TRBF2 16q22.1 Approved TRF2 telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed [...]
54386 TERF2IP 54386 HGNC:19246 201174_s_at
telomeric repeat binding factor 2, interacting protein ENSG00000166848 TERF2IP 16q23.1 Approved
11073 TOPBP1 11073 HGNC:17008 202633_at
topoisomerase (DNA) II binding protein 1 ENSG00000163781 TOPBP1 3q22.1 Approved
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
7158 TP53BP1 7158 HGNC:11999 Hs.440968 1569097_at
1569098_s_at
203050_at
tumor protein p53 binding protein 1 Tumor protein p53 binding protein 1 ENSG00000067369 ENSP00000371475 TP53BP1 TP53BP1 15q15-q21 Approved 53BP1, p202 TP53BP1 tumor protein p53 binding protein 1; May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage
51720 UIMC1 51720 HGNC:30298 220746_s_at
ubiquitin interaction motif containing 1 ENSG00000087206 UIMC1 5q35.2 Approved
56 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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